* using log directory 'd:/Rcompile/CRANpkg/local/3.6/tableone.Rcheck' * using R version 3.6.3 (2020-02-29) * using platform: x86_64-w64-mingw32 (64-bit) * using session charset: ISO8859-1 * checking for file 'tableone/DESCRIPTION' ... OK * checking extension type ... Package * this is package 'tableone' version '0.12.0' * checking package namespace information ... OK * checking package dependencies ... OK * checking if this is a source package ... OK * checking if there is a namespace ... OK * checking for hidden files and directories ... OK * checking for portable file names ... OK * checking whether package 'tableone' can be installed ... OK * checking installed package size ... OK * checking package directory ... OK * checking 'build' directory ... OK * checking DESCRIPTION meta-information ... OK * checking top-level files ... OK * checking for left-over files ... OK * checking index information ... OK * checking package subdirectories ... OK * checking R files for non-ASCII characters ... OK * checking R files for syntax errors ... OK * checking whether the package can be loaded ... OK * checking whether the package can be loaded with stated dependencies ... OK * checking whether the package can be unloaded cleanly ... OK * checking whether the namespace can be loaded with stated dependencies ... OK * checking whether the namespace can be unloaded cleanly ... OK * checking loading without being on the library search path ... OK * checking use of S3 registration ... OK * checking dependencies in R code ... OK * checking S3 generic/method consistency ... OK * checking replacement functions ... OK * checking foreign function calls ... OK * checking R code for possible problems ... [13s] OK * checking Rd files ... OK * checking Rd metadata ... OK * checking Rd cross-references ... OK * checking for missing documentation entries ... OK * checking for code/documentation mismatches ... OK * checking Rd \usage sections ... OK * checking Rd contents ... OK * checking for unstated dependencies in examples ... OK * checking installed files from 'inst/doc' ... OK * checking files in 'vignettes' ... OK * checking examples ... [14s] OK * checking for unstated dependencies in 'tests' ... OK * checking tests ... [140s] ERROR Running 'test-all.R' [140s] Running the tests in 'tests/test-all.R' failed. Complete output: > ################################################################################ > ### Unit tests for the package > ## Reference: http://adv-r.had.co.nz/Testing.html > ## See the testthat subdirectory for actual test code > ## Created on: 2014-06-01 > ## Author: Kazuki Yoshida > ################################################################################ > > > ### Run all tests > ################################################################################ > library(testthat) > test_check("tableone") Loading required package: tableone Overall Missing n 418 time (mean (SD)) 1917.78 (1104.67) 0.0 status (%) 0.0 0 232 (55.5) 1 25 ( 6.0) 2 161 (38.5) age (mean (SD)) 50.74 (10.45) 0.0 sex = f (%) 374 (89.5) 0.0 ascites = 1 (%) 24 ( 7.7) 25.4 hepato = 1 (%) 160 (51.3) 25.4 spiders = 1 (%) 90 (28.8) 25.4 edema (%) 0.0 0 354 (84.7) 0.5 44 (10.5) 1 20 ( 4.8) bili (mean (SD)) 3.22 (4.41) 0.0 chol (mean (SD)) 369.51 (231.94) 32.1 albumin (mean (SD)) 3.50 (0.42) 0.0 copper (mean (SD)) 97.65 (85.61) 25.8 alk.phos (mean (SD)) 1982.66 (2140.39) 25.4 ast (mean (SD)) 122.56 (56.70) 25.4 trig (mean (SD)) 124.70 (65.15) 32.5 platelet (mean (SD)) 257.02 (98.33) 2.6 protime (mean (SD)) 10.73 (1.02) 0.5 stage (%) 1.4 1 21 ( 5.1) 2 92 (22.3) 3 155 (37.6) 4 144 (35.0) Overall Missing n 418 time (mean (SD)) 1917.78 (1104.67) 0.0 status (%) 0.0 0 232 (55.5) 1 25 ( 6.0) 2 161 (38.5) age (mean (SD)) 50.74 (10.45) 0.0 sex = f (%) 374 (89.5) 0.0 ascites (%) 25.4 0 288 (68.9) 1 24 ( 5.7) NA 106 (25.4) hepato (%) 25.4 0 152 (36.4) 1 160 (38.3) NA 106 (25.4) spiders (%) 25.4 0 222 (53.1) 1 90 (21.5) NA 106 (25.4) edema (%) 0.0 0 354 (84.7) 0.5 44 (10.5) 1 20 ( 4.8) bili (mean (SD)) 3.22 (4.41) 0.0 chol (mean (SD)) 369.51 (231.94) 32.1 albumin (mean (SD)) 3.50 (0.42) 0.0 copper (mean (SD)) 97.65 (85.61) 25.8 alk.phos (mean (SD)) 1982.66 (2140.39) 25.4 ast (mean (SD)) 122.56 (56.70) 25.4 trig (mean (SD)) 124.70 (65.15) 32.5 platelet (mean (SD)) 257.02 (98.33) 2.6 protime (mean (SD)) 10.73 (1.02) 0.5 stage (%) 1.4 1 21 ( 5.0) 2 92 (22.0) 3 155 (37.1) 4 144 (34.4) NA 6 ( 1.4) Stratified by trt 1 2 p test Missing n 158 154 time (mean (SD)) 2015.62 (1094.12) 1996.86 (1155.93) 0.883 0.0 status (%) 0.894 0.0 0 83 (52.5) 85 (55.2) 1 10 ( 6.3) 9 ( 5.8) 2 65 (41.1) 60 (39.0) age (mean (SD)) 51.42 (11.01) 48.58 (9.96) 0.018 0.0 sex = f (%) 137 (86.7) 139 (90.3) 0.421 0.0 ascites = 1 (%) 14 ( 8.9) 10 ( 6.5) 0.567 25.4 hepato = 1 (%) 73 (46.2) 87 (56.5) 0.088 25.4 spiders = 1 (%) 45 (28.5) 45 (29.2) 0.985 25.4 edema (%) 0.877 0.0 0 132 (83.5) 131 (85.1) 0.5 16 (10.1) 13 ( 8.4) 1 10 ( 6.3) 10 ( 6.5) bili (mean (SD)) 2.87 (3.63) 3.65 (5.28) 0.131 0.0 chol (mean (SD)) 365.01 (209.54) 373.88 (252.48) 0.748 32.1 albumin (mean (SD)) 3.52 (0.44) 3.52 (0.40) 0.874 0.0 copper (mean (SD)) 97.64 (90.59) 97.65 (80.49) 0.999 25.8 alk.phos (mean (SD)) 2021.30 (2183.44) 1943.01 (2101.69) 0.747 25.4 ast (mean (SD)) 120.21 (54.52) 124.97 (58.93) 0.460 25.4 trig (mean (SD)) 124.14 (71.54) 125.25 (58.52) 0.886 32.5 platelet (mean (SD)) 258.75 (100.32) 265.20 (90.73) 0.555 2.6 protime (mean (SD)) 10.65 (0.85) 10.80 (1.14) 0.197 0.5 stage (%) 0.201 1.4 1 12 ( 7.6) 4 ( 2.6) 2 35 (22.2) 32 (20.8) 3 56 (35.4) 64 (41.6) 4 55 (34.8) 54 (35.1) Stratified by trt:sex 1:m 2:m 1:f n 21 15 137 time (mean (SD)) 1793.48 (1244.70) 2156.33 (1428.56) 2049.67 (1070.20) status (%) 0 4 (19.0) 7 (46.7) 79 ( 57.7) 1 3 (14.3) 0 ( 0.0) 7 ( 5.1) 2 14 (66.7) 8 (53.3) 51 ( 37.2) age (mean (SD)) 55.57 (12.61) 57.09 (10.07) 50.78 (10.65) sex = f (%) 0 ( 0.0) 0 ( 0.0) 137 (100.0) ascites = 1 (%) 1 ( 4.8) 2 (13.3) 13 ( 9.5) hepato = 1 (%) 12 (57.1) 9 (60.0) 61 ( 44.5) spiders = 1 (%) 3 (14.3) 1 ( 6.7) 42 ( 30.7) edema (%) 0 17 (81.0) 12 (80.0) 115 ( 83.9) 0.5 3 (14.3) 1 ( 6.7) 13 ( 9.5) 1 1 ( 4.8) 2 (13.3) 9 ( 6.6) bili (mean (SD)) 2.98 (2.11) 2.72 (2.46) 2.86 (3.81) chol (mean (SD)) 403.43 (204.95) 301.00 (111.32) 358.24 (210.46) albumin (mean (SD)) 3.63 (0.43) 3.50 (0.49) 3.50 (0.44) copper (mean (SD)) 174.90 (105.33) 125.40 (89.18) 85.71 (82.27) alk.phos (mean (SD)) 2486.16 (2385.32) 1734.45 (2478.07) 1950.04 (2151.35) ast (mean (SD)) 128.71 (48.74) 112.58 (44.38) 118.91 (55.40) trig (mean (SD)) 145.81 (56.62) 114.86 (39.59) 120.28 (73.41) platelet (mean (SD)) 232.65 (97.38) 240.13 (73.93) 262.59 (100.53) protime (mean (SD)) 10.84 (0.94) 11.23 (0.97) 10.62 (0.84) stage (%) 1 2 ( 9.5) 1 ( 6.7) 10 ( 7.3) 2 4 (19.0) 2 (13.3) 31 ( 22.6) 3 7 (33.3) 5 (33.3) 49 ( 35.8) 4 8 (38.1) 7 (46.7) 47 ( 34.3) Stratified by trt:sex 2:f p test Missing n 139 time (mean (SD)) 1979.65 (1127.52) 0.730 0.0 status (%) 0.033 0.0 0 78 ( 56.1) 1 9 ( 6.5) 2 52 ( 37.4) age (mean (SD)) 47.66 (9.54) <0.001 0.0 sex = f (%) 139 (100.0) <0.001 0.0 ascites = 1 (%) 8 ( 5.8) 0.516 25.4 hepato = 1 (%) 78 ( 56.1) 0.208 25.4 spiders = 1 (%) 44 ( 31.7) 0.089 25.4 edema (%) 0.906 0.0 0 119 ( 85.6) 0.5 12 ( 8.6) 1 8 ( 5.8) bili (mean (SD)) 3.75 (5.50) 0.394 0.0 chol (mean (SD)) 381.73 (262.26) 0.512 32.1 albumin (mean (SD)) 3.53 (0.39) 0.585 0.0 copper (mean (SD)) 94.64 (79.25) <0.001 25.8 alk.phos (mean (SD)) 1965.52 (2066.15) 0.706 25.4 ast (mean (SD)) 126.30 (60.27) 0.598 25.4 trig (mean (SD)) 126.38 (60.22) 0.370 32.5 platelet (mean (SD)) 267.95 (92.20) 0.362 2.6 protime (mean (SD)) 10.75 (1.15) 0.137 0.5 stage (%) 0.646 1.4 1 3 ( 2.2) 2 30 ( 21.6) 3 59 ( 42.4) 4 47 ( 33.8) Stratified by trt Overall 1 2 n 418 158 154 time (mean (SD)) 1917.78 (1104.67) 2015.62 (1094.12) 1996.86 (1155.93) status (%) 0 232 (55.5) 83 (52.5) 85 (55.2) 1 25 ( 6.0) 10 ( 6.3) 9 ( 5.8) 2 161 (38.5) 65 (41.1) 60 (39.0) age (mean (SD)) 50.74 (10.45) 51.42 (11.01) 48.58 (9.96) sex = f (%) 374 (89.5) 137 (86.7) 139 (90.3) ascites = 1 (%) 24 ( 7.7) 14 ( 8.9) 10 ( 6.5) hepato = 1 (%) 160 (51.3) 73 (46.2) 87 (56.5) spiders = 1 (%) 90 (28.8) 45 (28.5) 45 (29.2) edema (%) 0 354 (84.7) 132 (83.5) 131 (85.1) 0.5 44 (10.5) 16 (10.1) 13 ( 8.4) 1 20 ( 4.8) 10 ( 6.3) 10 ( 6.5) bili (mean (SD)) 3.22 (4.41) 2.87 (3.63) 3.65 (5.28) chol (mean (SD)) 369.51 (231.94) 365.01 (209.54) 373.88 (252.48) albumin (mean (SD)) 3.50 (0.42) 3.52 (0.44) 3.52 (0.40) copper (mean (SD)) 97.65 (85.61) 97.64 (90.59) 97.65 (80.49) alk.phos (mean (SD)) 1982.66 (2140.39) 2021.30 (2183.44) 1943.01 (2101.69) ast (mean (SD)) 122.56 (56.70) 120.21 (54.52) 124.97 (58.93) trig (mean (SD)) 124.70 (65.15) 124.14 (71.54) 125.25 (58.52) platelet (mean (SD)) 257.02 (98.33) 258.75 (100.32) 265.20 (90.73) protime (mean (SD)) 10.73 (1.02) 10.65 (0.85) 10.80 (1.14) stage (%) 1 21 ( 5.1) 12 ( 7.6) 4 ( 2.6) 2 92 (22.3) 35 (22.2) 32 (20.8) 3 155 (37.6) 56 (35.4) 64 (41.6) 4 144 (35.0) 55 (34.8) 54 (35.1) Stratified by trt p test Missing n time (mean (SD)) 0.883 0.0 status (%) 0.894 0.0 0 1 2 age (mean (SD)) 0.018 0.0 sex = f (%) 0.421 0.0 ascites = 1 (%) 0.567 25.4 hepato = 1 (%) 0.088 25.4 spiders = 1 (%) 0.985 25.4 edema (%) 0.877 0.0 0 0.5 1 bili (mean (SD)) 0.131 0.0 chol (mean (SD)) 0.748 32.1 albumin (mean (SD)) 0.874 0.0 copper (mean (SD)) 0.999 25.8 alk.phos (mean (SD)) 0.747 25.4 ast (mean (SD)) 0.460 25.4 trig (mean (SD)) 0.886 32.5 platelet (mean (SD)) 0.555 2.6 protime (mean (SD)) 0.197 0.5 stage (%) 0.201 1.4 1 2 3 4 Stratified by trt:sex Overall 1:m 2:m n 418 21 15 time (mean (SD)) 1917.78 (1104.67) 1793.48 (1244.70) 2156.33 (1428.56) status (%) 0 232 (55.5) 4 (19.0) 7 (46.7) 1 25 ( 6.0) 3 (14.3) 0 ( 0.0) 2 161 (38.5) 14 (66.7) 8 (53.3) age (mean (SD)) 50.74 (10.45) 55.57 (12.61) 57.09 (10.07) sex = f (%) 374 (89.5) 0 ( 0.0) 0 ( 0.0) ascites = 1 (%) 24 ( 7.7) 1 ( 4.8) 2 (13.3) hepato = 1 (%) 160 (51.3) 12 (57.1) 9 (60.0) spiders = 1 (%) 90 (28.8) 3 (14.3) 1 ( 6.7) edema (%) 0 354 (84.7) 17 (81.0) 12 (80.0) 0.5 44 (10.5) 3 (14.3) 1 ( 6.7) 1 20 ( 4.8) 1 ( 4.8) 2 (13.3) bili (mean (SD)) 3.22 (4.41) 2.98 (2.11) 2.72 (2.46) chol (mean (SD)) 369.51 (231.94) 403.43 (204.95) 301.00 (111.32) albumin (mean (SD)) 3.50 (0.42) 3.63 (0.43) 3.50 (0.49) copper (mean (SD)) 97.65 (85.61) 174.90 (105.33) 125.40 (89.18) alk.phos (mean (SD)) 1982.66 (2140.39) 2486.16 (2385.32) 1734.45 (2478.07) ast (mean (SD)) 122.56 (56.70) 128.71 (48.74) 112.58 (44.38) trig (mean (SD)) 124.70 (65.15) 145.81 (56.62) 114.86 (39.59) platelet (mean (SD)) 257.02 (98.33) 232.65 (97.38) 240.13 (73.93) protime (mean (SD)) 10.73 (1.02) 10.84 (0.94) 11.23 (0.97) stage (%) 1 21 ( 5.1) 2 ( 9.5) 1 ( 6.7) 2 92 (22.3) 4 (19.0) 2 (13.3) 3 155 (37.6) 7 (33.3) 5 (33.3) 4 144 (35.0) 8 (38.1) 7 (46.7) Stratified by trt:sex 1:f 2:f p test Missing n 137 139 time (mean (SD)) 2049.67 (1070.20) 1979.65 (1127.52) 0.730 0.0 status (%) 0.033 0.0 0 79 ( 57.7) 78 ( 56.1) 1 7 ( 5.1) 9 ( 6.5) 2 51 ( 37.2) 52 ( 37.4) age (mean (SD)) 50.78 (10.65) 47.66 (9.54) <0.001 0.0 sex = f (%) 137 (100.0) 139 (100.0) <0.001 0.0 ascites = 1 (%) 13 ( 9.5) 8 ( 5.8) 0.516 25.4 hepato = 1 (%) 61 ( 44.5) 78 ( 56.1) 0.208 25.4 spiders = 1 (%) 42 ( 30.7) 44 ( 31.7) 0.089 25.4 edema (%) 0.906 0.0 0 115 ( 83.9) 119 ( 85.6) 0.5 13 ( 9.5) 12 ( 8.6) 1 9 ( 6.6) 8 ( 5.8) bili (mean (SD)) 2.86 (3.81) 3.75 (5.50) 0.394 0.0 chol (mean (SD)) 358.24 (210.46) 381.73 (262.26) 0.512 32.1 albumin (mean (SD)) 3.50 (0.44) 3.53 (0.39) 0.585 0.0 copper (mean (SD)) 85.71 (82.27) 94.64 (79.25) <0.001 25.8 alk.phos (mean (SD)) 1950.04 (2151.35) 1965.52 (2066.15) 0.706 25.4 ast (mean (SD)) 118.91 (55.40) 126.30 (60.27) 0.598 25.4 trig (mean (SD)) 120.28 (73.41) 126.38 (60.22) 0.370 32.5 platelet (mean (SD)) 262.59 (100.53) 267.95 (92.20) 0.362 2.6 protime (mean (SD)) 10.62 (0.84) 10.75 (1.15) 0.137 0.5 stage (%) 0.646 1.4 1 10 ( 7.3) 3 ( 2.2) 2 31 ( 22.6) 30 ( 21.6) 3 49 ( 35.8) 59 ( 42.4) 4 47 ( 34.3) 47 ( 33.8) Stratified by trt 1 2 n 158 154 time (mean (SD)) 2015.62 (1094.12) 1996.86 (1155.93) status (%) 0 83 (52.5) 85 ( 55.2) 1 10 ( 6.3) 9 ( 5.8) 2 65 (41.1) 60 ( 39.0) trt = 2 (%) 0 ( 0.0) 154 (100.0) age (mean (SD)) 51.42 (11.01) 48.58 (9.96) sex = f (%) 137 (86.7) 139 ( 90.3) ascites = 1 (%) 14 ( 8.9) 10 ( 6.5) hepato = 1 (%) 73 (46.2) 87 ( 56.5) spiders = 1 (%) 45 (28.5) 45 ( 29.2) edema (%) 0 132 (83.5) 131 ( 85.1) 0.5 16 (10.1) 13 ( 8.4) 1 10 ( 6.3) 10 ( 6.5) bili (median [IQR]) 1.40 [0.80, 3.20] 1.30 [0.72, 3.60] chol (median [IQR]) 315.50 [247.75, 417.00] 303.50 [254.25, 377.00] albumin (mean (SD)) 3.52 (0.44) 3.52 (0.40) copper (median [IQR]) 73.00 [40.00, 121.00] 73.00 [43.00, 139.00] alk.phos (median [IQR]) 1214.50 [840.75, 2028.00] 1283.00 [922.50, 1949.75] ast (mean (SD)) 120.21 (54.52) 124.97 (58.93) trig (median [IQR]) 106.00 [84.50, 146.00] 113.00 [84.50, 155.00] platelet (mean (SD)) 258.75 (100.32) 265.20 (90.73) protime (mean (SD)) 10.65 (0.85) 10.80 (1.14) stage (%) 1 12 ( 7.6) 4 ( 2.6) 2 35 (22.2) 32 ( 20.8) 3 56 (35.4) 64 ( 41.6) 4 55 (34.8) 54 ( 35.1) Stratified by trt SMD Missing n time (mean (SD)) 0.017 0.0 status (%) 0.054 0.0 0 1 2 trt = 2 (%) NaN 25.4 age (mean (SD)) 0.270 0.0 sex = f (%) 0.111 0.0 ascites = 1 (%) 0.089 25.4 hepato = 1 (%) 0.207 25.4 spiders = 1 (%) 0.016 25.4 edema (%) 0.058 0.0 0 0.5 1 bili (median [IQR]) 0.171 0.0 chol (median [IQR]) 0.038 32.1 albumin (mean (SD)) 0.018 0.0 copper (median [IQR]) <0.001 25.8 alk.phos (median [IQR]) 0.037 25.4 ast (mean (SD)) 0.084 25.4 trig (median [IQR]) 0.017 32.5 platelet (mean (SD)) 0.067 2.6 protime (mean (SD)) 0.146 0.5 stage (%) 0.246 1.4 1 2 3 4 Stratified by trt 1 2 n 158 154 time (mean (SD)) 2015.62 (1094.12) 1996.86 (1155.93) status (%) 0 83 (52.5) 85 ( 55.2) 1 10 ( 6.3) 9 ( 5.8) 2 65 (41.1) 60 ( 39.0) trt = 2 (%) 0 ( 0.0) 154 (100.0) age (mean (SD)) 51.42 (11.01) 48.58 (9.96) sex = f (%) 137 (86.7) 139 ( 90.3) ascites = 1 (%) 14 ( 8.9) 10 ( 6.5) hepato = 1 (%) 73 (46.2) 87 ( 56.5) spiders = 1 (%) 45 (28.5) 45 ( 29.2) edema (%) 0 132 (83.5) 131 ( 85.1) 0.5 16 (10.1) 13 ( 8.4) 1 10 ( 6.3) 10 ( 6.5) bili (median [IQR]) 1.40 [0.80, 3.20] 1.30 [0.72, 3.60] chol (median [IQR]) 315.50 [247.75, 417.00] 303.50 [254.25, 377.00] albumin (mean (SD)) 3.52 (0.44) 3.52 (0.40) copper (median [IQR]) 73.00 [40.00, 121.00] 73.00 [43.00, 139.00] alk.phos (median [IQR]) 1214.50 [840.75, 2028.00] 1283.00 [922.50, 1949.75] ast (mean (SD)) 120.21 (54.52) 124.97 (58.93) trig (median [IQR]) 106.00 [84.50, 146.00] 113.00 [84.50, 155.00] platelet (mean (SD)) 258.75 (100.32) 265.20 (90.73) protime (mean (SD)) 10.65 (0.85) 10.80 (1.14) stage (%) 1 12 ( 7.6) 4 ( 2.6) 2 35 (22.2) 32 ( 20.8) 3 56 (35.4) 64 ( 41.6) 4 55 (34.8) 54 ( 35.1) Stratified by trt SMD Missing n time (mean (SD)) 0.017 0.0 status (%) 0.054 0.0 0 1 2 trt = 2 (%) NaN 25.4 age (mean (SD)) 0.270 0.0 sex = f (%) 0.111 0.0 ascites = 1 (%) 0.089 25.4 hepato = 1 (%) 0.207 25.4 spiders = 1 (%) 0.016 25.4 edema (%) 0.058 0.0 0 0.5 1 bili (median [IQR]) 0.171 0.0 chol (median [IQR]) 0.038 32.1 albumin (mean (SD)) 0.018 0.0 copper (median [IQR]) <0.001 25.8 alk.phos (median [IQR]) 0.037 25.4 ast (mean (SD)) 0.084 25.4 trig (median [IQR]) 0.017 32.5 platelet (mean (SD)) 0.067 2.6 protime (mean (SD)) 0.146 0.5 stage (%) 0.246 1.4 1 2 3 4 Overall n 418 time (mean (SD)) 1917.78 (1104.67) status (%) 0 232 (55.5) 1 25 ( 6.0) 2 161 (38.5) age (mean (SD)) 50.74 (10.45) sex = f (%) 374 (89.5) ascites = 1 (%) 24 ( 7.7) hepato = 1 (%) 160 (51.3) spiders = 1 (%) 90 (28.8) edema (%) 0 354 (84.7) 0.5 44 (10.5) 1 20 ( 4.8) bili (mean (SD)) 3.22 (4.41) chol (mean (SD)) 369.51 (231.94) albumin (mean (SD)) 3.50 (0.42) copper (mean (SD)) 97.65 (85.61) alk.phos (mean (SD)) 1982.66 (2140.39) ast (mean (SD)) 122.56 (56.70) trig (mean (SD)) 124.70 (65.15) platelet (mean (SD)) 257.02 (98.33) protime (mean (SD)) 10.73 (1.02) stage (%) 1 21 ( 5.1) 2 92 (22.3) 3 155 (37.6) 4 144 (35.0) Overall n 418 time (mean (SD)) 1917.78 (1104.67) status (%) 0 232 (55.5) 1 25 ( 6.0) 2 161 (38.5) age (mean (SD)) 50.74 (10.45) sex (%) 374 (89.5) ascites (%) 24 ( 7.7) hepato (%) 160 (51.3) spiders (%) 90 (28.8) edema (%) 0 354 (84.7) 0.5 44 (10.5) 1 20 ( 4.8) bili (mean (SD)) 3.22 (4.41) chol (mean (SD)) 369.51 (231.94) albumin (mean (SD)) 3.50 (0.42) copper (mean (SD)) 97.65 (85.61) alk.phos (mean (SD)) 1982.66 (2140.39) ast (mean (SD)) 122.56 (56.70) trig (mean (SD)) 124.70 (65.15) platelet (mean (SD)) 257.02 (98.33) protime (mean (SD)) 10.73 (1.02) stage (%) 1 21 ( 5.1) 2 92 (22.3) 3 155 (37.6) 4 144 (35.0) Overall n 418 time (mean (SD)) 1917.78 (1104.67) status (%) 0 232 (55.5) 1 25 ( 6.0) 2 161 (38.5) age (mean (SD)) 50.74 (10.45) sex = f (%) 374 (89.5) ascites = 1 (%) 24 ( 7.7) hepato = 1 (%) 160 (51.3) spiders = 1 (%) 90 (28.8) edema (%) 0 354 (84.7) 0.5 44 (10.5) 1 20 ( 4.8) bili (mean (SD)) 3.22 (4.41) chol (mean (SD)) 369.51 (231.94) albumin (mean (SD)) 3.50 (0.42) copper (mean (SD)) 97.65 (85.61) alk.phos (mean (SD)) 1982.66 (2140.39) ast (mean (SD)) 122.56 (56.70) trig (mean (SD)) 124.70 (65.15) platelet (mean (SD)) 257.02 (98.33) protime (mean (SD)) 10.73 (1.02) stage (%) 1 21 ( 5.1) 2 92 (22.3) 3 155 (37.6) 4 144 (35.0) Overall n 418 time (mean (SD)) 1917.78 (1104.67) status (%) 0 232 (55.5) 1 25 ( 6.0) 2 161 (38.5) Age in Years (mean (SD)) 50.74 (10.45) Female Sex = f (%) 374 (89.5) ascites = 1 (%) 24 ( 7.7) hepato = 1 (%) 160 (51.3) spiders = 1 (%) 90 (28.8) edema (%) 0 354 (84.7) 0.5 44 (10.5) 1 20 ( 4.8) bili (mean (SD)) 3.22 (4.41) chol (mean (SD)) 369.51 (231.94) albumin (mean (SD)) 3.50 (0.42) copper (mean (SD)) 97.65 (85.61) alk.phos (mean (SD)) 1982.66 (2140.39) ast (mean (SD)) 122.56 (56.70) trig (mean (SD)) 124.70 (65.15) platelet (mean (SD)) 257.02 (98.33) protime (mean (SD)) 10.73 (1.02) Stage of the Disease (%) 1 21 ( 5.1) 2 92 (22.3) 3 155 (37.6) 4 144 (35.0) Stratified by trt 1 2 p test n 158 154 time (mean (SD)) 2015.62 (1094.12) 1996.86 (1155.93) 0.883 status (%) 0.894 0 83 (52.5) 85 (55.2) 1 10 ( 6.3) 9 ( 5.8) 2 65 (41.1) 60 (39.0) age (mean (SD)) 51.42 (11.01) 48.58 (9.96) 0.018 sex = f (%) 137 (86.7) 139 (90.3) 0.421 ascites = 1 (%) 14 ( 8.9) 10 ( 6.5) 0.567 hepato = 1 (%) 73 (46.2) 87 (56.5) 0.088 spiders = 1 (%) 45 (28.5) 45 (29.2) 0.985 edema (%) 0.877 0 132 (83.5) 131 (85.1) 0.5 16 (10.1) 13 ( 8.4) 1 10 ( 6.3) 10 ( 6.5) bili (mean (SD)) 2.87 (3.63) 3.65 (5.28) 0.131 chol (mean (SD)) 365.01 (209.54) 373.88 (252.48) 0.748 albumin (mean (SD)) 3.52 (0.44) 3.52 (0.40) 0.874 copper (mean (SD)) 97.64 (90.59) 97.65 (80.49) 0.999 alk.phos (mean (SD)) 2021.30 (2183.44) 1943.01 (2101.69) 0.747 ast (mean (SD)) 120.21 (54.52) 124.97 (58.93) 0.460 trig (mean (SD)) 124.14 (71.54) 125.25 (58.52) 0.886 platelet (mean (SD)) 258.75 (100.32) 265.20 (90.73) 0.555 protime (mean (SD)) 10.65 (0.85) 10.80 (1.14) 0.197 stage (%) 0.201 1 12 ( 7.6) 4 ( 2.6) 2 35 (22.2) 32 (20.8) 3 56 (35.4) 64 (41.6) 4 55 (34.8) 54 (35.1) Stratified by trt 1 2 p test n 158 154 time (mean (SD)) 2015.62 (1094.12) 1996.86 (1155.93) 0.883 status (%) 0.894 0 83 (52.5) 85 (55.2) 1 10 ( 6.3) 9 ( 5.8) 2 65 (41.1) 60 (39.0) age (mean (SD)) 51.42 (11.01) 48.58 (9.96) 0.018 sex = f (%) 137 (86.7) 139 (90.3) 0.421 ascites = 1 (%) 14 ( 8.9) 10 ( 6.5) 0.567 hepato = 1 (%) 73 (46.2) 87 (56.5) 0.088 spiders = 1 (%) 45 (28.5) 45 (29.2) 0.985 edema (%) 0.877 0 132 (83.5) 131 (85.1) 0.5 16 (10.1) 13 ( 8.4) 1 10 ( 6.3) 10 ( 6.5) bili (mean (SD)) 2.87 (3.63) 3.65 (5.28) 0.131 chol (mean (SD)) 365.01 (209.54) 373.88 (252.48) 0.748 albumin (mean (SD)) 3.52 (0.44) 3.52 (0.40) 0.874 copper (mean (SD)) 97.64 (90.59) 97.65 (80.49) 0.999 alk.phos (mean (SD)) 2021.30 (2183.44) 1943.01 (2101.69) 0.747 ast (mean (SD)) 120.21 (54.52) 124.97 (58.93) 0.460 trig (mean (SD)) 124.14 (71.54) 125.25 (58.52) 0.886 platelet (mean (SD)) 258.75 (100.32) 265.20 (90.73) 0.555 protime (mean (SD)) 10.65 (0.85) 10.80 (1.14) 0.197 stage (%) 0.201 1 12 ( 7.6) 4 ( 2.6) 2 35 (22.2) 32 (20.8) 3 56 (35.4) 64 (41.6) 4 55 (34.8) 54 (35.1) Overall n 418 time (mean (SD)) 1917.78 (1104.67) status (%) 0 232 (55.5) 1 25 ( 6.0) 2 161 (38.5) age (mean (SD)) 50.74 (10.45) sex = f (%) 374 (89.5) ascites = 1 (%) 24 ( 7.7) hepato = 1 (%) 160 (51.3) spiders = 1 (%) 90 (28.8) edema (%) 0 354 (84.7) 0.5 44 (10.5) 1 20 ( 4.8) bili (mean (SD)) 3.22 (4.41) chol (mean (SD)) 369.51 (231.94) albumin (mean (SD)) 3.50 (0.42) copper (mean (SD)) 97.65 (85.61) alk.phos (mean (SD)) 1982.66 (2140.39) ast (mean (SD)) 122.56 (56.70) trig (mean (SD)) 124.70 (65.15) platelet (mean (SD)) 257.02 (98.33) protime (mean (SD)) 10.73 (1.02) stage (%) 1 21 ( 5.1) 2 92 (22.3) 3 155 (37.6) 4 144 (35.0) Overall n 418 time (mean (SD)) 1917.78 (1104.67) status (%) 0 232 (55.5) 1 25 ( 6.0) 2 161 (38.5) age (mean (SD)) 50.74 (10.45) sex = f (%) 374 (89.5) ascites = 1 (%) 24 ( 7.7) hepato = 1 (%) 160 (51.3) spiders = 1 (%) 90 (28.8) edema (%) 0 354 (84.7) 0.5 44 (10.5) 1 20 ( 4.8) bili (mean (SD)) 3.22 (4.41) chol (mean (SD)) 369.51 (231.94) albumin (mean (SD)) 3.50 (0.42) copper (mean (SD)) 97.65 (85.61) alk.phos (mean (SD)) 1982.66 (2140.39) ast (mean (SD)) 122.56 (56.70) trig (mean (SD)) 124.70 (65.15) platelet (mean (SD)) 257.02 (98.33) protime (mean (SD)) 10.73 (1.02) stage (%) 1 21 ( 5.1) 2 92 (22.3) 3 155 (37.6) 4 144 (35.0) Overall n 418 time (mean (SD)) 1917.78 (1104.67) status (%) 0 232 (55.5) 1 25 ( 6.0) 2 161 (38.5) age (mean (SD)) 50.74 (10.45) sex = f (%) 374 (89.5) ascites (%) 0 288 (68.9) 1 24 ( 5.7) NA 106 (25.4) hepato (%) 0 152 (36.4) 1 160 (38.3) NA 106 (25.4) spiders (%) 0 222 (53.1) 1 90 (21.5) NA 106 (25.4) edema (%) 0 354 (84.7) 0.5 44 (10.5) 1 20 ( 4.8) bili (mean (SD)) 3.22 (4.41) chol (mean (SD)) 369.51 (231.94) albumin (mean (SD)) 3.50 (0.42) copper (mean (SD)) 97.65 (85.61) alk.phos (mean (SD)) 1982.66 (2140.39) ast (mean (SD)) 122.56 (56.70) trig (mean (SD)) 124.70 (65.15) platelet (mean (SD)) 257.02 (98.33) protime (mean (SD)) 10.73 (1.02) stage (%) 1 21 ( 5.0) 2 92 (22.0) 3 155 (37.1) 4 144 (34.4) NA 6 ( 1.4) Overall n 418 time (mean (SD)) 1917.78 (1104.67) status (%) 0 232 (55.5) 1 25 ( 6.0) 2 161 (38.5) age (mean (SD)) 50.74 (10.45) sex = f (%) 374 (89.5) ascites (%) 0 288 (68.9) 1 24 ( 5.7) NA 106 (25.4) hepato (%) 0 152 (36.4) 1 160 (38.3) NA 106 (25.4) spiders (%) 0 222 (53.1) 1 90 (21.5) NA 106 (25.4) edema (%) 0 354 (84.7) 0.5 44 (10.5) 1 20 ( 4.8) bili (mean (SD)) 3.22 (4.41) chol (mean (SD)) 369.51 (231.94) albumin (mean (SD)) 3.50 (0.42) copper (mean (SD)) 97.65 (85.61) alk.phos (mean (SD)) 1982.66 (2140.39) ast (mean (SD)) 122.56 (56.70) trig (mean (SD)) 124.70 (65.15) platelet (mean (SD)) 257.02 (98.33) protime (mean (SD)) 10.73 (1.02) stage (%) 1 21 ( 5.0) 2 92 (22.0) 3 155 (37.1) 4 144 (34.4) NA 6 ( 1.4) Stratified by trt:sex 1:m 2:m 1:f n 21 15 137 time (mean (SD)) 1793.48 (1244.70) 2156.33 (1428.56) 2049.67 (1070.20) status (%) 0 4 (19.0) 7 (46.7) 79 ( 57.7) 1 3 (14.3) 0 ( 0.0) 7 ( 5.1) 2 14 (66.7) 8 (53.3) 51 ( 37.2) age (mean (SD)) 55.57 (12.61) 57.09 (10.07) 50.78 (10.65) sex = f (%) 0 ( 0.0) 0 ( 0.0) 137 (100.0) ascites = 1 (%) 1 ( 4.8) 2 (13.3) 13 ( 9.5) hepato = 1 (%) 12 (57.1) 9 (60.0) 61 ( 44.5) spiders = 1 (%) 3 (14.3) 1 ( 6.7) 42 ( 30.7) edema (%) 0 17 (81.0) 12 (80.0) 115 ( 83.9) 0.5 3 (14.3) 1 ( 6.7) 13 ( 9.5) 1 1 ( 4.8) 2 (13.3) 9 ( 6.6) bili (mean (SD)) 2.98 (2.11) 2.72 (2.46) 2.86 (3.81) chol (mean (SD)) 403.43 (204.95) 301.00 (111.32) 358.24 (210.46) albumin (mean (SD)) 3.63 (0.43) 3.50 (0.49) 3.50 (0.44) copper (mean (SD)) 174.90 (105.33) 125.40 (89.18) 85.71 (82.27) alk.phos (mean (SD)) 2486.16 (2385.32) 1734.45 (2478.07) 1950.04 (2151.35) ast (mean (SD)) 128.71 (48.74) 112.58 (44.38) 118.91 (55.40) trig (mean (SD)) 145.81 (56.62) 114.86 (39.59) 120.28 (73.41) platelet (mean (SD)) 232.65 (97.38) 240.13 (73.93) 262.59 (100.53) protime (mean (SD)) 10.84 (0.94) 11.23 (0.97) 10.62 (0.84) stage (%) 1 2 ( 9.5) 1 ( 6.7) 10 ( 7.3) 2 4 (19.0) 2 (13.3) 31 ( 22.6) 3 7 (33.3) 5 (33.3) 49 ( 35.8) 4 8 (38.1) 7 (46.7) 47 ( 34.3) Stratified by trt:sex 2:f p test n 139 time (mean (SD)) 1979.65 (1127.52) 0.730 status (%) 0.033 0 78 ( 56.1) 1 9 ( 6.5) 2 52 ( 37.4) age (mean (SD)) 47.66 (9.54) <0.001 sex = f (%) 139 (100.0) <0.001 ascites = 1 (%) 8 ( 5.8) 0.516 hepato = 1 (%) 78 ( 56.1) 0.208 spiders = 1 (%) 44 ( 31.7) 0.089 edema (%) 0.906 0 119 ( 85.6) 0.5 12 ( 8.6) 1 8 ( 5.8) bili (mean (SD)) 3.75 (5.50) 0.394 chol (mean (SD)) 381.73 (262.26) 0.512 albumin (mean (SD)) 3.53 (0.39) 0.585 copper (mean (SD)) 94.64 (79.25) <0.001 alk.phos (mean (SD)) 1965.52 (2066.15) 0.706 ast (mean (SD)) 126.30 (60.27) 0.598 trig (mean (SD)) 126.38 (60.22) 0.370 platelet (mean (SD)) 267.95 (92.20) 0.362 protime (mean (SD)) 10.75 (1.15) 0.137 stage (%) 0.646 1 3 ( 2.2) 2 30 ( 21.6) 3 59 ( 42.4) 4 47 ( 33.8) Stratified by trt:sex 1:m 2:m 1:f n 21 15 137 time (mean (SD)) 1793.48 (1244.70) 2156.33 (1428.56) 2049.67 (1070.20) status (%) 0 4 (19.0) 7 (46.7) 79 ( 57.7) 1 3 (14.3) 0 ( 0.0) 7 ( 5.1) 2 14 (66.7) 8 (53.3) 51 ( 37.2) age (mean (SD)) 55.57 (12.61) 57.09 (10.07) 50.78 (10.65) sex = f (%) 0 ( 0.0) 0 ( 0.0) 137 (100.0) ascites = 1 (%) 1 ( 4.8) 2 (13.3) 13 ( 9.5) hepato = 1 (%) 12 (57.1) 9 (60.0) 61 ( 44.5) spiders = 1 (%) 3 (14.3) 1 ( 6.7) 42 ( 30.7) edema (%) 0 17 (81.0) 12 (80.0) 115 ( 83.9) 0.5 3 (14.3) 1 ( 6.7) 13 ( 9.5) 1 1 ( 4.8) 2 (13.3) 9 ( 6.6) bili (mean (SD)) 2.98 (2.11) 2.72 (2.46) 2.86 (3.81) chol (mean (SD)) 403.43 (204.95) 301.00 (111.32) 358.24 (210.46) albumin (mean (SD)) 3.63 (0.43) 3.50 (0.49) 3.50 (0.44) copper (mean (SD)) 174.90 (105.33) 125.40 (89.18) 85.71 (82.27) alk.phos (mean (SD)) 2486.16 (2385.32) 1734.45 (2478.07) 1950.04 (2151.35) ast (mean (SD)) 128.71 (48.74) 112.58 (44.38) 118.91 (55.40) trig (mean (SD)) 145.81 (56.62) 114.86 (39.59) 120.28 (73.41) platelet (mean (SD)) 232.65 (97.38) 240.13 (73.93) 262.59 (100.53) protime (mean (SD)) 10.84 (0.94) 11.23 (0.97) 10.62 (0.84) stage (%) 1 2 ( 9.5) 1 ( 6.7) 10 ( 7.3) 2 4 (19.0) 2 (13.3) 31 ( 22.6) 3 7 (33.3) 5 (33.3) 49 ( 35.8) 4 8 (38.1) 7 (46.7) 47 ( 34.3) Stratified by trt:sex 2:f p test n 139 time (mean (SD)) 1979.65 (1127.52) 0.730 status (%) 0.033 0 78 ( 56.1) 1 9 ( 6.5) 2 52 ( 37.4) age (mean (SD)) 47.66 (9.54) <0.001 sex = f (%) 139 (100.0) <0.001 ascites = 1 (%) 8 ( 5.8) 0.516 hepato = 1 (%) 78 ( 56.1) 0.208 spiders = 1 (%) 44 ( 31.7) 0.089 edema (%) 0.906 0 119 ( 85.6) 0.5 12 ( 8.6) 1 8 ( 5.8) bili (mean (SD)) 3.75 (5.50) 0.394 chol (mean (SD)) 381.73 (262.26) 0.512 albumin (mean (SD)) 3.53 (0.39) 0.585 copper (mean (SD)) 94.64 (79.25) <0.001 alk.phos (mean (SD)) 1965.52 (2066.15) 0.706 ast (mean (SD)) 126.30 (60.27) 0.598 trig (mean (SD)) 126.38 (60.22) 0.370 platelet (mean (SD)) 267.95 (92.20) 0.362 protime (mean (SD)) 10.75 (1.15) 0.137 stage (%) 0.646 1 3 ( 2.2) 2 30 ( 21.6) 3 59 ( 42.4) 4 47 ( 33.8) Stratified by trt 1 2 p n 158 154 time (mean (SD)) 2015.6203 (1094.1233) 1996.8636 (1155.9289) 0.88305 status (%) 0.89351 0 83 (52.532) 85 (55.195) 1 10 ( 6.329) 9 ( 5.844) 2 65 (41.139) 60 (38.961) age (mean (SD)) 51.4191 (11.0072) 48.5825 (9.9578) 0.01767 sex = f (%) 137 (86.709) 139 (90.260) 0.42123 ascites = 1 (%) 14 ( 8.861) 10 ( 6.494) 0.56729 hepato = 1 (%) 73 (46.203) 87 (56.494) 0.08821 spiders = 1 (%) 45 (28.481) 45 (29.221) 0.98466 edema (%) 0.87682 0 132 (83.544) 131 (85.065) 0.5 16 (10.127) 13 ( 8.442) 1 10 ( 6.329) 10 ( 6.494) bili (mean (SD)) 2.8734 (3.6289) 3.6487 (5.2819) 0.13094 chol (mean (SD)) 365.0143 (209.5439) 373.8819 (252.4846) 0.74799 albumin (mean (SD)) 3.5163 (0.4433) 3.5238 (0.3958) 0.87388 copper (mean (SD)) 97.6433 (90.5901) 97.6536 (80.4865) 0.99916 alk.phos (mean (SD)) 2021.2975 (2183.4358) 1943.0104 (2101.6873) 0.74726 ast (mean (SD)) 120.2087 (54.5214) 124.9650 (58.9313) 0.45970 trig (mean (SD)) 124.1367 (71.5391) 125.2517 (58.5211) 0.88604 platelet (mean (SD)) 258.7500 (100.3247) 265.2039 (90.7294) 0.55451 protime (mean (SD)) 10.6532 (0.8514) 10.8000 (1.1382) 0.19714 stage (%) 0.20130 1 12 ( 7.595) 4 ( 2.597) 2 35 (22.152) 32 (20.779) 3 56 (35.443) 64 (41.558) 4 55 (34.810) 54 (35.065) Stratified by trt test n time (mean (SD)) status (%) 0 1 2 age (mean (SD)) sex = f (%) ascites = 1 (%) hepato = 1 (%) spiders = 1 (%) edema (%) 0 0.5 1 bili (mean (SD)) chol (mean (SD)) albumin (mean (SD)) copper (mean (SD)) alk.phos (mean (SD)) ast (mean (SD)) trig (mean (SD)) platelet (mean (SD)) protime (mean (SD)) stage (%) 1 2 3 4 Stratified by trt 1 2 p n 158 154 time (mean (SD)) 2015.6203 (1094.1233) 1996.8636 (1155.9289) 0.88305 status (%) 0.89351 0 83 (52.532) 85 (55.195) 1 10 ( 6.329) 9 ( 5.844) 2 65 (41.139) 60 (38.961) age (mean (SD)) 51.4191 (11.0072) 48.5825 (9.9578) 0.01767 sex = f (%) 137 (86.709) 139 (90.260) 0.42123 ascites = 1 (%) 14 ( 8.861) 10 ( 6.494) 0.56729 hepato = 1 (%) 73 (46.203) 87 (56.494) 0.08821 spiders = 1 (%) 45 (28.481) 45 (29.221) 0.98466 edema (%) 0.87682 0 132 (83.544) 131 (85.065) 0.5 16 (10.127) 13 ( 8.442) 1 10 ( 6.329) 10 ( 6.494) bili (mean (SD)) 2.8734 (3.6289) 3.6487 (5.2819) 0.13094 chol (mean (SD)) 365.0143 (209.5439) 373.8819 (252.4846) 0.74799 albumin (mean (SD)) 3.5163 (0.4433) 3.5238 (0.3958) 0.87388 copper (mean (SD)) 97.6433 (90.5901) 97.6536 (80.4865) 0.99916 alk.phos (mean (SD)) 2021.2975 (2183.4358) 1943.0104 (2101.6873) 0.74726 ast (mean (SD)) 120.2087 (54.5214) 124.9650 (58.9313) 0.45970 trig (mean (SD)) 124.1367 (71.5391) 125.2517 (58.5211) 0.88604 platelet (mean (SD)) 258.7500 (100.3247) 265.2039 (90.7294) 0.55451 protime (mean (SD)) 10.6532 (0.8514) 10.8000 (1.1382) 0.19714 stage (%) 0.20130 1 12 ( 7.595) 4 ( 2.597) 2 35 (22.152) 32 (20.779) 3 56 (35.443) 64 (41.558) 4 55 (34.810) 54 (35.065) Stratified by trt test n time (mean (SD)) status (%) 0 1 2 age (mean (SD)) sex = f (%) ascites = 1 (%) hepato = 1 (%) spiders = 1 (%) edema (%) 0 0.5 1 bili (mean (SD)) chol (mean (SD)) albumin (mean (SD)) copper (mean (SD)) alk.phos (mean (SD)) ast (mean (SD)) trig (mean (SD)) platelet (mean (SD)) protime (mean (SD)) stage (%) 1 2 3 4 Stratified by trt 1 2 n 158 154 time (mean (SD)) 2015.62 (1094.12) 1996.86 (1155.93) status (%) 0 83 (52.5) 85 (55.2) 1 10 ( 6.3) 9 ( 5.8) 2 65 (41.1) 60 (39.0) age (mean (SD)) 51.42 (11.01) 48.58 (9.96) sex = f (%) 137 (86.7) 139 (90.3) ascites = 1 (%) 14 ( 8.9) 10 ( 6.5) hepato = 1 (%) 73 (46.2) 87 (56.5) spiders = 1 (%) 45 (28.5) 45 (29.2) edema (%) 0 132 (83.5) 131 (85.1) 0.5 16 (10.1) 13 ( 8.4) 1 10 ( 6.3) 10 ( 6.5) bili (mean (SD)) 2.87 (3.63) 3.65 (5.28) chol (mean (SD)) 365.01 (209.54) 373.88 (252.48) albumin (mean (SD)) 3.52 (0.44) 3.52 (0.40) copper (mean (SD)) 97.64 (90.59) 97.65 (80.49) alk.phos (mean (SD)) 2021.30 (2183.44) 1943.01 (2101.69) ast (mean (SD)) 120.21 (54.52) 124.97 (58.93) trig (mean (SD)) 124.14 (71.54) 125.25 (58.52) platelet (mean (SD)) 258.75 (100.32) 265.20 (90.73) protime (mean (SD)) 10.65 (0.85) 10.80 (1.14) stage (%) 1 12 ( 7.6) 4 ( 2.6) 2 35 (22.2) 32 (20.8) 3 56 (35.4) 64 (41.6) 4 55 (34.8) 54 (35.1) Stratified by trt 1 2 n 158 154 time (mean (SD)) 2015.62 (1094.12) 1996.86 (1155.93) status (%) 0 83 (52.5) 85 (55.2) 1 10 ( 6.3) 9 ( 5.8) 2 65 (41.1) 60 (39.0) age (mean (SD)) 51.42 (11.01) 48.58 (9.96) sex = f (%) 137 (86.7) 139 (90.3) ascites = 1 (%) 14 ( 8.9) 10 ( 6.5) hepato = 1 (%) 73 (46.2) 87 (56.5) spiders = 1 (%) 45 (28.5) 45 (29.2) edema (%) 0 132 (83.5) 131 (85.1) 0.5 16 (10.1) 13 ( 8.4) 1 10 ( 6.3) 10 ( 6.5) bili (mean (SD)) 2.87 (3.63) 3.65 (5.28) chol (mean (SD)) 365.01 (209.54) 373.88 (252.48) albumin (mean (SD)) 3.52 (0.44) 3.52 (0.40) copper (mean (SD)) 97.64 (90.59) 97.65 (80.49) alk.phos (mean (SD)) 2021.30 (2183.44) 1943.01 (2101.69) ast (mean (SD)) 120.21 (54.52) 124.97 (58.93) trig (mean (SD)) 124.14 (71.54) 125.25 (58.52) platelet (mean (SD)) 258.75 (100.32) 265.20 (90.73) protime (mean (SD)) 10.65 (0.85) 10.80 (1.14) stage (%) 1 12 ( 7.6) 4 ( 2.6) 2 35 (22.2) 32 (20.8) 3 56 (35.4) 64 (41.6) 4 55 (34.8) 54 (35.1) Stratified by trt 1 2 n 158 154 time (mean (SD)) 2015.62 (1094.12) 1996.86 (1155.93) status (%) 0 83 (52.5) 85 (55.2) 1 10 ( 6.3) 9 ( 5.8) 2 65 (41.1) 60 (39.0) age (mean (SD)) 51.42 (11.01) 48.58 (9.96) sex = f (%) 137 (86.7) 139 (90.3) ascites = 1 (%) 14 ( 8.9) 10 ( 6.5) hepato = 1 (%) 73 (46.2) 87 (56.5) spiders = 1 (%) 45 (28.5) 45 (29.2) edema (%) 0 132 (83.5) 131 (85.1) 0.5 16 (10.1) 13 ( 8.4) 1 10 ( 6.3) 10 ( 6.5) bili (median [IQR]) 1.40 [0.80, 3.20] 1.30 [0.72, 3.60] chol (median [IQR]) 315.50 [247.75, 417.00] 303.50 [254.25, 377.00] albumin (mean (SD)) 3.52 (0.44) 3.52 (0.40) copper (median [IQR]) 73.00 [40.00, 121.00] 73.00 [43.00, 139.00] alk.phos (median [IQR]) 1214.50 [840.75, 2028.00] 1283.00 [922.50, 1949.75] ast (mean (SD)) 120.21 (54.52) 124.97 (58.93) trig (median [IQR]) 106.00 [84.50, 146.00] 113.00 [84.50, 155.00] platelet (mean (SD)) 258.75 (100.32) 265.20 (90.73) protime (mean (SD)) 10.65 (0.85) 10.80 (1.14) stage (%) 1 12 ( 7.6) 4 ( 2.6) 2 35 (22.2) 32 (20.8) 3 56 (35.4) 64 (41.6) 4 55 (34.8) 54 (35.1) Stratified by trt p test n time (mean (SD)) 0.883 status (%) 0.884 exact 0 1 2 age (mean (SD)) 0.018 sex = f (%) 0.421 ascites = 1 (%) 0.567 hepato = 1 (%) 0.088 spiders = 1 (%) 0.985 edema (%) 0.877 0 0.5 1 bili (median [IQR]) 0.842 nonnorm chol (median [IQR]) 0.544 nonnorm albumin (mean (SD)) 0.874 copper (median [IQR]) 0.717 nonnorm alk.phos (median [IQR]) 0.812 nonnorm ast (mean (SD)) 0.460 trig (median [IQR]) 0.370 nonnorm platelet (mean (SD)) 0.555 protime (mean (SD)) 0.197 stage (%) 0.205 exact 1 2 3 4 Stratified by trt 1 2 n 158 154 time (mean (SD)) 2015.62 (1094.12) 1996.86 (1155.93) status (%) 0 83 (52.5) 85 (55.2) 1 10 ( 6.3) 9 ( 5.8) 2 65 (41.1) 60 (39.0) age (mean (SD)) 51.42 (11.01) 48.58 (9.96) sex = f (%) 137 (86.7) 139 (90.3) ascites = 1 (%) 14 ( 8.9) 10 ( 6.5) hepato = 1 (%) 73 (46.2) 87 (56.5) spiders = 1 (%) 45 (28.5) 45 (29.2) edema (%) 0 132 (83.5) 131 (85.1) 0.5 16 (10.1) 13 ( 8.4) 1 10 ( 6.3) 10 ( 6.5) bili (median [IQR]) 1.40 [0.80, 3.20] 1.30 [0.72, 3.60] chol (median [IQR]) 315.50 [247.75, 417.00] 303.50 [254.25, 377.00] albumin (mean (SD)) 3.52 (0.44) 3.52 (0.40) copper (median [IQR]) 73.00 [40.00, 121.00] 73.00 [43.00, 139.00] alk.phos (median [IQR]) 1214.50 [840.75, 2028.00] 1283.00 [922.50, 1949.75] ast (mean (SD)) 120.21 (54.52) 124.97 (58.93) trig (median [IQR]) 106.00 [84.50, 146.00] 113.00 [84.50, 155.00] platelet (mean (SD)) 258.75 (100.32) 265.20 (90.73) protime (mean (SD)) 10.65 (0.85) 10.80 (1.14) stage (%) 1 12 ( 7.6) 4 ( 2.6) 2 35 (22.2) 32 (20.8) 3 56 (35.4) 64 (41.6) 4 55 (34.8) 54 (35.1) Stratified by trt p test n time (mean (SD)) 0.883 status (%) 0.884 exact 0 1 2 age (mean (SD)) 0.018 sex = f (%) 0.421 ascites = 1 (%) 0.567 hepato = 1 (%) 0.088 spiders = 1 (%) 0.985 edema (%) 0.877 0 0.5 1 bili (median [IQR]) 0.842 nonnorm chol (median [IQR]) 0.544 nonnorm albumin (mean (SD)) 0.874 copper (median [IQR]) 0.717 nonnorm alk.phos (median [IQR]) 0.812 nonnorm ast (mean (SD)) 0.460 trig (median [IQR]) 0.370 nonnorm platelet (mean (SD)) 0.555 protime (mean (SD)) 0.197 stage (%) 0.205 exact 1 2 3 4 Stratified by trt 1 n 158 time (mean (SD)) 2015.62 (1094.12) status (%) 0 83 (52.5) 1 10 ( 6.3) 2 65 (41.1) age (mean (SD)) 51.42 (11.01) sex = f (%) 137 (86.7) ascites = 1 (%) 14 ( 8.9) hepato = 1 (%) 73 (46.2) spiders = 1 (%) 45 (28.5) edema (%) 0 132 (83.5) 0.5 16 (10.1) 1 10 ( 6.3) bili (median [range]) 1.40 [0.30, 20.00] chol (median [range]) 315.50 [127.00, 1712.00] albumin (mean (SD)) 3.52 (0.44) copper (median [range]) 73.00 [9.00, 588.00] alk.phos (median [range]) 1214.50 [369.00, 11552.00] ast (mean (SD)) 120.21 (54.52) trig (median [range]) 106.00 [33.00, 598.00] platelet (mean (SD)) 258.75 (100.32) protime (mean (SD)) 10.65 (0.85) stage (%) 1 12 ( 7.6) 2 35 (22.2) 3 56 (35.4) 4 55 (34.8) Stratified by trt 2 p test n 154 time (mean (SD)) 1996.86 (1155.93) 0.883 status (%) 0.894 0 85 (55.2) 1 9 ( 5.8) 2 60 (39.0) age (mean (SD)) 48.58 (9.96) 0.018 sex = f (%) 139 (90.3) 0.421 ascites = 1 (%) 10 ( 6.5) 0.567 hepato = 1 (%) 87 (56.5) 0.088 spiders = 1 (%) 45 (29.2) 0.985 edema (%) 0.877 0 131 (85.1) 0.5 13 ( 8.4) 1 10 ( 6.5) bili (median [range]) 1.30 [0.30, 28.00] 0.842 nonnorm chol (median [range]) 303.50 [120.00, 1775.00] 0.544 nonnorm albumin (mean (SD)) 3.52 (0.40) 0.874 copper (median [range]) 73.00 [4.00, 558.00] 0.717 nonnorm alk.phos (median [range]) 1283.00 [289.00, 13862.40] 0.812 nonnorm ast (mean (SD)) 124.97 (58.93) 0.460 trig (median [range]) 113.00 [44.00, 432.00] 0.370 nonnorm platelet (mean (SD)) 265.20 (90.73) 0.555 protime (mean (SD)) 10.80 (1.14) 0.197 stage (%) 0.201 1 4 ( 2.6) 2 32 (20.8) 3 64 (41.6) 4 54 (35.1) Stratified by trt 1 n 158 time (mean (SD)) 2015.62 (1094.12) status (%) 0 83 (52.5) 1 10 ( 6.3) 2 65 (41.1) age (mean (SD)) 51.42 (11.01) sex = f (%) 137 (86.7) ascites = 1 (%) 14 ( 8.9) hepato = 1 (%) 73 (46.2) spiders = 1 (%) 45 (28.5) edema (%) 0 132 (83.5) 0.5 16 (10.1) 1 10 ( 6.3) bili (median [range]) 1.40 [0.30, 20.00] chol (median [range]) 315.50 [127.00, 1712.00] albumin (mean (SD)) 3.52 (0.44) copper (median [range]) 73.00 [9.00, 588.00] alk.phos (median [range]) 1214.50 [369.00, 11552.00] ast (mean (SD)) 120.21 (54.52) trig (median [range]) 106.00 [33.00, 598.00] platelet (mean (SD)) 258.75 (100.32) protime (mean (SD)) 10.65 (0.85) stage (%) 1 12 ( 7.6) 2 35 (22.2) 3 56 (35.4) 4 55 (34.8) Stratified by trt 2 p test n 154 time (mean (SD)) 1996.86 (1155.93) 0.883 status (%) 0.894 0 85 (55.2) 1 9 ( 5.8) 2 60 (39.0) age (mean (SD)) 48.58 (9.96) 0.018 sex = f (%) 139 (90.3) 0.421 ascites = 1 (%) 10 ( 6.5) 0.567 hepato = 1 (%) 87 (56.5) 0.088 spiders = 1 (%) 45 (29.2) 0.985 edema (%) 0.877 0 131 (85.1) 0.5 13 ( 8.4) 1 10 ( 6.5) bili (median [range]) 1.30 [0.30, 28.00] 0.842 nonnorm chol (median [range]) 303.50 [120.00, 1775.00] 0.544 nonnorm albumin (mean (SD)) 3.52 (0.40) 0.874 copper (median [range]) 73.00 [4.00, 558.00] 0.717 nonnorm alk.phos (median [range]) 1283.00 [289.00, 13862.40] 0.812 nonnorm ast (mean (SD)) 124.97 (58.93) 0.460 trig (median [range]) 113.00 [44.00, 432.00] 0.370 nonnorm platelet (mean (SD)) 265.20 (90.73) 0.555 protime (mean (SD)) 10.80 (1.14) 0.197 stage (%) 0.201 1 4 ( 2.6) 2 32 (20.8) 3 64 (41.6) 4 54 (35.1) Stratified by trt 1 2 n 158 154 time (mean (SD)) 2015.62 (1094.12) 1996.86 (1155.93) status (%) 0 83 (52.5) 85 (55.2) 1 10 (6.3) 9 (5.8) 2 65 (41.1) 60 (39.0) age (mean (SD)) 51.42 (11.01) 48.58 (9.96) sex = f (%) 137 (86.7) 139 (90.3) ascites = 1 (%) 14 (8.9) 10 (6.5) hepato = 1 (%) 73 (46.2) 87 (56.5) spiders = 1 (%) 45 (28.5) 45 (29.2) edema (%) 0 132 (83.5) 131 (85.1) 0.5 16 (10.1) 13 (8.4) 1 10 (6.3) 10 (6.5) bili (median [IQR]) 1.40 [0.80, 3.20] 1.30 [0.72, 3.60] chol (median [IQR]) 315.50 [247.75, 417.00] 303.50 [254.25, 377.00] albumin (mean (SD)) 3.52 (0.44) 3.52 (0.40) copper (median [IQR]) 73.00 [40.00, 121.00] 73.00 [43.00, 139.00] alk.phos (median [IQR]) 1214.50 [840.75, 2028.00] 1283.00 [922.50, 1949.75] ast (mean (SD)) 120.21 (54.52) 124.97 (58.93) trig (median [IQR]) 106.00 [84.50, 146.00] 113.00 [84.50, 155.00] platelet (mean (SD)) 258.75 (100.32) 265.20 (90.73) protime (mean (SD)) 10.65 (0.85) 10.80 (1.14) stage (%) 1 12 (7.6) 4 (2.6) 2 35 (22.2) 32 (20.8) 3 56 (35.4) 64 (41.6) 4 55 (34.8) 54 (35.1) Stratified by trt p test n time (mean (SD)) 0.883 status (%) 0.884 exact 0 1 2 age (mean (SD)) 0.018 sex = f (%) 0.421 ascites = 1 (%) 0.567 hepato = 1 (%) 0.088 spiders = 1 (%) 0.985 edema (%) 0.877 0 0.5 1 bili (median [IQR]) 0.842 nonnorm chol (median [IQR]) 0.544 nonnorm albumin (mean (SD)) 0.874 copper (median [IQR]) 0.717 nonnorm alk.phos (median [IQR]) 0.812 nonnorm ast (mean (SD)) 0.460 trig (median [IQR]) 0.370 nonnorm platelet (mean (SD)) 0.555 protime (mean (SD)) 0.197 stage (%) 0.205 exact 1 2 3 4 Stratified by trt 1 2 n 158 154 time (mean (SD)) 2015.62 (1094.12) 1996.86 (1155.93) status (%) 0 83 (52.5) 85 (55.2) 1 10 (6.3) 9 (5.8) 2 65 (41.1) 60 (39.0) age (mean (SD)) 51.42 (11.01) 48.58 (9.96) sex = f (%) 137 (86.7) 139 (90.3) ascites = 1 (%) 14 (8.9) 10 (6.5) hepato = 1 (%) 73 (46.2) 87 (56.5) spiders = 1 (%) 45 (28.5) 45 (29.2) edema (%) 0 132 (83.5) 131 (85.1) 0.5 16 (10.1) 13 (8.4) 1 10 (6.3) 10 (6.5) bili (median [IQR]) 1.40 [0.80, 3.20] 1.30 [0.72, 3.60] chol (median [IQR]) 315.50 [247.75, 417.00] 303.50 [254.25, 377.00] albumin (mean (SD)) 3.52 (0.44) 3.52 (0.40) copper (median [IQR]) 73.00 [40.00, 121.00] 73.00 [43.00, 139.00] alk.phos (median [IQR]) 1214.50 [840.75, 2028.00] 1283.00 [922.50, 1949.75] ast (mean (SD)) 120.21 (54.52) 124.97 (58.93) trig (median [IQR]) 106.00 [84.50, 146.00] 113.00 [84.50, 155.00] platelet (mean (SD)) 258.75 (100.32) 265.20 (90.73) protime (mean (SD)) 10.65 (0.85) 10.80 (1.14) stage (%) 1 12 (7.6) 4 (2.6) 2 35 (22.2) 32 (20.8) 3 56 (35.4) 64 (41.6) 4 55 (34.8) 54 (35.1) Stratified by trt p test n time (mean (SD)) 0.883 status (%) 0.884 exact 0 1 2 age (mean (SD)) 0.018 sex = f (%) 0.421 ascites = 1 (%) 0.567 hepato = 1 (%) 0.088 spiders = 1 (%) 0.985 edema (%) 0.877 0 0.5 1 bili (median [IQR]) 0.842 nonnorm chol (median [IQR]) 0.544 nonnorm albumin (mean (SD)) 0.874 copper (median [IQR]) 0.717 nonnorm alk.phos (median [IQR]) 0.812 nonnorm ast (mean (SD)) 0.460 trig (median [IQR]) 0.370 nonnorm platelet (mean (SD)) 0.555 protime (mean (SD)) 0.197 stage (%) 0.205 exact 1 2 3 4 Stratified by trt level 1 n 158 time (mean (SD)) 2015.62 (1094.12) status (%) 0 83 (52.5) 1 10 ( 6.3) 2 65 (41.1) age (mean (SD)) 51.42 (11.01) sex (%) m 21 (13.3) f 137 (86.7) ascites (%) 0 144 (91.1) 1 14 ( 8.9) hepato (%) 0 85 (53.8) 1 73 (46.2) spiders (%) 0 113 (71.5) 1 45 (28.5) edema (%) 0 132 (83.5) 0.5 16 (10.1) 1 10 ( 6.3) bili (median [IQR]) 1.40 [0.80, 3.20] chol (median [IQR]) 315.50 [247.75, 417.00] albumin (mean (SD)) 3.52 (0.44) copper (median [IQR]) 73.00 [40.00, 121.00] alk.phos (median [IQR]) 1214.50 [840.75, 2028.00] ast (mean (SD)) 120.21 (54.52) trig (median [IQR]) 106.00 [84.50, 146.00] platelet (mean (SD)) 258.75 (100.32) protime (mean (SD)) 10.65 (0.85) stage (%) 1 12 ( 7.6) 2 35 (22.2) 3 56 (35.4) 4 55 (34.8) Stratified by trt 2 p test n 154 time (mean (SD)) 1996.86 (1155.93) 0.883 status (%) 85 (55.2) 0.884 exact 9 ( 5.8) 60 (39.0) age (mean (SD)) 48.58 (9.96) 0.018 sex (%) 15 ( 9.7) 0.421 139 (90.3) ascites (%) 144 (93.5) 0.567 10 ( 6.5) hepato (%) 67 (43.5) 0.088 87 (56.5) spiders (%) 109 (70.8) 0.985 45 (29.2) edema (%) 131 (85.1) 0.877 13 ( 8.4) 10 ( 6.5) bili (median [IQR]) 1.30 [0.72, 3.60] 0.842 nonnorm chol (median [IQR]) 303.50 [254.25, 377.00] 0.544 nonnorm albumin (mean (SD)) 3.52 (0.40) 0.874 copper (median [IQR]) 73.00 [43.00, 139.00] 0.717 nonnorm alk.phos (median [IQR]) 1283.00 [922.50, 1949.75] 0.812 nonnorm ast (mean (SD)) 124.97 (58.93) 0.460 trig (median [IQR]) 113.00 [84.50, 155.00] 0.370 nonnorm platelet (mean (SD)) 265.20 (90.73) 0.555 protime (mean (SD)) 10.80 (1.14) 0.197 stage (%) 4 ( 2.6) 0.205 exact 32 (20.8) 64 (41.6) 54 (35.1) Stratified by trt level 1 n 158 time (mean (SD)) 2015.62 (1094.12) status (%) 0 83 (52.5) 1 10 ( 6.3) 2 65 (41.1) age (mean (SD)) 51.42 (11.01) sex (%) m 21 (13.3) f 137 (86.7) ascites (%) 0 144 (91.1) 1 14 ( 8.9) hepato (%) 0 85 (53.8) 1 73 (46.2) spiders (%) 0 113 (71.5) 1 45 (28.5) edema (%) 0 132 (83.5) 0.5 16 (10.1) 1 10 ( 6.3) bili (median [IQR]) 1.40 [0.80, 3.20] chol (median [IQR]) 315.50 [247.75, 417.00] albumin (mean (SD)) 3.52 (0.44) copper (median [IQR]) 73.00 [40.00, 121.00] alk.phos (median [IQR]) 1214.50 [840.75, 2028.00] ast (mean (SD)) 120.21 (54.52) trig (median [IQR]) 106.00 [84.50, 146.00] platelet (mean (SD)) 258.75 (100.32) protime (mean (SD)) 10.65 (0.85) stage (%) 1 12 ( 7.6) 2 35 (22.2) 3 56 (35.4) 4 55 (34.8) Stratified by trt 2 p test n 154 time (mean (SD)) 1996.86 (1155.93) 0.883 status (%) 85 (55.2) 0.884 exact 9 ( 5.8) 60 (39.0) age (mean (SD)) 48.58 (9.96) 0.018 sex (%) 15 ( 9.7) 0.421 139 (90.3) ascites (%) 144 (93.5) 0.567 10 ( 6.5) hepato (%) 67 (43.5) 0.088 87 (56.5) spiders (%) 109 (70.8) 0.985 45 (29.2) edema (%) 131 (85.1) 0.877 13 ( 8.4) 10 ( 6.5) bili (median [IQR]) 1.30 [0.72, 3.60] 0.842 nonnorm chol (median [IQR]) 303.50 [254.25, 377.00] 0.544 nonnorm albumin (mean (SD)) 3.52 (0.40) 0.874 copper (median [IQR]) 73.00 [43.00, 139.00] 0.717 nonnorm alk.phos (median [IQR]) 1283.00 [922.50, 1949.75] 0.812 nonnorm ast (mean (SD)) 124.97 (58.93) 0.460 trig (median [IQR]) 113.00 [84.50, 155.00] 0.370 nonnorm platelet (mean (SD)) 265.20 (90.73) 0.555 protime (mean (SD)) 10.80 (1.14) 0.197 stage (%) 4 ( 2.6) 0.205 exact 32 (20.8) 64 (41.6) 54 (35.1) "Stratified by trt" "" "1" "n" "158" "time (mean (SD))" "2015.62 (1094.12)" "status (%)" "" " 0" "83 (52.5)" " 1" "10 (6.3)" " 2" "65 (41.1)" "age (mean (SD))" "51.42 (11.01)" "sex = f (%)" "137 (86.7)" "ascites = 1 (%)" "14 (8.9)" "hepato = 1 (%)" "73 (46.2)" "spiders = 1 (%)" "45 (28.5)" "edema (%)" "" " 0" "132 (83.5)" " 0.5" "16 (10.1)" " 1" "10 (6.3)" "bili (median [IQR])" "1.40 [0.80, 3.20]" "chol (median [IQR])" "315.50 [247.75, 417.00]" "albumin (mean (SD))" "3.52 (0.44)" "copper (median [IQR])" "73.00 [40.00, 121.00]" "alk.phos (median [IQR])" "1214.50 [840.75, 2028.00]" "ast (mean (SD))" "120.21 (54.52)" "trig (median [IQR])" "106.00 [84.50, 146.00]" "platelet (mean (SD))" "258.75 (100.32)" "protime (mean (SD))" "10.65 (0.85)" "stage (%)" "" " 1" "12 (7.6)" " 2" "35 (22.2)" " 3" "56 (35.4)" " 4" "55 (34.8)" "Stratified by trt" "" "2" "p" "test" "n" "154" "" "" "time (mean (SD))" "1996.86 (1155.93)" "0.883" "" "status (%)" "" "0.884" "exact" " 0" "85 (55.2)" "" "" " 1" "9 (5.8)" "" "" " 2" "60 (39.0)" "" "" "age (mean (SD))" "48.58 (9.96)" "0.018" "" "sex = f (%)" "139 (90.3)" "0.421" "" "ascites = 1 (%)" "10 (6.5)" "0.567" "" "hepato = 1 (%)" "87 (56.5)" "0.088" "" "spiders = 1 (%)" "45 (29.2)" "0.985" "" "edema (%)" "" "0.877" "" " 0" "131 (85.1)" "" "" " 0.5" "13 (8.4)" "" "" " 1" "10 (6.5)" "" "" "bili (median [IQR])" "1.30 [0.72, 3.60]" "0.842" "nonnorm" "chol (median [IQR])" "303.50 [254.25, 377.00]" "0.544" "nonnorm" "albumin (mean (SD))" "3.52 (0.40)" "0.874" "" "copper (median [IQR])" "73.00 [43.00, 139.00]" "0.717" "nonnorm" "alk.phos (median [IQR])" "1283.00 [922.50, 1949.75]" "0.812" "nonnorm" "ast (mean (SD))" "124.97 (58.93)" "0.460" "" "trig (median [IQR])" "113.00 [84.50, 155.00]" "0.370" "nonnorm" "platelet (mean (SD))" "265.20 (90.73)" "0.555" "" "protime (mean (SD))" "10.80 (1.14)" "0.197" "" "stage (%)" "" "0.205" "exact" " 1" "4 (2.6)" "" "" " 2" "32 (20.8)" "" "" " 3" "64 (41.6)" "" "" " 4" "54 (35.1)" "" "" "Stratified by trt" "" "1" "n" "158" "time (mean (SD))" "2015.62 (1094.12)" "status (%)" "" " 0" "83 (52.5)" " 1" "10 (6.3)" " 2" "65 (41.1)" "age (mean (SD))" "51.42 (11.01)" "sex = f (%)" "137 (86.7)" "ascites = 1 (%)" "14 (8.9)" "hepato = 1 (%)" "73 (46.2)" "spiders = 1 (%)" "45 (28.5)" "edema (%)" "" " 0" "132 (83.5)" " 0.5" "16 (10.1)" " 1" "10 (6.3)" "bili (median [IQR])" "1.40 [0.80, 3.20]" "chol (median [IQR])" "315.50 [247.75, 417.00]" "albumin (mean (SD))" "3.52 (0.44)" "copper (median [IQR])" "73.00 [40.00, 121.00]" "alk.phos (median [IQR])" "1214.50 [840.75, 2028.00]" "ast (mean (SD))" "120.21 (54.52)" "trig (median [IQR])" "106.00 [84.50, 146.00]" "platelet (mean (SD))" "258.75 (100.32)" "protime (mean (SD))" "10.65 (0.85)" "stage (%)" "" " 1" "12 (7.6)" " 2" "35 (22.2)" " 3" "56 (35.4)" " 4" "55 (34.8)" "Stratified by trt" "" "2" "p" "test" "n" "154" "" "" "time (mean (SD))" "1996.86 (1155.93)" "0.883" "" "status (%)" "" "0.884" "exact" " 0" "85 (55.2)" "" "" " 1" "9 (5.8)" "" "" " 2" "60 (39.0)" "" "" "age (mean (SD))" "48.58 (9.96)" "0.018" "" "sex = f (%)" "139 (90.3)" "0.421" "" "ascites = 1 (%)" "10 (6.5)" "0.567" "" "hepato = 1 (%)" "87 (56.5)" "0.088" "" "spiders = 1 (%)" "45 (29.2)" "0.985" "" "edema (%)" "" "0.877" "" " 0" "131 (85.1)" "" "" " 0.5" "13 (8.4)" "" "" " 1" "10 (6.5)" "" "" "bili (median [IQR])" "1.30 [0.72, 3.60]" "0.842" "nonnorm" "chol (median [IQR])" "303.50 [254.25, 377.00]" "0.544" "nonnorm" "albumin (mean (SD))" "3.52 (0.40)" "0.874" "" "copper (median [IQR])" "73.00 [43.00, 139.00]" "0.717" "nonnorm" "alk.phos (median [IQR])" "1283.00 [922.50, 1949.75]" "0.812" "nonnorm" "ast (mean (SD))" "124.97 (58.93)" "0.460" "" "trig (median [IQR])" "113.00 [84.50, 155.00]" "0.370" "nonnorm" "platelet (mean (SD))" "265.20 (90.73)" "0.555" "" "protime (mean (SD))" "10.80 (1.14)" "0.197" "" "stage (%)" "" "0.205" "exact" " 1" "4 (2.6)" "" "" " 2" "32 (20.8)" "" "" " 3" "64 (41.6)" "" "" " 4" "54 (35.1)" "" "" Stratified by trt:sex 1:m 2:m 1:f n 21 15 137 time (mean (SD)) 1793.48 (1244.70) 2156.33 (1428.56) 2049.67 (1070.20) age (mean (SD)) 55.57 (12.61) 57.09 (10.07) 50.78 (10.65) protime (mean (SD)) 10.84 (0.94) 11.23 (0.97) 10.62 (0.84) Stratified by trt:sex 2:f p test n 139 time (mean (SD)) 1979.65 (1127.52) 0.730 age (mean (SD)) 47.66 (9.54) <0.001 protime (mean (SD)) 10.75 (1.15) 0.137 Stratified by trt:sex 1:m 2:m 1:f n 21 15 137 time (mean (SD)) 1793.48 (1244.70) 2156.33 (1428.56) 2049.67 (1070.20) age (mean (SD)) 55.57 (12.61) 57.09 (10.07) 50.78 (10.65) protime (mean (SD)) 10.84 (0.94) 11.23 (0.97) 10.62 (0.84) Stratified by trt:sex 2:f p test n 139 time (mean (SD)) 1979.65 (1127.52) 0.730 age (mean (SD)) 47.66 (9.54) <0.001 protime (mean (SD)) 10.75 (1.15) 0.137 Stratified by trt:sex 1:m 2:m 1:f 2:f p test n 21 15 137 139 status (%) 0.033 0 4 (19.0) 7 ( 46.7) 79 ( 57.7) 78 ( 56.1) 1 3 (14.3) 0 ( 0.0) 7 ( 5.1) 9 ( 6.5) 2 14 (66.7) 8 ( 53.3) 51 ( 37.2) 52 ( 37.4) trt = 2 (%) 0 ( 0.0) 15 (100.0) 0 ( 0.0) 139 (100.0) <0.001 sex = f (%) 0 ( 0.0) 0 ( 0.0) 137 (100.0) 139 (100.0) <0.001 Stratified by trt:sex 1:m 2:m 1:f 2:f p test n 21 15 137 139 status (%) 0.033 0 4 (19.0) 7 ( 46.7) 79 ( 57.7) 78 ( 56.1) 1 3 (14.3) 0 ( 0.0) 7 ( 5.1) 9 ( 6.5) 2 14 (66.7) 8 ( 53.3) 51 ( 37.2) 52 ( 37.4) trt = 2 (%) 0 ( 0.0) 15 (100.0) 0 ( 0.0) 139 (100.0) <0.001 sex = f (%) 0 ( 0.0) 0 ( 0.0) 137 (100.0) 139 (100.0) <0.001 "Stratified by trt" "" "Overall" "n" "418" "time (mean (SD))" "1917.78 (1104.67)" "status (%)" "" " 0" "232 (55.5)" " 1" "25 (6.0)" " 2" "161 (38.5)" "age (mean (SD))" "50.74 (10.45)" "sex = f (%)" "374 (89.5)" "ascites = 1 (%)" "24 (7.7)" "hepato = 1 (%)" "160 (51.3)" "spiders = 1 (%)" "90 (28.8)" "edema (%)" "" " 0" "354 (84.7)" " 0.5" "44 (10.5)" " 1" "20 (4.8)" "bili (median [IQR])" "1.40 [0.80, 3.40]" "chol (median [IQR])" "309.50 [249.50, 400.00]" "albumin (mean (SD))" "3.50 (0.42)" "copper (median [IQR])" "73.00 [41.25, 123.00]" "alk.phos (median [IQR])" "1259.00 [871.50, 1980.00]" "ast (mean (SD))" "122.56 (56.70)" "trig (median [IQR])" "108.00 [84.25, 151.00]" "platelet (mean (SD))" "257.02 (98.33)" "protime (mean (SD))" "10.73 (1.02)" "stage (%)" "" " 1" "21 (5.1)" " 2" "92 (22.3)" " 3" "155 (37.6)" " 4" "144 (35.0)" "Stratified by trt" "" "1" "n" "158" "time (mean (SD))" "2015.62 (1094.12)" "status (%)" "" " 0" "83 (52.5)" " 1" "10 (6.3)" " 2" "65 (41.1)" "age (mean (SD))" "51.42 (11.01)" "sex = f (%)" "137 (86.7)" "ascites = 1 (%)" "14 (8.9)" "hepato = 1 (%)" "73 (46.2)" "spiders = 1 (%)" "45 (28.5)" "edema (%)" "" " 0" "132 (83.5)" " 0.5" "16 (10.1)" " 1" "10 (6.3)" "bili (median [IQR])" "1.40 [0.80, 3.20]" "chol (median [IQR])" "315.50 [247.75, 417.00]" "albumin (mean (SD))" "3.52 (0.44)" "copper (median [IQR])" "73.00 [40.00, 121.00]" "alk.phos (median [IQR])" "1214.50 [840.75, 2028.00]" "ast (mean (SD))" "120.21 (54.52)" "trig (median [IQR])" "106.00 [84.50, 146.00]" "platelet (mean (SD))" "258.75 (100.32)" "protime (mean (SD))" "10.65 (0.85)" "stage (%)" "" " 1" "12 (7.6)" " 2" "35 (22.2)" " 3" "56 (35.4)" " 4" "55 (34.8)" "Stratified by trt" "" "2" "p" "test" "n" "154" "" "" "time (mean (SD))" "1996.86 (1155.93)" "0.883" "" "status (%)" "" "0.884" "exact" " 0" "85 (55.2)" "" "" " 1" "9 (5.8)" "" "" " 2" "60 (39.0)" "" "" "age (mean (SD))" "48.58 (9.96)" "0.018" "" "sex = f (%)" "139 (90.3)" "0.421" "" "ascites = 1 (%)" "10 (6.5)" "0.567" "" "hepato = 1 (%)" "87 (56.5)" "0.088" "" "spiders = 1 (%)" "45 (29.2)" "0.985" "" "edema (%)" "" "0.877" "" " 0" "131 (85.1)" "" "" " 0.5" "13 (8.4)" "" "" " 1" "10 (6.5)" "" "" "bili (median [IQR])" "1.30 [0.72, 3.60]" "0.842" "nonnorm" "chol (median [IQR])" "303.50 [254.25, 377.00]" "0.544" "nonnorm" "albumin (mean (SD))" "3.52 (0.40)" "0.874" "" "copper (median [IQR])" "73.00 [43.00, 139.00]" "0.717" "nonnorm" "alk.phos (median [IQR])" "1283.00 [922.50, 1949.75]" "0.812" "nonnorm" "ast (mean (SD))" "124.97 (58.93)" "0.460" "" "trig (median [IQR])" "113.00 [84.50, 155.00]" "0.370" "nonnorm" "platelet (mean (SD))" "265.20 (90.73)" "0.555" "" "protime (mean (SD))" "10.80 (1.14)" "0.197" "" "stage (%)" "" "0.205" "exact" " 1" "4 (2.6)" "" "" " 2" "32 (20.8)" "" "" " 3" "64 (41.6)" "" "" " 4" "54 (35.1)" "" "" "Stratified by trt" "" "SMD" "n" "" "time (mean (SD))" "0.017" "status (%)" "0.054" " 0" "" " 1" "" " 2" "" "age (mean (SD))" "0.270" "sex = f (%)" "0.111" "ascites = 1 (%)" "0.089" "hepato = 1 (%)" "0.207" "spiders = 1 (%)" "0.016" "edema (%)" "0.058" " 0" "" " 0.5" "" " 1" "" "bili (median [IQR])" "0.171" "chol (median [IQR])" "0.038" "albumin (mean (SD))" "0.018" "copper (median [IQR])" "<0.001" "alk.phos (median [IQR])" "0.037" "ast (mean (SD))" "0.084" "trig (median [IQR])" "0.017" "platelet (mean (SD))" "0.067" "protime (mean (SD))" "0.146" "stage (%)" "0.246" " 1" "" " 2" "" " 3" "" " 4" "" "Stratified by trt" "" "Overall" "n" "418" "time (mean (SD))" "1917.78 (1104.67)" "status (%)" "" " 0" "232 (55.5)" " 1" "25 (6.0)" " 2" "161 (38.5)" "age (mean (SD))" "50.74 (10.45)" "sex = f (%)" "374 (89.5)" "ascites = 1 (%)" "24 (7.7)" "hepato = 1 (%)" "160 (51.3)" "spiders = 1 (%)" "90 (28.8)" "edema (%)" "" " 0" "354 (84.7)" " 0.5" "44 (10.5)" " 1" "20 (4.8)" "bili (median [IQR])" "1.40 [0.80, 3.40]" "chol (median [IQR])" "309.50 [249.50, 400.00]" "albumin (mean (SD))" "3.50 (0.42)" "copper (median [IQR])" "73.00 [41.25, 123.00]" "alk.phos (median [IQR])" "1259.00 [871.50, 1980.00]" "ast (mean (SD))" "122.56 (56.70)" "trig (median [IQR])" "108.00 [84.25, 151.00]" "platelet (mean (SD))" "257.02 (98.33)" "protime (mean (SD))" "10.73 (1.02)" "stage (%)" "" " 1" "21 (5.1)" " 2" "92 (22.3)" " 3" "155 (37.6)" " 4" "144 (35.0)" "Stratified by trt" "" "1" "n" "158" "time (mean (SD))" "2015.62 (1094.12)" "status (%)" "" " 0" "83 (52.5)" " 1" "10 (6.3)" " 2" "65 (41.1)" "age (mean (SD))" "51.42 (11.01)" "sex = f (%)" "137 (86.7)" "ascites = 1 (%)" "14 (8.9)" "hepato = 1 (%)" "73 (46.2)" "spiders = 1 (%)" "45 (28.5)" "edema (%)" "" " 0" "132 (83.5)" " 0.5" "16 (10.1)" " 1" "10 (6.3)" "bili (median [IQR])" "1.40 [0.80, 3.20]" "chol (median [IQR])" "315.50 [247.75, 417.00]" "albumin (mean (SD))" "3.52 (0.44)" "copper (median [IQR])" "73.00 [40.00, 121.00]" "alk.phos (median [IQR])" "1214.50 [840.75, 2028.00]" "ast (mean (SD))" "120.21 (54.52)" "trig (median [IQR])" "106.00 [84.50, 146.00]" "platelet (mean (SD))" "258.75 (100.32)" "protime (mean (SD))" "10.65 (0.85)" "stage (%)" "" " 1" "12 (7.6)" " 2" "35 (22.2)" " 3" "56 (35.4)" " 4" "55 (34.8)" "Stratified by trt" "" "2" "p" "test" "n" "154" "" "" "time (mean (SD))" "1996.86 (1155.93)" "0.883" "" "status (%)" "" "0.884" "exact" " 0" "85 (55.2)" "" "" " 1" "9 (5.8)" "" "" " 2" "60 (39.0)" "" "" "age (mean (SD))" "48.58 (9.96)" "0.018" "" "sex = f (%)" "139 (90.3)" "0.421" "" "ascites = 1 (%)" "10 (6.5)" "0.567" "" "hepato = 1 (%)" "87 (56.5)" "0.088" "" "spiders = 1 (%)" "45 (29.2)" "0.985" "" "edema (%)" "" "0.877" "" " 0" "131 (85.1)" "" "" " 0.5" "13 (8.4)" "" "" " 1" "10 (6.5)" "" "" "bili (median [IQR])" "1.30 [0.72, 3.60]" "0.842" "nonnorm" "chol (median [IQR])" "303.50 [254.25, 377.00]" "0.544" "nonnorm" "albumin (mean (SD))" "3.52 (0.40)" "0.874" "" "copper (median [IQR])" "73.00 [43.00, 139.00]" "0.717" "nonnorm" "alk.phos (median [IQR])" "1283.00 [922.50, 1949.75]" "0.812" "nonnorm" "ast (mean (SD))" "124.97 (58.93)" "0.460" "" "trig (median [IQR])" "113.00 [84.50, 155.00]" "0.370" "nonnorm" "platelet (mean (SD))" "265.20 (90.73)" "0.555" "" "protime (mean (SD))" "10.80 (1.14)" "0.197" "" "stage (%)" "" "0.205" "exact" " 1" "4 (2.6)" "" "" " 2" "32 (20.8)" "" "" " 3" "64 (41.6)" "" "" " 4" "54 (35.1)" "" "" "Stratified by trt" "" "SMD" "n" "" "time (mean (SD))" "0.017" "status (%)" "0.054" " 0" "" " 1" "" " 2" "" "age (mean (SD))" "0.270" "sex = f (%)" "0.111" "ascites = 1 (%)" "0.089" "hepato = 1 (%)" "0.207" "spiders = 1 (%)" "0.016" "edema (%)" "0.058" " 0" "" " 0.5" "" " 1" "" "bili (median [IQR])" "0.171" "chol (median [IQR])" "0.038" "albumin (mean (SD))" "0.018" "copper (median [IQR])" "<0.001" "alk.phos (median [IQR])" "0.037" "ast (mean (SD))" "0.084" "trig (median [IQR])" "0.017" "platelet (mean (SD))" "0.067" "protime (mean (SD))" "0.146" "stage (%)" "0.246" " 1" "" " 2" "" " 3" "" " 4" "" Stratified by trt:sex Overall 1:m 2:m n 418 21 15 time (mean (SD)) 1917.78 (1104.67) 1793.48 (1244.70) 2156.33 (1428.56) status (%) 0 232 (55.5) 4 (19.0) 7 (46.7) 1 25 ( 6.0) 3 (14.3) 0 ( 0.0) 2 161 (38.5) 14 (66.7) 8 (53.3) age (mean (SD)) 50.74 (10.45) 55.57 (12.61) 57.09 (10.07) sex = f (%) 374 (89.5) 0 ( 0.0) 0 ( 0.0) ascites = 1 (%) 24 ( 7.7) 1 ( 4.8) 2 (13.3) hepato = 1 (%) 160 (51.3) 12 (57.1) 9 (60.0) spiders = 1 (%) 90 (28.8) 3 (14.3) 1 ( 6.7) edema (%) 0 354 (84.7) 17 (81.0) 12 (80.0) 0.5 44 (10.5) 3 (14.3) 1 ( 6.7) 1 20 ( 4.8) 1 ( 4.8) 2 (13.3) bili (mean (SD)) 3.22 (4.41) 2.98 (2.11) 2.72 (2.46) chol (mean (SD)) 369.51 (231.94) 403.43 (204.95) 301.00 (111.32) albumin (mean (SD)) 3.50 (0.42) 3.63 (0.43) 3.50 (0.49) copper (mean (SD)) 97.65 (85.61) 174.90 (105.33) 125.40 (89.18) alk.phos (mean (SD)) 1982.66 (2140.39) 2486.16 (2385.32) 1734.45 (2478.07) ast (mean (SD)) 122.56 (56.70) 128.71 (48.74) 112.58 (44.38) trig (mean (SD)) 124.70 (65.15) 145.81 (56.62) 114.86 (39.59) platelet (mean (SD)) 257.02 (98.33) 232.65 (97.38) 240.13 (73.93) protime (mean (SD)) 10.73 (1.02) 10.84 (0.94) 11.23 (0.97) stage (%) 1 21 ( 5.1) 2 ( 9.5) 1 ( 6.7) 2 92 (22.3) 4 (19.0) 2 (13.3) 3 155 (37.6) 7 (33.3) 5 (33.3) 4 144 (35.0) 8 (38.1) 7 (46.7) Stratified by trt:sex 1:f 2:f p test SMD n 137 139 time (mean (SD)) 2049.67 (1070.20) 1979.65 (1127.52) 0.730 0.156 status (%) 0.033 0.577 0 79 ( 57.7) 78 ( 56.1) 1 7 ( 5.1) 9 ( 6.5) 2 51 ( 37.2) 52 ( 37.4) age (mean (SD)) 50.78 (10.65) 47.66 (9.54) <0.001 0.521 sex = f (%) 137 (100.0) 139 (100.0) <0.001 NaN ascites = 1 (%) 13 ( 9.5) 8 ( 5.8) 0.516 0.176 hepato = 1 (%) 61 ( 44.5) 78 ( 56.1) 0.208 0.160 spiders = 1 (%) 42 ( 30.7) 44 ( 31.7) 0.089 0.402 edema (%) 0.906 0.212 0 115 ( 83.9) 119 ( 85.6) 0.5 13 ( 9.5) 12 ( 8.6) 1 9 ( 6.6) 8 ( 5.8) bili (mean (SD)) 2.86 (3.81) 3.75 (5.50) 0.394 0.135 chol (mean (SD)) 358.24 (210.46) 381.73 (262.26) 0.512 0.295 albumin (mean (SD)) 3.50 (0.44) 3.53 (0.39) 0.585 0.164 copper (mean (SD)) 85.71 (82.27) 94.64 (79.25) <0.001 0.542 alk.phos (mean (SD)) 1950.04 (2151.35) 1965.52 (2066.15) 0.706 0.163 ast (mean (SD)) 118.91 (55.40) 126.30 (60.27) 0.598 0.182 trig (mean (SD)) 120.28 (73.41) 126.38 (60.22) 0.370 0.294 platelet (mean (SD)) 262.59 (100.53) 267.95 (92.20) 0.362 0.234 protime (mean (SD)) 10.62 (0.84) 10.75 (1.15) 0.137 0.328 stage (%) 0.646 0.277 1 10 ( 7.3) 3 ( 2.2) 2 31 ( 22.6) 30 ( 21.6) 3 49 ( 35.8) 59 ( 42.4) 4 47 ( 34.3) 47 ( 33.8) Stratified by trt:sex Overall 1:m 2:m n 418 21 15 time (mean (SD)) 1917.78 (1104.67) 1793.48 (1244.70) 2156.33 (1428.56) status (%) 0 232 (55.5) 4 (19.0) 7 (46.7) 1 25 ( 6.0) 3 (14.3) 0 ( 0.0) 2 161 (38.5) 14 (66.7) 8 (53.3) age (mean (SD)) 50.74 (10.45) 55.57 (12.61) 57.09 (10.07) sex = f (%) 374 (89.5) 0 ( 0.0) 0 ( 0.0) ascites = 1 (%) 24 ( 7.7) 1 ( 4.8) 2 (13.3) hepato = 1 (%) 160 (51.3) 12 (57.1) 9 (60.0) spiders = 1 (%) 90 (28.8) 3 (14.3) 1 ( 6.7) edema (%) 0 354 (84.7) 17 (81.0) 12 (80.0) 0.5 44 (10.5) 3 (14.3) 1 ( 6.7) 1 20 ( 4.8) 1 ( 4.8) 2 (13.3) bili (mean (SD)) 3.22 (4.41) 2.98 (2.11) 2.72 (2.46) chol (mean (SD)) 369.51 (231.94) 403.43 (204.95) 301.00 (111.32) albumin (mean (SD)) 3.50 (0.42) 3.63 (0.43) 3.50 (0.49) copper (mean (SD)) 97.65 (85.61) 174.90 (105.33) 125.40 (89.18) alk.phos (mean (SD)) 1982.66 (2140.39) 2486.16 (2385.32) 1734.45 (2478.07) ast (mean (SD)) 122.56 (56.70) 128.71 (48.74) 112.58 (44.38) trig (mean (SD)) 124.70 (65.15) 145.81 (56.62) 114.86 (39.59) platelet (mean (SD)) 257.02 (98.33) 232.65 (97.38) 240.13 (73.93) protime (mean (SD)) 10.73 (1.02) 10.84 (0.94) 11.23 (0.97) stage (%) 1 21 ( 5.1) 2 ( 9.5) 1 ( 6.7) 2 92 (22.3) 4 (19.0) 2 (13.3) 3 155 (37.6) 7 (33.3) 5 (33.3) 4 144 (35.0) 8 (38.1) 7 (46.7) Stratified by trt:sex 1:f 2:f p test SMD n 137 139 time (mean (SD)) 2049.67 (1070.20) 1979.65 (1127.52) 0.730 0.156 status (%) 0.033 0.577 0 79 ( 57.7) 78 ( 56.1) 1 7 ( 5.1) 9 ( 6.5) 2 51 ( 37.2) 52 ( 37.4) age (mean (SD)) 50.78 (10.65) 47.66 (9.54) <0.001 0.521 sex = f (%) 137 (100.0) 139 (100.0) <0.001 NaN ascites = 1 (%) 13 ( 9.5) 8 ( 5.8) 0.516 0.176 hepato = 1 (%) 61 ( 44.5) 78 ( 56.1) 0.208 0.160 spiders = 1 (%) 42 ( 30.7) 44 ( 31.7) 0.089 0.402 edema (%) 0.906 0.212 0 115 ( 83.9) 119 ( 85.6) 0.5 13 ( 9.5) 12 ( 8.6) 1 9 ( 6.6) 8 ( 5.8) bili (mean (SD)) 2.86 (3.81) 3.75 (5.50) 0.394 0.135 chol (mean (SD)) 358.24 (210.46) 381.73 (262.26) 0.512 0.295 albumin (mean (SD)) 3.50 (0.44) 3.53 (0.39) 0.585 0.164 copper (mean (SD)) 85.71 (82.27) 94.64 (79.25) <0.001 0.542 alk.phos (mean (SD)) 1950.04 (2151.35) 1965.52 (2066.15) 0.706 0.163 ast (mean (SD)) 118.91 (55.40) 126.30 (60.27) 0.598 0.182 trig (mean (SD)) 120.28 (73.41) 126.38 (60.22) 0.370 0.294 platelet (mean (SD)) 262.59 (100.53) 267.95 (92.20) 0.362 0.234 protime (mean (SD)) 10.62 (0.84) 10.75 (1.15) 0.137 0.328 stage (%) 0.646 0.277 1 10 ( 7.3) 3 ( 2.2) 2 31 ( 22.6) 30 ( 21.6) 3 49 ( 35.8) 59 ( 42.4) 4 47 ( 34.3) 47 ( 33.8) Stratified by trt:sex Overall 1:m 2:m n 418 21 15 time (mean (SD)) 1917.78 (1104.67) 1793.48 (1244.70) 2156.33 (1428.56) age (mean (SD)) 50.74 (10.45) 55.57 (12.61) 57.09 (10.07) protime (mean (SD)) 10.73 (1.02) 10.84 (0.94) 11.23 (0.97) Stratified by trt:sex 1:f 2:f p test SMD n 137 139 time (mean (SD)) 2049.67 (1070.20) 1979.65 (1127.52) 0.730 0.156 age (mean (SD)) 50.78 (10.65) 47.66 (9.54) <0.001 0.521 protime (mean (SD)) 10.62 (0.84) 10.75 (1.15) 0.137 0.328 Stratified by trt:sex Overall 1:m 2:m n 418 21 15 time (mean (SD)) 1917.78 (1104.67) 1793.48 (1244.70) 2156.33 (1428.56) age (mean (SD)) 50.74 (10.45) 55.57 (12.61) 57.09 (10.07) protime (mean (SD)) 10.73 (1.02) 10.84 (0.94) 11.23 (0.97) Stratified by trt:sex 1:f 2:f p test SMD n 137 139 time (mean (SD)) 2049.67 (1070.20) 1979.65 (1127.52) 0.730 0.156 age (mean (SD)) 50.78 (10.65) 47.66 (9.54) <0.001 0.521 protime (mean (SD)) 10.62 (0.84) 10.75 (1.15) 0.137 0.328 Stratified by trt:sex Overall 1:m 2:m 1:f 2:f n 418 21 15 137 139 status (%) 0 232 (55.5) 4 (19.0) 7 ( 46.7) 79 ( 57.7) 78 ( 56.1) 1 25 ( 6.0) 3 (14.3) 0 ( 0.0) 7 ( 5.1) 9 ( 6.5) 2 161 (38.5) 14 (66.7) 8 ( 53.3) 51 ( 37.2) 52 ( 37.4) trt = 2 (%) 154 (49.4) 0 ( 0.0) 15 (100.0) 0 ( 0.0) 139 (100.0) sex = f (%) 374 (89.5) 0 ( 0.0) 0 ( 0.0) 137 (100.0) 139 (100.0) Stratified by trt:sex p test SMD n status (%) 0.033 0.577 0 1 2 trt = 2 (%) <0.001 NaN sex = f (%) <0.001 NaN Stratified by trt:sex Overall 1:m 2:m 1:f 2:f n 418 21 15 137 139 status (%) 0 232 (55.5) 4 (19.0) 7 ( 46.7) 79 ( 57.7) 78 ( 56.1) 1 25 ( 6.0) 3 (14.3) 0 ( 0.0) 7 ( 5.1) 9 ( 6.5) 2 161 (38.5) 14 (66.7) 8 ( 53.3) 51 ( 37.2) 52 ( 37.4) trt = 2 (%) 154 (49.4) 0 ( 0.0) 15 (100.0) 0 ( 0.0) 139 (100.0) sex = f (%) 374 (89.5) 0 ( 0.0) 0 ( 0.0) 137 (100.0) 139 (100.0) Stratified by trt:sex p test SMD n status (%) 0.033 0.577 0 1 2 trt = 2 (%) <0.001 NaN sex = f (%) <0.001 NaN "Stratified by trt" "" "Overall" "n" "4,18" "time (mean (SD))" "19,17D78 (11,04D67)" "status (%)" "" " 0" "232 (55D5)" " 1" "25 (6D0)" " 2" "161 (38D5)" "age (mean (SD))" "50D74 (10D45)" "sex = f (%)" "374 (89D5)" "ascites = 1 (%)" "24 (7D7)" "hepato = 1 (%)" "160 (51D3)" "spiders = 1 (%)" "90 (28D8)" "edema (%)" "" " 0" "354 (84D7)" " 0.5" "44 (10D5)" " 1" "20 (4D8)" "bili (median [IQR])" "1D40 [0D80, 3D40]" "chol (median [IQR])" "3,09D50 [2,49D50, 4,00D00]" "albumin (mean (SD))" "3D50 (0D42)" "copper (median [IQR])" "73D00 [41D25, 1,23D00]" "alk.phos (median [IQR])" "12,59D00 [8,71D50, 19,80D00]" "ast (mean (SD))" "1,22D56 (56D70)" "trig (median [IQR])" "1,08D00 [84D25, 1,51D00]" "platelet (mean (SD))" "2,57D02 (98D33)" "protime (mean (SD))" "10D73 (1D02)" "stage (%)" "" " 1" "21 (5D1)" " 2" "92 (22D3)" " 3" "155 (37D6)" " 4" "144 (35D0)" "Stratified by trt" "" "1" "n" "1,58" "time (mean (SD))" "20,15D62 (10,94D12)" "status (%)" "" " 0" "83 (52D5)" " 1" "10 (6D3)" " 2" "65 (41D1)" "age (mean (SD))" "51D42 (11D01)" "sex = f (%)" "137 (86D7)" "ascites = 1 (%)" "14 (8D9)" "hepato = 1 (%)" "73 (46D2)" "spiders = 1 (%)" "45 (28D5)" "edema (%)" "" " 0" "132 (83D5)" " 0.5" "16 (10D1)" " 1" "10 (6D3)" "bili (median [IQR])" "1D40 [0D80, 3D20]" "chol (median [IQR])" "3,15D50 [2,47D75, 4,17D00]" "albumin (mean (SD))" "3D52 (0D44)" "copper (median [IQR])" "73D00 [40D00, 1,21D00]" "alk.phos (median [IQR])" "12,14D50 [8,40D75, 20,28D00]" "ast (mean (SD))" "1,20D21 (54D52)" "trig (median [IQR])" "1,06D00 [84D50, 1,46D00]" "platelet (mean (SD))" "2,58D75 (1,00D32)" "protime (mean (SD))" "10D65 (0D85)" "stage (%)" "" " 1" "12 (7D6)" " 2" "35 (22D2)" " 3" "56 (35D4)" " 4" "55 (34D8)" "Stratified by trt" "" "2" "p" "test" "n" "1,54" "" "" "time (mean (SD))" "19,96D86 (11,55D93)" "0D883" "" "status (%)" "" "0D884" "exact" " 0" "85 (55D2)" "" "" " 1" "9 (5D8)" "" "" " 2" "60 (39D0)" "" "" "age (mean (SD))" "48D58 (9D96)" "0D018" "" "sex = f (%)" "139 (90D3)" "0D421" "" "ascites = 1 (%)" "10 (6D5)" "0D567" "" "hepato = 1 (%)" "87 (56D5)" "0D088" "" "spiders = 1 (%)" "45 (29D2)" "0D985" "" "edema (%)" "" "0D877" "" " 0" "131 (85D1)" "" "" " 0.5" "13 (8D4)" "" "" " 1" "10 (6D5)" "" "" "bili (median [IQR])" "1D30 [0D72, 3D60]" "0D842" "nonnorm" "chol (median [IQR])" "3,03D50 [2,54D25, 3,77D00]" "0D544" "nonnorm" "albumin (mean (SD))" "3D52 (0D40)" "0D874" "" "copper (median [IQR])" "73D00 [43D00, 1,39D00]" "0D717" "nonnorm" "alk.phos (median [IQR])" "12,83D00 [9,22D50, 19,49D75]" "0D812" "nonnorm" "ast (mean (SD))" "1,24D97 (58D93)" "0D460" "" "trig (median [IQR])" "1,13D00 [84D50, 1,55D00]" "0D370" "nonnorm" "platelet (mean (SD))" "2,65D20 (90D73)" "0D555" "" "protime (mean (SD))" "10D80 (1D14)" "0D197" "" "stage (%)" "" "0D205" "exact" " 1" "4 (2D6)" "" "" " 2" "32 (20D8)" "" "" " 3" "64 (41D6)" "" "" " 4" "54 (35D1)" "" "" "Stratified by trt" "" "SMD" "n" "" "time (mean (SD))" "0D017" "status (%)" "0D054" " 0" "" " 1" "" " 2" "" "age (mean (SD))" "0D270" "sex = f (%)" "0D111" "ascites = 1 (%)" "0D089" "hepato = 1 (%)" "0D207" "spiders = 1 (%)" "0D016" "edema (%)" "0D058" " 0" "" " 0.5" "" " 1" "" "bili (median [IQR])" "0D171" "chol (median [IQR])" "0D038" "albumin (mean (SD))" "0D018" "copper (median [IQR])" "<0D001" "alk.phos (median [IQR])" "0D037" "ast (mean (SD))" "0D084" "trig (median [IQR])" "0D017" "platelet (mean (SD))" "0D067" "protime (mean (SD))" "0D146" "stage (%)" "0D246" " 1" "" " 2" "" " 3" "" " 4" "" "Stratified by trt" "" "Overall" "n" "4,18" "time (mean (SD))" "19,17D78 (11,04D67)" "status (%)" "" " 0" "232 (55D5)" " 1" "25 (6D0)" " 2" "161 (38D5)" "age (mean (SD))" "50D74 (10D45)" "sex = f (%)" "374 (89D5)" "ascites = 1 (%)" "24 (7D7)" "hepato = 1 (%)" "160 (51D3)" "spiders = 1 (%)" "90 (28D8)" "edema (%)" "" " 0" "354 (84D7)" " 0.5" "44 (10D5)" " 1" "20 (4D8)" "bili (median [IQR])" "1D40 [0D80, 3D40]" "chol (median [IQR])" "3,09D50 [2,49D50, 4,00D00]" "albumin (mean (SD))" "3D50 (0D42)" "copper (median [IQR])" "73D00 [41D25, 1,23D00]" "alk.phos (median [IQR])" "12,59D00 [8,71D50, 19,80D00]" "ast (mean (SD))" "1,22D56 (56D70)" "trig (median [IQR])" "1,08D00 [84D25, 1,51D00]" "platelet (mean (SD))" "2,57D02 (98D33)" "protime (mean (SD))" "10D73 (1D02)" "stage (%)" "" " 1" "21 (5D1)" " 2" "92 (22D3)" " 3" "155 (37D6)" " 4" "144 (35D0)" "Stratified by trt" "" "1" "n" "1,58" "time (mean (SD))" "20,15D62 (10,94D12)" "status (%)" "" " 0" "83 (52D5)" " 1" "10 (6D3)" " 2" "65 (41D1)" "age (mean (SD))" "51D42 (11D01)" "sex = f (%)" "137 (86D7)" "ascites = 1 (%)" "14 (8D9)" "hepato = 1 (%)" "73 (46D2)" "spiders = 1 (%)" "45 (28D5)" "edema (%)" "" " 0" "132 (83D5)" " 0.5" "16 (10D1)" " 1" "10 (6D3)" "bili (median [IQR])" "1D40 [0D80, 3D20]" "chol (median [IQR])" "3,15D50 [2,47D75, 4,17D00]" "albumin (mean (SD))" "3D52 (0D44)" "copper (median [IQR])" "73D00 [40D00, 1,21D00]" "alk.phos (median [IQR])" "12,14D50 [8,40D75, 20,28D00]" "ast (mean (SD))" "1,20D21 (54D52)" "trig (median [IQR])" "1,06D00 [84D50, 1,46D00]" "platelet (mean (SD))" "2,58D75 (1,00D32)" "protime (mean (SD))" "10D65 (0D85)" "stage (%)" "" " 1" "12 (7D6)" " 2" "35 (22D2)" " 3" "56 (35D4)" " 4" "55 (34D8)" "Stratified by trt" "" "2" "p" "test" "n" "1,54" "" "" "time (mean (SD))" "19,96D86 (11,55D93)" "0D883" "" "status (%)" "" "0D884" "exact" " 0" "85 (55D2)" "" "" " 1" "9 (5D8)" "" "" " 2" "60 (39D0)" "" "" "age (mean (SD))" "48D58 (9D96)" "0D018" "" "sex = f (%)" "139 (90D3)" "0D421" "" "ascites = 1 (%)" "10 (6D5)" "0D567" "" "hepato = 1 (%)" "87 (56D5)" "0D088" "" "spiders = 1 (%)" "45 (29D2)" "0D985" "" "edema (%)" "" "0D877" "" " 0" "131 (85D1)" "" "" " 0.5" "13 (8D4)" "" "" " 1" "10 (6D5)" "" "" "bili (median [IQR])" "1D30 [0D72, 3D60]" "0D842" "nonnorm" "chol (median [IQR])" "3,03D50 [2,54D25, 3,77D00]" "0D544" "nonnorm" "albumin (mean (SD))" "3D52 (0D40)" "0D874" "" "copper (median [IQR])" "73D00 [43D00, 1,39D00]" "0D717" "nonnorm" "alk.phos (median [IQR])" "12,83D00 [9,22D50, 19,49D75]" "0D812" "nonnorm" "ast (mean (SD))" "1,24D97 (58D93)" "0D460" "" "trig (median [IQR])" "1,13D00 [84D50, 1,55D00]" "0D370" "nonnorm" "platelet (mean (SD))" "2,65D20 (90D73)" "0D555" "" "protime (mean (SD))" "10D80 (1D14)" "0D197" "" "stage (%)" "" "0D205" "exact" " 1" "4 (2D6)" "" "" " 2" "32 (20D8)" "" "" " 3" "64 (41D6)" "" "" " 4" "54 (35D1)" "" "" "Stratified by trt" "" "SMD" "n" "" "time (mean (SD))" "0D017" "status (%)" "0D054" " 0" "" " 1" "" " 2" "" "age (mean (SD))" "0D270" "sex = f (%)" "0D111" "ascites = 1 (%)" "0D089" "hepato = 1 (%)" "0D207" "spiders = 1 (%)" "0D016" "edema (%)" "0D058" " 0" "" " 0.5" "" " 1" "" "bili (median [IQR])" "0D171" "chol (median [IQR])" "0D038" "albumin (mean (SD))" "0D018" "copper (median [IQR])" "<0D001" "alk.phos (median [IQR])" "0D037" "ast (mean (SD))" "0D084" "trig (median [IQR])" "0D017" "platelet (mean (SD))" "0D067" "protime (mean (SD))" "0D146" "stage (%)" "0D246" " 1" "" " 2" "" " 3" "" " 4" "" Stratified by trt:sex Overall 1:m n 4,18 21 time (mean (SD)) 19,17D78 (11,04D67) 17,93D48 (12,44D70) status (%) 0 232 (55D5) 4 (19D0) 1 25 ( 6D0) 3 (14D3) 2 161 (38D5) 14 (66D7) age (mean (SD)) 50D74 (10D45) 55D57 (12D61) sex = f (%) 374 (89D5) 0 ( 0D0) ascites = 1 (%) 24 ( 7D7) 1 ( 4D8) hepato = 1 (%) 160 (51D3) 12 (57D1) spiders = 1 (%) 90 (28D8) 3 (14D3) edema (%) 0 354 (84D7) 17 (81D0) 0.5 44 (10D5) 3 (14D3) 1 20 ( 4D8) 1 ( 4D8) bili (mean (SD)) 3D22 (4D41) 2D98 (2D11) chol (mean (SD)) 3,69D51 (2,31D94) 4,03D43 (2,04D95) albumin (mean (SD)) 3D50 (0D42) 3D63 (0D43) copper (mean (SD)) 97D65 (85D61) 1,74D90 (1,05D33) alk.phos (mean (SD)) 19,82D66 (21,40D39) 24,86D16 (23,85D32) ast (mean (SD)) 1,22D56 (56D70) 1,28D71 (48D74) trig (mean (SD)) 1,24D70 (65D15) 1,45D81 (56D62) platelet (mean (SD)) 2,57D02 (98D33) 2,32D65 (97D38) protime (mean (SD)) 10D73 (1D02) 10D84 (0D94) stage (%) 1 21 ( 5D1) 2 ( 9D5) 2 92 (22D3) 4 (19D0) 3 155 (37D6) 7 (33D3) 4 144 (35D0) 8 (38D1) Stratified by trt:sex 2:m 1:f n 15 1,37 time (mean (SD)) 21,56D33 (14,28D56) 20,49D67 (10,70D20) status (%) 0 7 (46D7) 79 ( 57D7) 1 0 ( 0D0) 7 ( 5D1) 2 8 (53D3) 51 ( 37D2) age (mean (SD)) 57D09 (10D07) 50D78 (10D65) sex = f (%) 0 ( 0D0) 137 (1,00D0) ascites = 1 (%) 2 (13D3) 13 ( 9D5) hepato = 1 (%) 9 (60D0) 61 ( 44D5) spiders = 1 (%) 1 ( 6D7) 42 ( 30D7) edema (%) 0 12 (80D0) 115 ( 83D9) 0.5 1 ( 6D7) 13 ( 9D5) 1 2 (13D3) 9 ( 6D6) bili (mean (SD)) 2D72 (2D46) 2D86 (3D81) chol (mean (SD)) 3,01D00 (1,11D32) 3,58D24 (2,10D46) albumin (mean (SD)) 3D50 (0D49) 3D50 (0D44) copper (mean (SD)) 1,25D40 (89D18) 85D71 (82D27) alk.phos (mean (SD)) 17,34D45 (24,78D07) 19,50D04 (21,51D35) ast (mean (SD)) 1,12D58 (44D38) 1,18D91 (55D40) trig (mean (SD)) 1,14D86 (39D59) 1,20D28 (73D41) platelet (mean (SD)) 2,40D13 (73D93) 2,62D59 (1,00D53) protime (mean (SD)) 11D23 (0D97) 10D62 (0D84) stage (%) 1 1 ( 6D7) 10 ( 7D3) 2 2 (13D3) 31 ( 22D6) 3 5 (33D3) 49 ( 35D8) 4 7 (46D7) 47 ( 34D3) Stratified by trt:sex 2:f p test SMD n 1,39 time (mean (SD)) 19,79D65 (11,27D52) 0D730 0D156 status (%) 0D033 0D577 0 78 ( 56D1) 1 9 ( 6D5) 2 52 ( 37D4) age (mean (SD)) 47D66 (9D54) <0D001 0D521 sex = f (%) 139 (1,00D0) <0D001 NaN ascites = 1 (%) 8 ( 5D8) 0D516 0D176 hepato = 1 (%) 78 ( 56D1) 0D208 0D160 spiders = 1 (%) 44 ( 31D7) 0D089 0D402 edema (%) 0D906 0D212 0 119 ( 85D6) 0.5 12 ( 8D6) 1 8 ( 5D8) bili (mean (SD)) 3D75 (5D50) 0D394 0D135 chol (mean (SD)) 3,81D73 (2,62D26) 0D512 0D295 albumin (mean (SD)) 3D53 (0D39) 0D585 0D164 copper (mean (SD)) 94D64 (79D25) <0D001 0D542 alk.phos (mean (SD)) 19,65D52 (20,66D15) 0D706 0D163 ast (mean (SD)) 1,26D30 (60D27) 0D598 0D182 trig (mean (SD)) 1,26D38 (60D22) 0D370 0D294 platelet (mean (SD)) 2,67D95 (92D20) 0D362 0D234 protime (mean (SD)) 10D75 (1D15) 0D137 0D328 stage (%) 0D646 0D277 1 3 ( 2D2) 2 30 ( 21D6) 3 59 ( 42D4) 4 47 ( 33D8) Stratified by trt:sex Overall 1:m n 4,18 21 time (mean (SD)) 19,17D78 (11,04D67) 17,93D48 (12,44D70) status (%) 0 232 (55D5) 4 (19D0) 1 25 ( 6D0) 3 (14D3) 2 161 (38D5) 14 (66D7) age (mean (SD)) 50D74 (10D45) 55D57 (12D61) sex = f (%) 374 (89D5) 0 ( 0D0) ascites = 1 (%) 24 ( 7D7) 1 ( 4D8) hepato = 1 (%) 160 (51D3) 12 (57D1) spiders = 1 (%) 90 (28D8) 3 (14D3) edema (%) 0 354 (84D7) 17 (81D0) 0.5 44 (10D5) 3 (14D3) 1 20 ( 4D8) 1 ( 4D8) bili (mean (SD)) 3D22 (4D41) 2D98 (2D11) chol (mean (SD)) 3,69D51 (2,31D94) 4,03D43 (2,04D95) albumin (mean (SD)) 3D50 (0D42) 3D63 (0D43) copper (mean (SD)) 97D65 (85D61) 1,74D90 (1,05D33) alk.phos (mean (SD)) 19,82D66 (21,40D39) 24,86D16 (23,85D32) ast (mean (SD)) 1,22D56 (56D70) 1,28D71 (48D74) trig (mean (SD)) 1,24D70 (65D15) 1,45D81 (56D62) platelet (mean (SD)) 2,57D02 (98D33) 2,32D65 (97D38) protime (mean (SD)) 10D73 (1D02) 10D84 (0D94) stage (%) 1 21 ( 5D1) 2 ( 9D5) 2 92 (22D3) 4 (19D0) 3 155 (37D6) 7 (33D3) 4 144 (35D0) 8 (38D1) Stratified by trt:sex 2:m 1:f n 15 1,37 time (mean (SD)) 21,56D33 (14,28D56) 20,49D67 (10,70D20) status (%) 0 7 (46D7) 79 ( 57D7) 1 0 ( 0D0) 7 ( 5D1) 2 8 (53D3) 51 ( 37D2) age (mean (SD)) 57D09 (10D07) 50D78 (10D65) sex = f (%) 0 ( 0D0) 137 (1,00D0) ascites = 1 (%) 2 (13D3) 13 ( 9D5) hepato = 1 (%) 9 (60D0) 61 ( 44D5) spiders = 1 (%) 1 ( 6D7) 42 ( 30D7) edema (%) 0 12 (80D0) 115 ( 83D9) 0.5 1 ( 6D7) 13 ( 9D5) 1 2 (13D3) 9 ( 6D6) bili (mean (SD)) 2D72 (2D46) 2D86 (3D81) chol (mean (SD)) 3,01D00 (1,11D32) 3,58D24 (2,10D46) albumin (mean (SD)) 3D50 (0D49) 3D50 (0D44) copper (mean (SD)) 1,25D40 (89D18) 85D71 (82D27) alk.phos (mean (SD)) 17,34D45 (24,78D07) 19,50D04 (21,51D35) ast (mean (SD)) 1,12D58 (44D38) 1,18D91 (55D40) trig (mean (SD)) 1,14D86 (39D59) 1,20D28 (73D41) platelet (mean (SD)) 2,40D13 (73D93) 2,62D59 (1,00D53) protime (mean (SD)) 11D23 (0D97) 10D62 (0D84) stage (%) 1 1 ( 6D7) 10 ( 7D3) 2 2 (13D3) 31 ( 22D6) 3 5 (33D3) 49 ( 35D8) 4 7 (46D7) 47 ( 34D3) Stratified by trt:sex 2:f p test SMD n 1,39 time (mean (SD)) 19,79D65 (11,27D52) 0D730 0D156 status (%) 0D033 0D577 0 78 ( 56D1) 1 9 ( 6D5) 2 52 ( 37D4) age (mean (SD)) 47D66 (9D54) <0D001 0D521 sex = f (%) 139 (1,00D0) <0D001 NaN ascites = 1 (%) 8 ( 5D8) 0D516 0D176 hepato = 1 (%) 78 ( 56D1) 0D208 0D160 spiders = 1 (%) 44 ( 31D7) 0D089 0D402 edema (%) 0D906 0D212 0 119 ( 85D6) 0.5 12 ( 8D6) 1 8 ( 5D8) bili (mean (SD)) 3D75 (5D50) 0D394 0D135 chol (mean (SD)) 3,81D73 (2,62D26) 0D512 0D295 albumin (mean (SD)) 3D53 (0D39) 0D585 0D164 copper (mean (SD)) 94D64 (79D25) <0D001 0D542 alk.phos (mean (SD)) 19,65D52 (20,66D15) 0D706 0D163 ast (mean (SD)) 1,26D30 (60D27) 0D598 0D182 trig (mean (SD)) 1,26D38 (60D22) 0D370 0D294 platelet (mean (SD)) 2,67D95 (92D20) 0D362 0D234 protime (mean (SD)) 10D75 (1D15) 0D137 0D328 stage (%) 0D646 0D277 1 3 ( 2D2) 2 30 ( 21D6) 3 59 ( 42D4) 4 47 ( 33D8) Stratified by trt:sex Overall 1:m n 4,18 21 time (mean (SD)) 19,17D78 (11,04D67) 17,93D48 (12,44D70) age (mean (SD)) 50D74 (10D45) 55D57 (12D61) protime (mean (SD)) 10D73 (1D02) 10D84 (0D94) Stratified by trt:sex 2:m 1:f n 15 1,37 time (mean (SD)) 21,56D33 (14,28D56) 20,49D67 (10,70D20) age (mean (SD)) 57D09 (10D07) 50D78 (10D65) protime (mean (SD)) 11D23 (0D97) 10D62 (0D84) Stratified by trt:sex 2:f p test SMD n 1,39 time (mean (SD)) 19,79D65 (11,27D52) 0D730 0D156 age (mean (SD)) 47D66 (9D54) <0D001 0D521 protime (mean (SD)) 10D75 (1D15) 0D137 0D328 Stratified by trt:sex Overall 1:m n 4,18 21 time (mean (SD)) 19,17D78 (11,04D67) 17,93D48 (12,44D70) age (mean (SD)) 50D74 (10D45) 55D57 (12D61) protime (mean (SD)) 10D73 (1D02) 10D84 (0D94) Stratified by trt:sex 2:m 1:f n 15 1,37 time (mean (SD)) 21,56D33 (14,28D56) 20,49D67 (10,70D20) age (mean (SD)) 57D09 (10D07) 50D78 (10D65) protime (mean (SD)) 11D23 (0D97) 10D62 (0D84) Stratified by trt:sex 2:f p test SMD n 1,39 time (mean (SD)) 19,79D65 (11,27D52) 0D730 0D156 age (mean (SD)) 47D66 (9D54) <0D001 0D521 protime (mean (SD)) 10D75 (1D15) 0D137 0D328 Stratified by trt:sex Overall 1:m 2:m 1:f n 4,18 21 15 1,37 status (%) 0 232 (55D5) 4 (19D0) 7 ( 46D7) 79 ( 57D7) 1 25 ( 6D0) 3 (14D3) 0 ( 0D0) 7 ( 5D1) 2 161 (38D5) 14 (66D7) 8 ( 53D3) 51 ( 37D2) trt = 2 (%) 154 (49D4) 0 ( 0D0) 15 (1,00D0) 0 ( 0D0) sex = f (%) 374 (89D5) 0 ( 0D0) 0 ( 0D0) 137 (1,00D0) Stratified by trt:sex 2:f p test SMD n 1,39 status (%) 0D033 0D577 0 78 ( 56D1) 1 9 ( 6D5) 2 52 ( 37D4) trt = 2 (%) 139 (1,00D0) <0D001 NaN sex = f (%) 139 (1,00D0) <0D001 NaN Stratified by trt:sex Overall 1:m 2:m 1:f n 4,18 21 15 1,37 status (%) 0 232 (55D5) 4 (19D0) 7 ( 46D7) 79 ( 57D7) 1 25 ( 6D0) 3 (14D3) 0 ( 0D0) 7 ( 5D1) 2 161 (38D5) 14 (66D7) 8 ( 53D3) 51 ( 37D2) trt = 2 (%) 154 (49D4) 0 ( 0D0) 15 (1,00D0) 0 ( 0D0) sex = f (%) 374 (89D5) 0 ( 0D0) 0 ( 0D0) 137 (1,00D0) Stratified by trt:sex 2:f p test SMD n 1,39 status (%) 0D033 0D577 0 78 ( 56D1) 1 9 ( 6D5) 2 52 ( 37D4) trt = 2 (%) 139 (1,00D0) <0D001 NaN sex = f (%) 139 (1,00D0) <0D001 NaN Stratified by trt 1 2 p test n 158 154 status (%) 0.894 0 83 (52.5) 85 (55.2) 1 10 ( 6.3) 9 ( 5.8) 2 65 (41.1) 60 (39.0) sex = f (%) 137 (86.7) 139 (90.3) 0.421 ascites = 1 (%) 14 ( 8.9) 10 ( 6.5) 0.567 hepato = 1 (%) 73 (46.2) 87 (56.5) 0.088 spiders = 1 (%) 45 (28.5) 45 (29.2) 0.985 edema (%) 0.877 0 132 (83.5) 131 (85.1) 0.5 16 (10.1) 13 ( 8.4) 1 10 ( 6.3) 10 ( 6.5) stage (%) 0.201 1 12 ( 7.6) 4 ( 2.6) 2 35 (22.2) 32 (20.8) 3 56 (35.4) 64 (41.6) 4 55 (34.8) 54 (35.1) Stratified by trt 1 2 p test n 158 154 status (%) 0.894 0 83 (52.5) 85 (55.2) 1 10 ( 6.3) 9 ( 5.8) 2 65 (41.1) 60 (39.0) sex = f (%) 137 (86.7) 139 (90.3) 0.421 ascites = 1 (%) 14 ( 8.9) 10 ( 6.5) 0.567 hepato = 1 (%) 73 (46.2) 87 (56.5) 0.088 spiders = 1 (%) 45 (28.5) 45 (29.2) 0.985 edema (%) 0.877 0 132 (83.5) 131 (85.1) 0.5 16 (10.1) 13 ( 8.4) 1 10 ( 6.3) 10 ( 6.5) stage (%) 0.201 1 12 ( 7.6) 4 ( 2.6) 2 35 (22.2) 32 (20.8) 3 56 (35.4) 64 (41.6) 4 55 (34.8) 54 (35.1) Overall n 418 status (%) 0 232 (55.5) 1 25 ( 6.0) 2 161 (38.5) sex = f (%) 374 (89.5) ascites = 1 (%) 24 ( 7.7) hepato = 1 (%) 160 (51.3) spiders = 1 (%) 90 (28.8) edema (%) 0 354 (84.7) 0.5 44 (10.5) 1 20 ( 4.8) stage (%) 1 21 ( 5.1) 2 92 (22.3) 3 155 (37.6) 4 144 (35.0) Overall n 418 status (%) 0 232 (55.5) 1 25 ( 6.0) 2 161 (38.5) sex = f (%) 374 (89.5) ascites = 1 (%) 24 ( 7.7) hepato = 1 (%) 160 (51.3) spiders = 1 (%) 90 (28.8) edema (%) 0 354 (84.7) 0.5 44 (10.5) 1 20 ( 4.8) stage (%) 1 21 ( 5.1) 2 92 (22.3) 3 155 (37.6) 4 144 (35.0) Overall n 418 status (%) 0 232 (55.5) 1 25 ( 6.0) 2 161 (38.5) sex = f (%) 374 (89.5) ascites (%) 0 288 (68.9) 1 24 ( 5.7) NA 106 (25.4) hepato (%) 0 152 (36.4) 1 160 (38.3) NA 106 (25.4) spiders (%) 0 222 (53.1) 1 90 (21.5) NA 106 (25.4) edema (%) 0 354 (84.7) 0.5 44 (10.5) 1 20 ( 4.8) stage (%) 1 21 ( 5.0) 2 92 (22.0) 3 155 (37.1) 4 144 (34.4) NA 6 ( 1.4) Overall n 418 status (%) 0 232 (55.5) 1 25 ( 6.0) 2 161 (38.5) sex = f (%) 374 (89.5) ascites (%) 0 288 (68.9) 1 24 ( 5.7) NA 106 (25.4) hepato (%) 0 152 (36.4) 1 160 (38.3) NA 106 (25.4) spiders (%) 0 222 (53.1) 1 90 (21.5) NA 106 (25.4) edema (%) 0 354 (84.7) 0.5 44 (10.5) 1 20 ( 4.8) stage (%) 1 21 ( 5.0) 2 92 (22.0) 3 155 (37.1) 4 144 (34.4) NA 6 ( 1.4) Stratified by trt:sex 1:m 2:m 1:f 2:f p test n 21 15 137 139 status (%) 0.033 0 4 (19.0) 7 (46.7) 79 ( 57.7) 78 ( 56.1) 1 3 (14.3) 0 ( 0.0) 7 ( 5.1) 9 ( 6.5) 2 14 (66.7) 8 (53.3) 51 ( 37.2) 52 ( 37.4) sex = f (%) 0 ( 0.0) 0 ( 0.0) 137 (100.0) 139 (100.0) <0.001 ascites = 1 (%) 1 ( 4.8) 2 (13.3) 13 ( 9.5) 8 ( 5.8) 0.516 hepato = 1 (%) 12 (57.1) 9 (60.0) 61 ( 44.5) 78 ( 56.1) 0.208 spiders = 1 (%) 3 (14.3) 1 ( 6.7) 42 ( 30.7) 44 ( 31.7) 0.089 edema (%) 0.906 0 17 (81.0) 12 (80.0) 115 ( 83.9) 119 ( 85.6) 0.5 3 (14.3) 1 ( 6.7) 13 ( 9.5) 12 ( 8.6) 1 1 ( 4.8) 2 (13.3) 9 ( 6.6) 8 ( 5.8) stage (%) 0.646 1 2 ( 9.5) 1 ( 6.7) 10 ( 7.3) 3 ( 2.2) 2 4 (19.0) 2 (13.3) 31 ( 22.6) 30 ( 21.6) 3 7 (33.3) 5 (33.3) 49 ( 35.8) 59 ( 42.4) 4 8 (38.1) 7 (46.7) 47 ( 34.3) 47 ( 33.8) Stratified by trt:sex 1:m 2:m 1:f 2:f p test n 21 15 137 139 status (%) 0.033 0 4 (19.0) 7 (46.7) 79 ( 57.7) 78 ( 56.1) 1 3 (14.3) 0 ( 0.0) 7 ( 5.1) 9 ( 6.5) 2 14 (66.7) 8 (53.3) 51 ( 37.2) 52 ( 37.4) sex = f (%) 0 ( 0.0) 0 ( 0.0) 137 (100.0) 139 (100.0) <0.001 ascites = 1 (%) 1 ( 4.8) 2 (13.3) 13 ( 9.5) 8 ( 5.8) 0.516 hepato = 1 (%) 12 (57.1) 9 (60.0) 61 ( 44.5) 78 ( 56.1) 0.208 spiders = 1 (%) 3 (14.3) 1 ( 6.7) 42 ( 30.7) 44 ( 31.7) 0.089 edema (%) 0.906 0 17 (81.0) 12 (80.0) 115 ( 83.9) 119 ( 85.6) 0.5 3 (14.3) 1 ( 6.7) 13 ( 9.5) 12 ( 8.6) 1 1 ( 4.8) 2 (13.3) 9 ( 6.6) 8 ( 5.8) stage (%) 0.646 1 2 ( 9.5) 1 ( 6.7) 10 ( 7.3) 3 ( 2.2) 2 4 (19.0) 2 (13.3) 31 ( 22.6) 30 ( 21.6) 3 7 (33.3) 5 (33.3) 49 ( 35.8) 59 ( 42.4) 4 8 (38.1) 7 (46.7) 47 ( 34.3) 47 ( 33.8) Stratified by trt:sex 1:m 2:m 1:f 2:f n 21 15 137 139 status (%) 0 4 (19.048) 7 (46.667) 79 ( 57.664) 78 ( 56.115) 1 3 (14.286) 0 ( 0.000) 7 ( 5.109) 9 ( 6.475) 2 14 (66.667) 8 (53.333) 51 ( 37.226) 52 ( 37.410) sex = f (%) 0 ( 0.000) 0 ( 0.000) 137 (100.000) 139 (100.000) ascites = 1 (%) 1 ( 4.762) 2 (13.333) 13 ( 9.489) 8 ( 5.755) hepato = 1 (%) 12 (57.143) 9 (60.000) 61 ( 44.526) 78 ( 56.115) spiders = 1 (%) 3 (14.286) 1 ( 6.667) 42 ( 30.657) 44 ( 31.655) edema (%) 0 17 (80.952) 12 (80.000) 115 ( 83.942) 119 ( 85.612) 0.5 3 (14.286) 1 ( 6.667) 13 ( 9.489) 12 ( 8.633) 1 1 ( 4.762) 2 (13.333) 9 ( 6.569) 8 ( 5.755) stage (%) 1 2 ( 9.524) 1 ( 6.667) 10 ( 7.299) 3 ( 2.158) 2 4 (19.048) 2 (13.333) 31 ( 22.628) 30 ( 21.583) 3 7 (33.333) 5 (33.333) 49 ( 35.766) 59 ( 42.446) 4 8 (38.095) 7 (46.667) 47 ( 34.307) 47 ( 33.813) Stratified by trt:sex p test n status (%) 0.03270 0 1 2 sex = f (%) <0.00001 ascites = 1 (%) 0.51569 hepato = 1 (%) 0.20806 spiders = 1 (%) 0.08899 edema (%) 0.90584 0 0.5 1 stage (%) 0.64630 1 2 3 4 Stratified by trt:sex 1:m 2:m 1:f 2:f n 21 15 137 139 status (%) 0 4 (19.048) 7 (46.667) 79 ( 57.664) 78 ( 56.115) 1 3 (14.286) 0 ( 0.000) 7 ( 5.109) 9 ( 6.475) 2 14 (66.667) 8 (53.333) 51 ( 37.226) 52 ( 37.410) sex = f (%) 0 ( 0.000) 0 ( 0.000) 137 (100.000) 139 (100.000) ascites = 1 (%) 1 ( 4.762) 2 (13.333) 13 ( 9.489) 8 ( 5.755) hepato = 1 (%) 12 (57.143) 9 (60.000) 61 ( 44.526) 78 ( 56.115) spiders = 1 (%) 3 (14.286) 1 ( 6.667) 42 ( 30.657) 44 ( 31.655) edema (%) 0 17 (80.952) 12 (80.000) 115 ( 83.942) 119 ( 85.612) 0.5 3 (14.286) 1 ( 6.667) 13 ( 9.489) 12 ( 8.633) 1 1 ( 4.762) 2 (13.333) 9 ( 6.569) 8 ( 5.755) stage (%) 1 2 ( 9.524) 1 ( 6.667) 10 ( 7.299) 3 ( 2.158) 2 4 (19.048) 2 (13.333) 31 ( 22.628) 30 ( 21.583) 3 7 (33.333) 5 (33.333) 49 ( 35.766) 59 ( 42.446) 4 8 (38.095) 7 (46.667) 47 ( 34.307) 47 ( 33.813) Stratified by trt:sex p test n status (%) 0.03270 0 1 2 sex = f (%) <0.00001 ascites = 1 (%) 0.51569 hepato = 1 (%) 0.20806 spiders = 1 (%) 0.08899 edema (%) 0.90584 0 0.5 1 stage (%) 0.64630 1 2 3 4 Stratified by trt:sex 1:m 2:m 1:f 2:f n 21 15 137 139 status (%) 0 4 (19.0) 7 (46.7) 79 ( 57.7) 78 ( 56.1) 1 3 (14.3) 0 ( 0.0) 7 ( 5.1) 9 ( 6.5) 2 14 (66.7) 8 (53.3) 51 ( 37.2) 52 ( 37.4) sex = f (%) 0 ( 0.0) 0 ( 0.0) 137 (100.0) 139 (100.0) ascites = 1 (%) 1 ( 4.8) 2 (13.3) 13 ( 9.5) 8 ( 5.8) hepato = 1 (%) 12 (57.1) 9 (60.0) 61 ( 44.5) 78 ( 56.1) spiders = 1 (%) 3 (14.3) 1 ( 6.7) 42 ( 30.7) 44 ( 31.7) edema (%) 0 17 (81.0) 12 (80.0) 115 ( 83.9) 119 ( 85.6) 0.5 3 (14.3) 1 ( 6.7) 13 ( 9.5) 12 ( 8.6) 1 1 ( 4.8) 2 (13.3) 9 ( 6.6) 8 ( 5.8) stage (%) 1 2 ( 9.5) 1 ( 6.7) 10 ( 7.3) 3 ( 2.2) 2 4 (19.0) 2 (13.3) 31 ( 22.6) 30 ( 21.6) 3 7 (33.3) 5 (33.3) 49 ( 35.8) 59 ( 42.4) 4 8 (38.1) 7 (46.7) 47 ( 34.3) 47 ( 33.8) Stratified by trt:sex 1:m 2:m 1:f 2:f n 21 15 137 139 status (%) 0 4 (19.0) 7 (46.7) 79 ( 57.7) 78 ( 56.1) 1 3 (14.3) 0 ( 0.0) 7 ( 5.1) 9 ( 6.5) 2 14 (66.7) 8 (53.3) 51 ( 37.2) 52 ( 37.4) sex = f (%) 0 ( 0.0) 0 ( 0.0) 137 (100.0) 139 (100.0) ascites = 1 (%) 1 ( 4.8) 2 (13.3) 13 ( 9.5) 8 ( 5.8) hepato = 1 (%) 12 (57.1) 9 (60.0) 61 ( 44.5) 78 ( 56.1) spiders = 1 (%) 3 (14.3) 1 ( 6.7) 42 ( 30.7) 44 ( 31.7) edema (%) 0 17 (81.0) 12 (80.0) 115 ( 83.9) 119 ( 85.6) 0.5 3 (14.3) 1 ( 6.7) 13 ( 9.5) 12 ( 8.6) 1 1 ( 4.8) 2 (13.3) 9 ( 6.6) 8 ( 5.8) stage (%) 1 2 ( 9.5) 1 ( 6.7) 10 ( 7.3) 3 ( 2.2) 2 4 (19.0) 2 (13.3) 31 ( 22.6) 30 ( 21.6) 3 7 (33.3) 5 (33.3) 49 ( 35.8) 59 ( 42.4) 4 8 (38.1) 7 (46.7) 47 ( 34.3) 47 ( 33.8) Stratified by trt 1 2 p test n 158 154 status (%) 0.894 0 83 (52.5) 85 (55.2) 1 10 (6.3) 9 (5.8) 2 65 (41.1) 60 (39.0) sex = f (%) 137 (86.7) 139 (90.3) 0.421 ascites = 1 (%) 14 (8.9) 10 (6.5) 0.567 hepato = 1 (%) 73 (46.2) 87 (56.5) 0.088 spiders = 1 (%) 45 (28.5) 45 (29.2) 0.985 edema (%) 0.877 0 132 (83.5) 131 (85.1) 0.5 16 (10.1) 13 (8.4) 1 10 (6.3) 10 (6.5) stage (%) 0.201 1 12 (7.6) 4 (2.6) 2 35 (22.2) 32 (20.8) 3 56 (35.4) 64 (41.6) 4 55 (34.8) 54 (35.1) Stratified by trt 1 2 p test n 158 154 status (%) 0.894 0 83 (52.5) 85 (55.2) 1 10 (6.3) 9 (5.8) 2 65 (41.1) 60 (39.0) sex = f (%) 137 (86.7) 139 (90.3) 0.421 ascites = 1 (%) 14 (8.9) 10 (6.5) 0.567 hepato = 1 (%) 73 (46.2) 87 (56.5) 0.088 spiders = 1 (%) 45 (28.5) 45 (29.2) 0.985 edema (%) 0.877 0 132 (83.5) 131 (85.1) 0.5 16 (10.1) 13 (8.4) 1 10 (6.3) 10 (6.5) stage (%) 0.201 1 12 (7.6) 4 (2.6) 2 35 (22.2) 32 (20.8) 3 56 (35.4) 64 (41.6) 4 55 (34.8) 54 (35.1) Stratified by trt level 1 2 p test n 158 154 status (%) 0 83 (52.5) 85 (55.2) 0.894 1 10 ( 6.3) 9 ( 5.8) 2 65 (41.1) 60 (39.0) sex (%) m 21 (13.3) 15 ( 9.7) 0.421 f 137 (86.7) 139 (90.3) ascites (%) 0 144 (91.1) 144 (93.5) 0.567 1 14 ( 8.9) 10 ( 6.5) hepato (%) 0 85 (53.8) 67 (43.5) 0.088 1 73 (46.2) 87 (56.5) spiders (%) 0 113 (71.5) 109 (70.8) 0.985 1 45 (28.5) 45 (29.2) edema (%) 0 132 (83.5) 131 (85.1) 0.877 0.5 16 (10.1) 13 ( 8.4) 1 10 ( 6.3) 10 ( 6.5) stage (%) 1 12 ( 7.6) 4 ( 2.6) 0.201 2 35 (22.2) 32 (20.8) 3 56 (35.4) 64 (41.6) 4 55 (34.8) 54 (35.1) Stratified by trt level 1 2 p test n 158 154 status (%) 0 83 (52.5) 85 (55.2) 0.894 1 10 ( 6.3) 9 ( 5.8) 2 65 (41.1) 60 (39.0) sex (%) m 21 (13.3) 15 ( 9.7) 0.421 f 137 (86.7) 139 (90.3) ascites (%) 0 144 (91.1) 144 (93.5) 0.567 1 14 ( 8.9) 10 ( 6.5) hepato (%) 0 85 (53.8) 67 (43.5) 0.088 1 73 (46.2) 87 (56.5) spiders (%) 0 113 (71.5) 109 (70.8) 0.985 1 45 (28.5) 45 (29.2) edema (%) 0 132 (83.5) 131 (85.1) 0.877 0.5 16 (10.1) 13 ( 8.4) 1 10 ( 6.3) 10 ( 6.5) stage (%) 1 12 ( 7.6) 4 ( 2.6) 0.201 2 35 (22.2) 32 (20.8) 3 56 (35.4) 64 (41.6) 4 55 (34.8) 54 (35.1) Stratified by trt 1 2 p test n 158 154 status 0.894 0 83 (52.5) 85 (55.2) 1 10 ( 6.3) 9 ( 5.8) 2 65 (41.1) 60 (39.0) sex = f 137 (86.7) 139 (90.3) 0.421 ascites = 1 14 ( 8.9) 10 ( 6.5) 0.567 hepato = 1 73 (46.2) 87 (56.5) 0.088 spiders = 1 45 (28.5) 45 (29.2) 0.985 edema 0.877 0 132 (83.5) 131 (85.1) 0.5 16 (10.1) 13 ( 8.4) 1 10 ( 6.3) 10 ( 6.5) stage 0.201 1 12 ( 7.6) 4 ( 2.6) 2 35 (22.2) 32 (20.8) 3 56 (35.4) 64 (41.6) 4 55 (34.8) 54 (35.1) Stratified by trt 1 2 p test n 158 154 status 0.894 0 83 (52.5) 85 (55.2) 1 10 ( 6.3) 9 ( 5.8) 2 65 (41.1) 60 (39.0) sex = f 137 (86.7) 139 (90.3) 0.421 ascites = 1 14 ( 8.9) 10 ( 6.5) 0.567 hepato = 1 73 (46.2) 87 (56.5) 0.088 spiders = 1 45 (28.5) 45 (29.2) 0.985 edema 0.877 0 132 (83.5) 131 (85.1) 0.5 16 (10.1) 13 ( 8.4) 1 10 ( 6.3) 10 ( 6.5) stage 0.201 1 12 ( 7.6) 4 ( 2.6) 2 35 (22.2) 32 (20.8) 3 56 (35.4) 64 (41.6) 4 55 (34.8) 54 (35.1) Stratified by trt 1 2 p test n 158 154 status 0.894 0 83 85 1 10 9 2 65 60 sex = f 137 139 0.421 ascites = 1 14 10 0.567 hepato = 1 73 87 0.088 spiders = 1 45 45 0.985 edema 0.877 0 132 131 0.5 16 13 1 10 10 stage 0.201 1 12 4 2 35 32 3 56 64 4 55 54 Stratified by trt 1 2 p test n 158 154 status 0.894 0 83 85 1 10 9 2 65 60 sex = f 137 139 0.421 ascites = 1 14 10 0.567 hepato = 1 73 87 0.088 spiders = 1 45 45 0.985 edema 0.877 0 132 131 0.5 16 13 1 10 10 stage 0.201 1 12 4 2 35 32 3 56 64 4 55 54 Stratified by trt 1 2 p test n 158 154 status (%) 0.894 0 52.5 55.2 1 6.3 5.8 2 41.1 39.0 sex = f (%) 86.7 90.3 0.421 ascites = 1 (%) 8.9 6.5 0.567 hepato = 1 (%) 46.2 56.5 0.088 spiders = 1 (%) 28.5 29.2 0.985 edema (%) 0.877 0 83.5 85.1 0.5 10.1 8.4 1 6.3 6.5 stage (%) 0.201 1 7.6 2.6 2 22.2 20.8 3 35.4 41.6 4 34.8 35.1 Stratified by trt 1 2 p test n 158 154 status (%) 0.894 0 52.5 55.2 1 6.3 5.8 2 41.1 39.0 sex = f (%) 86.7 90.3 0.421 ascites = 1 (%) 8.9 6.5 0.567 hepato = 1 (%) 46.2 56.5 0.088 spiders = 1 (%) 28.5 29.2 0.985 edema (%) 0.877 0 83.5 85.1 0.5 10.1 8.4 1 6.3 6.5 stage (%) 0.201 1 7.6 2.6 2 22.2 20.8 3 35.4 41.6 4 34.8 35.1 Stratified by trt 1 2 p test n 158 154 status % (freq) 0.894 0 52.5 ( 83) 55.2 ( 85) 1 6.3 ( 10) 5.8 ( 9) 2 41.1 ( 65) 39.0 ( 60) sex = f % (freq) 86.7 (137) 90.3 (139) 0.421 ascites = 1 % (freq) 8.9 ( 14) 6.5 ( 10) 0.567 hepato = 1 % (freq) 46.2 ( 73) 56.5 ( 87) 0.088 spiders = 1 % (freq) 28.5 ( 45) 29.2 ( 45) 0.985 edema % (freq) 0.877 0 83.5 (132) 85.1 (131) 0.5 10.1 ( 16) 8.4 ( 13) 1 6.3 ( 10) 6.5 ( 10) stage % (freq) 0.201 1 7.6 ( 12) 2.6 ( 4) 2 22.2 ( 35) 20.8 ( 32) 3 35.4 ( 56) 41.6 ( 64) 4 34.8 ( 55) 35.1 ( 54) Stratified by trt 1 2 p test n 158 154 status % (freq) 0.894 0 52.5 ( 83) 55.2 ( 85) 1 6.3 ( 10) 5.8 ( 9) 2 41.1 ( 65) 39.0 ( 60) sex = f % (freq) 86.7 (137) 90.3 (139) 0.421 ascites = 1 % (freq) 8.9 ( 14) 6.5 ( 10) 0.567 hepato = 1 % (freq) 46.2 ( 73) 56.5 ( 87) 0.088 spiders = 1 % (freq) 28.5 ( 45) 29.2 ( 45) 0.985 edema % (freq) 0.877 0 83.5 (132) 85.1 (131) 0.5 10.1 ( 16) 8.4 ( 13) 1 6.3 ( 10) 6.5 ( 10) stage % (freq) 0.201 1 7.6 ( 12) 2.6 ( 4) 2 22.2 ( 35) 20.8 ( 32) 3 35.4 ( 56) 41.6 ( 64) 4 34.8 ( 55) 35.1 ( 54) Stratified by trt 1 2 p test n 158 154 status (%) 0.894 0 83 (52.5) 85 (55.2) 1 10 ( 6.3) 9 ( 5.8) 2 65 (41.1) 60 (39.0) sex = m/f (%) 21/137 (13.3/86.7) 15/139 (9.7/90.3) 0.421 ascites = 1 (%) 14 ( 8.9) 10 ( 6.5) 0.567 hepato = 1 (%) 73 (46.2) 87 (56.5) 0.088 spiders = 1 (%) 45 (28.5) 45 (29.2) 0.985 edema (%) 0.877 0 132 (83.5) 131 (85.1) 0.5 16 (10.1) 13 ( 8.4) 1 10 ( 6.3) 10 ( 6.5) stage (%) 0.201 1 12 ( 7.6) 4 ( 2.6) 2 35 (22.2) 32 (20.8) 3 56 (35.4) 64 (41.6) 4 55 (34.8) 54 (35.1) Stratified by trt 1 2 p test n 158 154 status (%) 0.894 0 83 (52.5) 85 (55.2) 1 10 ( 6.3) 9 ( 5.8) 2 65 (41.1) 60 (39.0) sex = m/f (%) 21/137 (13.3/86.7) 15/139 (9.7/90.3) 0.421 ascites = 1 (%) 14 ( 8.9) 10 ( 6.5) 0.567 hepato = 1 (%) 73 (46.2) 87 (56.5) 0.088 spiders = 1 (%) 45 (28.5) 45 (29.2) 0.985 edema (%) 0.877 0 132 (83.5) 131 (85.1) 0.5 16 (10.1) 13 ( 8.4) 1 10 ( 6.3) 10 ( 6.5) stage (%) 0.201 1 12 ( 7.6) 4 ( 2.6) 2 35 (22.2) 32 (20.8) 3 56 (35.4) 64 (41.6) 4 55 (34.8) 54 (35.1) "Stratified by trt" "" "level" "1" "2" "p" "test" "n" "" "158" "154" "" "" "status (%)" "0" "83 (52.5)" "85 (55.2)" "0.894" "" "" "1" "10 (6.3)" "9 (5.8)" "" "" "" "2" "65 (41.1)" "60 (39.0)" "" "" "sex (%)" "m" "21 (13.3)" "15 (9.7)" "0.421" "" "" "f" "137 (86.7)" "139 (90.3)" "" "" "ascites (%)" "0" "144 (91.1)" "144 (93.5)" "0.567" "" "" "1" "14 (8.9)" "10 (6.5)" "" "" "hepato (%)" "0" "85 (53.8)" "67 (43.5)" "0.088" "" "" "1" "73 (46.2)" "87 (56.5)" "" "" "spiders (%)" "0" "113 (71.5)" "109 (70.8)" "0.985" "" "" "1" "45 (28.5)" "45 (29.2)" "" "" "edema (%)" "0" "132 (83.5)" "131 (85.1)" "0.877" "" "" "0.5" "16 (10.1)" "13 (8.4)" "" "" "" "1" "10 (6.3)" "10 (6.5)" "" "" "stage (%)" "1" "12 (7.6)" "4 (2.6)" "0.201" "" "" "2" "35 (22.2)" "32 (20.8)" "" "" "" "3" "56 (35.4)" "64 (41.6)" "" "" "" "4" "55 (34.8)" "54 (35.1)" "" "" "Stratified by trt" "" "level" "1" "2" "p" "test" "n" "" "158" "154" "" "" "status (%)" "0" "83 (52.5)" "85 (55.2)" "0.894" "" "" "1" "10 (6.3)" "9 (5.8)" "" "" "" "2" "65 (41.1)" "60 (39.0)" "" "" "sex (%)" "m" "21 (13.3)" "15 (9.7)" "0.421" "" "" "f" "137 (86.7)" "139 (90.3)" "" "" "ascites (%)" "0" "144 (91.1)" "144 (93.5)" "0.567" "" "" "1" "14 (8.9)" "10 (6.5)" "" "" "hepato (%)" "0" "85 (53.8)" "67 (43.5)" "0.088" "" "" "1" "73 (46.2)" "87 (56.5)" "" "" "spiders (%)" "0" "113 (71.5)" "109 (70.8)" "0.985" "" "" "1" "45 (28.5)" "45 (29.2)" "" "" "edema (%)" "0" "132 (83.5)" "131 (85.1)" "0.877" "" "" "0.5" "16 (10.1)" "13 (8.4)" "" "" "" "1" "10 (6.3)" "10 (6.5)" "" "" "stage (%)" "1" "12 (7.6)" "4 (2.6)" "0.201" "" "" "2" "35 (22.2)" "32 (20.8)" "" "" "" "3" "56 (35.4)" "64 (41.6)" "" "" "" "4" "55 (34.8)" "54 (35.1)" "" "" "Stratified by trt" "" "level" "Overall" "1" "2" "p" "test" "n" "" "418" "158" "154" "" "" "status (%)" "0" "232 (55.5)" "83 (52.5)" "85 (55.2)" "0.894" "" "" "1" "25 (6.0)" "10 (6.3)" "9 (5.8)" "" "" "" "2" "161 (38.5)" "65 (41.1)" "60 (39.0)" "" "" "sex (%)" "m" "44 (10.5)" "21 (13.3)" "15 (9.7)" "0.421" "" "" "f" "374 (89.5)" "137 (86.7)" "139 (90.3)" "" "" "ascites (%)" "0" "288 (92.3)" "144 (91.1)" "144 (93.5)" "0.567" "" "" "1" "24 (7.7)" "14 (8.9)" "10 (6.5)" "" "" "hepato (%)" "0" "152 (48.7)" "85 (53.8)" "67 (43.5)" "0.088" "" "" "1" "160 (51.3)" "73 (46.2)" "87 (56.5)" "" "" "spiders (%)" "0" "222 (71.2)" "113 (71.5)" "109 (70.8)" "0.985" "" "" "1" "90 (28.8)" "45 (28.5)" "45 (29.2)" "" "" "edema (%)" "0" "354 (84.7)" "132 (83.5)" "131 (85.1)" "0.877" "" "" "0.5" "44 (10.5)" "16 (10.1)" "13 (8.4)" "" "" "" "1" "20 (4.8)" "10 (6.3)" "10 (6.5)" "" "" "stage (%)" "1" "21 (5.1)" "12 (7.6)" "4 (2.6)" "0.201" "" "" "2" "92 (22.3)" "35 (22.2)" "32 (20.8)" "" "" "" "3" "155 (37.6)" "56 (35.4)" "64 (41.6)" "" "" "" "4" "144 (35.0)" "55 (34.8)" "54 (35.1)" "" "" "Stratified by trt" "" "level" "Overall" "1" "2" "p" "test" "n" "" "418" "158" "154" "" "" "status (%)" "0" "232 (55.5)" "83 (52.5)" "85 (55.2)" "0.894" "" "" "1" "25 (6.0)" "10 (6.3)" "9 (5.8)" "" "" "" "2" "161 (38.5)" "65 (41.1)" "60 (39.0)" "" "" "sex (%)" "m" "44 (10.5)" "21 (13.3)" "15 (9.7)" "0.421" "" "" "f" "374 (89.5)" "137 (86.7)" "139 (90.3)" "" "" "ascites (%)" "0" "288 (92.3)" "144 (91.1)" "144 (93.5)" "0.567" "" "" "1" "24 (7.7)" "14 (8.9)" "10 (6.5)" "" "" "hepato (%)" "0" "152 (48.7)" "85 (53.8)" "67 (43.5)" "0.088" "" "" "1" "160 (51.3)" "73 (46.2)" "87 (56.5)" "" "" "spiders (%)" "0" "222 (71.2)" "113 (71.5)" "109 (70.8)" "0.985" "" "" "1" "90 (28.8)" "45 (28.5)" "45 (29.2)" "" "" "edema (%)" "0" "354 (84.7)" "132 (83.5)" "131 (85.1)" "0.877" "" "" "0.5" "44 (10.5)" "16 (10.1)" "13 (8.4)" "" "" "" "1" "20 (4.8)" "10 (6.3)" "10 (6.5)" "" "" "stage (%)" "1" "21 (5.1)" "12 (7.6)" "4 (2.6)" "0.201" "" "" "2" "92 (22.3)" "35 (22.2)" "32 (20.8)" "" "" "" "3" "155 (37.6)" "56 (35.4)" "64 (41.6)" "" "" "" "4" "144 (35.0)" "55 (34.8)" "54 (35.1)" "" "" Stratified by trt:sex Overall 1:m 2:m 1:f 2:f n 418 21 15 137 139 status (%) 0 232 (55.5) 4 (19.0) 7 (46.7) 79 ( 57.7) 78 ( 56.1) 1 25 ( 6.0) 3 (14.3) 0 ( 0.0) 7 ( 5.1) 9 ( 6.5) 2 161 (38.5) 14 (66.7) 8 (53.3) 51 ( 37.2) 52 ( 37.4) sex = f (%) 374 (89.5) 0 ( 0.0) 0 ( 0.0) 137 (100.0) 139 (100.0) ascites = 1 (%) 24 ( 7.7) 1 ( 4.8) 2 (13.3) 13 ( 9.5) 8 ( 5.8) hepato = 1 (%) 160 (51.3) 12 (57.1) 9 (60.0) 61 ( 44.5) 78 ( 56.1) spiders = 1 (%) 90 (28.8) 3 (14.3) 1 ( 6.7) 42 ( 30.7) 44 ( 31.7) edema (%) 0 354 (84.7) 17 (81.0) 12 (80.0) 115 ( 83.9) 119 ( 85.6) 0.5 44 (10.5) 3 (14.3) 1 ( 6.7) 13 ( 9.5) 12 ( 8.6) 1 20 ( 4.8) 1 ( 4.8) 2 (13.3) 9 ( 6.6) 8 ( 5.8) stage (%) 1 21 ( 5.1) 2 ( 9.5) 1 ( 6.7) 10 ( 7.3) 3 ( 2.2) 2 92 (22.3) 4 (19.0) 2 (13.3) 31 ( 22.6) 30 ( 21.6) 3 155 (37.6) 7 (33.3) 5 (33.3) 49 ( 35.8) 59 ( 42.4) 4 144 (35.0) 8 (38.1) 7 (46.7) 47 ( 34.3) 47 ( 33.8) Stratified by trt:sex p test n status (%) 0.033 0 1 2 sex = f (%) <0.001 ascites = 1 (%) 0.516 hepato = 1 (%) 0.208 spiders = 1 (%) 0.089 edema (%) 0.906 0 0.5 1 stage (%) 0.646 1 2 3 4 Stratified by trt:sex Overall 1:m 2:m 1:f 2:f n 418 21 15 137 139 status (%) 0 232 (55.5) 4 (19.0) 7 (46.7) 79 ( 57.7) 78 ( 56.1) 1 25 ( 6.0) 3 (14.3) 0 ( 0.0) 7 ( 5.1) 9 ( 6.5) 2 161 (38.5) 14 (66.7) 8 (53.3) 51 ( 37.2) 52 ( 37.4) sex = f (%) 374 (89.5) 0 ( 0.0) 0 ( 0.0) 137 (100.0) 139 (100.0) ascites = 1 (%) 24 ( 7.7) 1 ( 4.8) 2 (13.3) 13 ( 9.5) 8 ( 5.8) hepato = 1 (%) 160 (51.3) 12 (57.1) 9 (60.0) 61 ( 44.5) 78 ( 56.1) spiders = 1 (%) 90 (28.8) 3 (14.3) 1 ( 6.7) 42 ( 30.7) 44 ( 31.7) edema (%) 0 354 (84.7) 17 (81.0) 12 (80.0) 115 ( 83.9) 119 ( 85.6) 0.5 44 (10.5) 3 (14.3) 1 ( 6.7) 13 ( 9.5) 12 ( 8.6) 1 20 ( 4.8) 1 ( 4.8) 2 (13.3) 9 ( 6.6) 8 ( 5.8) stage (%) 1 21 ( 5.1) 2 ( 9.5) 1 ( 6.7) 10 ( 7.3) 3 ( 2.2) 2 92 (22.3) 4 (19.0) 2 (13.3) 31 ( 22.6) 30 ( 21.6) 3 155 (37.6) 7 (33.3) 5 (33.3) 49 ( 35.8) 59 ( 42.4) 4 144 (35.0) 8 (38.1) 7 (46.7) 47 ( 34.3) 47 ( 33.8) Stratified by trt:sex p test n status (%) 0.033 0 1 2 sex = f (%) <0.001 ascites = 1 (%) 0.516 hepato = 1 (%) 0.208 spiders = 1 (%) 0.089 edema (%) 0.906 0 0.5 1 stage (%) 0.646 1 2 3 4 Stratified by trt 1 2 p test n 158 154 status (%) 0.894 0 83 (52.5) 85 (55.2) 1 10 ( 6.3) 9 ( 5.8) 2 65 (41.1) 60 (39.0) sex = f (%) 137 (86.7) 139 (90.3) 0.421 ascites = 1 (%) 14 ( 8.9) 10 ( 6.5) 0.567 hepato = 1 (%) 73 (46.2) 87 (56.5) 0.088 spiders = 1 (%) 45 (28.5) 45 (29.2) 0.985 edema (%) 0.877 0 132 (83.5) 131 (85.1) 0.5 16 (10.1) 13 ( 8.4) 1 10 ( 6.3) 10 ( 6.5) stage (%) 0.201 1 12 ( 7.6) 4 ( 2.6) 2 35 (22.2) 32 (20.8) 3 56 (35.4) 64 (41.6) 4 55 (34.8) 54 (35.1) Cell Contents |-------------------------| | N | | Chi-square contribution | | N / Row Total | | N / Col Total | | N / Table Total | |-------------------------| Total Observations in Table: 312 | trt status | 1 | 2 | Row Total | -------------|-----------|-----------|-----------| 0 | 83 | 85 | 168 | | 0.051 | 0.052 | | | 0.494 | 0.506 | 0.538 | | 0.525 | 0.552 | | | 0.266 | 0.272 | | -------------|-----------|-----------|-----------| 1 | 10 | 9 | 19 | | 0.015 | 0.015 | | | 0.526 | 0.474 | 0.061 | | 0.063 | 0.058 | | | 0.032 | 0.029 | | -------------|-----------|-----------|-----------| 2 | 65 | 60 | 125 | | 0.046 | 0.047 | | | 0.520 | 0.480 | 0.401 | | 0.411 | 0.390 | | | 0.208 | 0.192 | | -------------|-----------|-----------|-----------| Column Total | 158 | 154 | 312 | | 0.506 | 0.494 | | -------------|-----------|-----------|-----------| Cell Contents |-------------------------| | N | | Chi-square contribution | | N / Row Total | | N / Col Total | | N / Table Total | |-------------------------| Total Observations in Table: 312 | trt sex | 1 | 2 | Row Total | -------------|-----------|-----------|-----------| m | 21 | 15 | 36 | | 0.421 | 0.432 | | | 0.583 | 0.417 | 0.115 | | 0.133 | 0.097 | | | 0.067 | 0.048 | | -------------|-----------|-----------|-----------| f | 137 | 139 | 276 | | 0.055 | 0.056 | | | 0.496 | 0.504 | 0.885 | | 0.867 | 0.903 | | | 0.439 | 0.446 | | -------------|-----------|-----------|-----------| Column Total | 158 | 154 | 312 | | 0.506 | 0.494 | | -------------|-----------|-----------|-----------| Cell Contents |-------------------------| | N | | Chi-square contribution | | N / Row Total | | N / Col Total | | N / Table Total | |-------------------------| Total Observations in Table: 312 | trt ascites | 1 | 2 | Row Total | -------------|-----------|-----------|-----------| 0 | 144 | 144 | 288 | | 0.023 | 0.024 | | | 0.500 | 0.500 | 0.923 | | 0.911 | 0.935 | | | 0.462 | 0.462 | | -------------|-----------|-----------|-----------| 1 | 14 | 10 | 24 | | 0.280 | 0.288 | | | 0.583 | 0.417 | 0.077 | | 0.089 | 0.065 | | | 0.045 | 0.032 | | -------------|-----------|-----------|-----------| Column Total | 158 | 154 | 312 | | 0.506 | 0.494 | | -------------|-----------|-----------|-----------| Cell Contents |-------------------------| | N | | Chi-square contribution | | N / Row Total | | N / Col Total | | N / Table Total | |-------------------------| Total Observations in Table: 312 | trt hepato | 1 | 2 | Row Total | -------------|-----------|-----------|-----------| 0 | 85 | 67 | 152 | | 0.837 | 0.859 | | | 0.559 | 0.441 | 0.487 | | 0.538 | 0.435 | | | 0.272 | 0.215 | | -------------|-----------|-----------|-----------| 1 | 73 | 87 | 160 | | 0.795 | 0.816 | | | 0.456 | 0.544 | 0.513 | | 0.462 | 0.565 | | | 0.234 | 0.279 | | -------------|-----------|-----------|-----------| Column Total | 158 | 154 | 312 | | 0.506 | 0.494 | | -------------|-----------|-----------|-----------| Cell Contents |-------------------------| | N | | Chi-square contribution | | N / Row Total | | N / Col Total | | N / Table Total | |-------------------------| Total Observations in Table: 312 | trt spiders | 1 | 2 | Row Total | -------------|-----------|-----------|-----------| 0 | 113 | 109 | 222 | | 0.003 | 0.003 | | | 0.509 | 0.491 | 0.712 | | 0.715 | 0.708 | | | 0.362 | 0.349 | | -------------|-----------|-----------|-----------| 1 | 45 | 45 | 90 | | 0.007 | 0.007 | | | 0.500 | 0.500 | 0.288 | | 0.285 | 0.292 | | | 0.144 | 0.144 | | -------------|-----------|-----------|-----------| Column Total | 158 | 154 | 312 | | 0.506 | 0.494 | | -------------|-----------|-----------|-----------| Cell Contents |-------------------------| | N | | Chi-square contribution | | N / Row Total | | N / Col Total | | N / Table Total | |-------------------------| Total Observations in Table: 312 | trt edema | 1 | 2 | Row Total | -------------|-----------|-----------|-----------| 0 | 132 | 131 | 263 | | 0.011 | 0.011 | | | 0.502 | 0.498 | 0.843 | | 0.835 | 0.851 | | | 0.423 | 0.420 | | -------------|-----------|-----------|-----------| 0.5 | 16 | 13 | 29 | | 0.118 | 0.121 | | | 0.552 | 0.448 | 0.093 | | 0.101 | 0.084 | | | 0.051 | 0.042 | | -------------|-----------|-----------|-----------| 1 | 10 | 10 | 20 | | 0.002 | 0.002 | | | 0.500 | 0.500 | 0.064 | | 0.063 | 0.065 | | | 0.032 | 0.032 | | -------------|-----------|-----------|-----------| Column Total | 158 | 154 | 312 | | 0.506 | 0.494 | | -------------|-----------|-----------|-----------| Cell Contents |-------------------------| | N | | Chi-square contribution | | N / Row Total | | N / Col Total | | N / Table Total | |-------------------------| Total Observations in Table: 312 | trt stage | 1 | 2 | Row Total | -------------|-----------|-----------|-----------| 1 | 12 | 4 | 16 | | 1.875 | 1.923 | | | 0.750 | 0.250 | 0.051 | | 0.076 | 0.026 | | | 0.038 | 0.013 | | -------------|-----------|-----------|-----------| 2 | 35 | 32 | 67 | | 0.034 | 0.035 | | | 0.522 | 0.478 | 0.215 | | 0.222 | 0.208 | | | 0.112 | 0.103 | | -------------|-----------|-----------|-----------| 3 | 56 | 64 | 120 | | 0.374 | 0.384 | | | 0.467 | 0.533 | 0.385 | | 0.354 | 0.416 | | | 0.179 | 0.205 | | -------------|-----------|-----------|-----------| 4 | 55 | 54 | 109 | | 0.001 | 0.001 | | | 0.505 | 0.495 | 0.349 | | 0.348 | 0.351 | | | 0.176 | 0.173 | | -------------|-----------|-----------|-----------| Column Total | 158 | 154 | 312 | | 0.506 | 0.494 | | -------------|-----------|-----------|-----------| Stratified by trt 1 2 p test n 158 154 time (mean (SD)) 2015.62 (1094.12) 1996.86 (1155.93) 0.883 age (mean (SD)) 51.42 (11.01) 48.58 (9.96) 0.018 bili (mean (SD)) 2.87 (3.63) 3.65 (5.28) 0.131 chol (mean (SD)) 365.01 (209.54) 373.88 (252.48) 0.748 albumin (mean (SD)) 3.52 (0.44) 3.52 (0.40) 0.874 copper (mean (SD)) 97.64 (90.59) 97.65 (80.49) 0.999 alk.phos (mean (SD)) 2021.30 (2183.44) 1943.01 (2101.69) 0.747 ast (mean (SD)) 120.21 (54.52) 124.97 (58.93) 0.460 trig (mean (SD)) 124.14 (71.54) 125.25 (58.52) 0.886 platelet (mean (SD)) 258.75 (100.32) 265.20 (90.73) 0.555 protime (mean (SD)) 10.65 (0.85) 10.80 (1.14) 0.197 Stratified by trt 1 2 p test n 158 154 time (mean (SD)) 2015.62 (1094.12) 1996.86 (1155.93) 0.883 age (mean (SD)) 51.42 (11.01) 48.58 (9.96) 0.018 bili (mean (SD)) 2.87 (3.63) 3.65 (5.28) 0.131 chol (mean (SD)) 365.01 (209.54) 373.88 (252.48) 0.748 albumin (mean (SD)) 3.52 (0.44) 3.52 (0.40) 0.874 copper (mean (SD)) 97.64 (90.59) 97.65 (80.49) 0.999 alk.phos (mean (SD)) 2021.30 (2183.44) 1943.01 (2101.69) 0.747 ast (mean (SD)) 120.21 (54.52) 124.97 (58.93) 0.460 trig (mean (SD)) 124.14 (71.54) 125.25 (58.52) 0.886 platelet (mean (SD)) 258.75 (100.32) 265.20 (90.73) 0.555 protime (mean (SD)) 10.65 (0.85) 10.80 (1.14) 0.197 Overall n 418 time (mean (SD)) 1917.78 (1104.67) age (mean (SD)) 50.74 (10.45) bili (mean (SD)) 3.22 (4.41) chol (mean (SD)) 369.51 (231.94) albumin (mean (SD)) 3.50 (0.42) copper (mean (SD)) 97.65 (85.61) alk.phos (mean (SD)) 1982.66 (2140.39) ast (mean (SD)) 122.56 (56.70) trig (mean (SD)) 124.70 (65.15) platelet (mean (SD)) 257.02 (98.33) protime (mean (SD)) 10.73 (1.02) Overall n 418 time (mean (SD)) 1917.78 (1104.67) age (mean (SD)) 50.74 (10.45) bili (mean (SD)) 3.22 (4.41) chol (mean (SD)) 369.51 (231.94) albumin (mean (SD)) 3.50 (0.42) copper (mean (SD)) 97.65 (85.61) alk.phos (mean (SD)) 1982.66 (2140.39) ast (mean (SD)) 122.56 (56.70) trig (mean (SD)) 124.70 (65.15) platelet (mean (SD)) 257.02 (98.33) protime (mean (SD)) 10.73 (1.02) Stratified by trt:sex 1:m 2:m 1:f n 21 15 137 time (mean (SD)) 1793.48 (1244.70) 2156.33 (1428.56) 2049.67 (1070.20) age (mean (SD)) 55.57 (12.61) 57.09 (10.07) 50.78 (10.65) bili (mean (SD)) 2.98 (2.11) 2.72 (2.46) 2.86 (3.81) chol (mean (SD)) 403.43 (204.95) 301.00 (111.32) 358.24 (210.46) albumin (mean (SD)) 3.63 (0.43) 3.50 (0.49) 3.50 (0.44) copper (mean (SD)) 174.90 (105.33) 125.40 (89.18) 85.71 (82.27) alk.phos (mean (SD)) 2486.16 (2385.32) 1734.45 (2478.07) 1950.04 (2151.35) ast (mean (SD)) 128.71 (48.74) 112.58 (44.38) 118.91 (55.40) trig (mean (SD)) 145.81 (56.62) 114.86 (39.59) 120.28 (73.41) platelet (mean (SD)) 232.65 (97.38) 240.13 (73.93) 262.59 (100.53) protime (mean (SD)) 10.84 (0.94) 11.23 (0.97) 10.62 (0.84) Stratified by trt:sex 2:f p test n 139 time (mean (SD)) 1979.65 (1127.52) 0.730 age (mean (SD)) 47.66 (9.54) <0.001 bili (mean (SD)) 3.75 (5.50) 0.394 chol (mean (SD)) 381.73 (262.26) 0.512 albumin (mean (SD)) 3.53 (0.39) 0.585 copper (mean (SD)) 94.64 (79.25) <0.001 alk.phos (mean (SD)) 1965.52 (2066.15) 0.706 ast (mean (SD)) 126.30 (60.27) 0.598 trig (mean (SD)) 126.38 (60.22) 0.370 platelet (mean (SD)) 267.95 (92.20) 0.362 protime (mean (SD)) 10.75 (1.15) 0.137 Stratified by trt:sex 1:m 2:m 1:f n 21 15 137 time (mean (SD)) 1793.48 (1244.70) 2156.33 (1428.56) 2049.67 (1070.20) age (mean (SD)) 55.57 (12.61) 57.09 (10.07) 50.78 (10.65) bili (mean (SD)) 2.98 (2.11) 2.72 (2.46) 2.86 (3.81) chol (mean (SD)) 403.43 (204.95) 301.00 (111.32) 358.24 (210.46) albumin (mean (SD)) 3.63 (0.43) 3.50 (0.49) 3.50 (0.44) copper (mean (SD)) 174.90 (105.33) 125.40 (89.18) 85.71 (82.27) alk.phos (mean (SD)) 2486.16 (2385.32) 1734.45 (2478.07) 1950.04 (2151.35) ast (mean (SD)) 128.71 (48.74) 112.58 (44.38) 118.91 (55.40) trig (mean (SD)) 145.81 (56.62) 114.86 (39.59) 120.28 (73.41) platelet (mean (SD)) 232.65 (97.38) 240.13 (73.93) 262.59 (100.53) protime (mean (SD)) 10.84 (0.94) 11.23 (0.97) 10.62 (0.84) Stratified by trt:sex 2:f p test n 139 time (mean (SD)) 1979.65 (1127.52) 0.730 age (mean (SD)) 47.66 (9.54) <0.001 bili (mean (SD)) 3.75 (5.50) 0.394 chol (mean (SD)) 381.73 (262.26) 0.512 albumin (mean (SD)) 3.53 (0.39) 0.585 copper (mean (SD)) 94.64 (79.25) <0.001 alk.phos (mean (SD)) 1965.52 (2066.15) 0.706 ast (mean (SD)) 126.30 (60.27) 0.598 trig (mean (SD)) 126.38 (60.22) 0.370 platelet (mean (SD)) 267.95 (92.20) 0.362 protime (mean (SD)) 10.75 (1.15) 0.137 Stratified by trt 1 2 p test n 158 154 time (mean (SD)) 2015.620 (1094.123) 1996.864 (1155.929) 0.88305 age (mean (SD)) 51.419 (11.007) 48.583 (9.958) 0.01767 bili (mean (SD)) 2.873 (3.629) 3.649 (5.282) 0.13094 chol (mean (SD)) 365.014 (209.544) 373.882 (252.485) 0.74799 albumin (mean (SD)) 3.516 (0.443) 3.524 (0.396) 0.87388 copper (mean (SD)) 97.643 (90.590) 97.654 (80.486) 0.99916 alk.phos (mean (SD)) 2021.297 (2183.436) 1943.010 (2101.687) 0.74726 ast (mean (SD)) 120.209 (54.521) 124.965 (58.931) 0.45970 trig (mean (SD)) 124.137 (71.539) 125.252 (58.521) 0.88604 platelet (mean (SD)) 258.750 (100.325) 265.204 (90.729) 0.55451 protime (mean (SD)) 10.653 (0.851) 10.800 (1.138) 0.19714 Stratified by trt 1 2 p test n 158 154 time (mean (SD)) 2015.620 (1094.123) 1996.864 (1155.929) 0.88305 age (mean (SD)) 51.419 (11.007) 48.583 (9.958) 0.01767 bili (mean (SD)) 2.873 (3.629) 3.649 (5.282) 0.13094 chol (mean (SD)) 365.014 (209.544) 373.882 (252.485) 0.74799 albumin (mean (SD)) 3.516 (0.443) 3.524 (0.396) 0.87388 copper (mean (SD)) 97.643 (90.590) 97.654 (80.486) 0.99916 alk.phos (mean (SD)) 2021.297 (2183.436) 1943.010 (2101.687) 0.74726 ast (mean (SD)) 120.209 (54.521) 124.965 (58.931) 0.45970 trig (mean (SD)) 124.137 (71.539) 125.252 (58.521) 0.88604 platelet (mean (SD)) 258.750 (100.325) 265.204 (90.729) 0.55451 protime (mean (SD)) 10.653 (0.851) 10.800 (1.138) 0.19714 Stratified by trt 1 2 n 158 154 time (mean (SD)) 2015.62 (1094.12) 1996.86 (1155.93) age (mean (SD)) 51.42 (11.01) 48.58 (9.96) bili (mean (SD)) 2.87 (3.63) 3.65 (5.28) chol (mean (SD)) 365.01 (209.54) 373.88 (252.48) albumin (mean (SD)) 3.52 (0.44) 3.52 (0.40) copper (mean (SD)) 97.64 (90.59) 97.65 (80.49) alk.phos (mean (SD)) 2021.30 (2183.44) 1943.01 (2101.69) ast (mean (SD)) 120.21 (54.52) 124.97 (58.93) trig (mean (SD)) 124.14 (71.54) 125.25 (58.52) platelet (mean (SD)) 258.75 (100.32) 265.20 (90.73) protime (mean (SD)) 10.65 (0.85) 10.80 (1.14) Stratified by trt 1 2 n 158 154 time (mean (SD)) 2015.62 (1094.12) 1996.86 (1155.93) age (mean (SD)) 51.42 (11.01) 48.58 (9.96) bili (mean (SD)) 2.87 (3.63) 3.65 (5.28) chol (mean (SD)) 365.01 (209.54) 373.88 (252.48) albumin (mean (SD)) 3.52 (0.44) 3.52 (0.40) copper (mean (SD)) 97.64 (90.59) 97.65 (80.49) alk.phos (mean (SD)) 2021.30 (2183.44) 1943.01 (2101.69) ast (mean (SD)) 120.21 (54.52) 124.97 (58.93) trig (mean (SD)) 124.14 (71.54) 125.25 (58.52) platelet (mean (SD)) 258.75 (100.32) 265.20 (90.73) protime (mean (SD)) 10.65 (0.85) 10.80 (1.14) Stratified by trt 1 2 n 158 154 time (mean (SD)) 2015.62 (1094.12) 1996.86 (1155.93) age (mean (SD)) 51.42 (11.01) 48.58 (9.96) bili (median [IQR]) 1.40 [0.80, 3.20] 1.30 [0.72, 3.60] chol (median [IQR]) 315.50 [247.75, 417.00] 303.50 [254.25, 377.00] albumin (mean (SD)) 3.52 (0.44) 3.52 (0.40) copper (median [IQR]) 73.00 [40.00, 121.00] 73.00 [43.00, 139.00] alk.phos (median [IQR]) 1214.50 [840.75, 2028.00] 1283.00 [922.50, 1949.75] ast (mean (SD)) 120.21 (54.52) 124.97 (58.93) trig (median [IQR]) 106.00 [84.50, 146.00] 113.00 [84.50, 155.00] platelet (mean (SD)) 258.75 (100.32) 265.20 (90.73) protime (mean (SD)) 10.65 (0.85) 10.80 (1.14) Stratified by trt p test n time (mean (SD)) 0.883 age (mean (SD)) 0.018 bili (median [IQR]) 0.842 nonnorm chol (median [IQR]) 0.544 nonnorm albumin (mean (SD)) 0.874 copper (median [IQR]) 0.717 nonnorm alk.phos (median [IQR]) 0.812 nonnorm ast (mean (SD)) 0.460 trig (median [IQR]) 0.370 nonnorm platelet (mean (SD)) 0.555 protime (mean (SD)) 0.197 Stratified by trt 1 2 n 158 154 time (mean (SD)) 2015.62 (1094.12) 1996.86 (1155.93) age (mean (SD)) 51.42 (11.01) 48.58 (9.96) bili (median [IQR]) 1.40 [0.80, 3.20] 1.30 [0.72, 3.60] chol (median [IQR]) 315.50 [247.75, 417.00] 303.50 [254.25, 377.00] albumin (mean (SD)) 3.52 (0.44) 3.52 (0.40) copper (median [IQR]) 73.00 [40.00, 121.00] 73.00 [43.00, 139.00] alk.phos (median [IQR]) 1214.50 [840.75, 2028.00] 1283.00 [922.50, 1949.75] ast (mean (SD)) 120.21 (54.52) 124.97 (58.93) trig (median [IQR]) 106.00 [84.50, 146.00] 113.00 [84.50, 155.00] platelet (mean (SD)) 258.75 (100.32) 265.20 (90.73) protime (mean (SD)) 10.65 (0.85) 10.80 (1.14) Stratified by trt p test n time (mean (SD)) 0.883 age (mean (SD)) 0.018 bili (median [IQR]) 0.842 nonnorm chol (median [IQR]) 0.544 nonnorm albumin (mean (SD)) 0.874 copper (median [IQR]) 0.717 nonnorm alk.phos (median [IQR]) 0.812 nonnorm ast (mean (SD)) 0.460 trig (median [IQR]) 0.370 nonnorm platelet (mean (SD)) 0.555 protime (mean (SD)) 0.197 Stratified by trt 1 n 158 time (mean (SD)) 2015.62 (1094.12) age (mean (SD)) 51.42 (11.01) bili (median [range]) 1.40 [0.30, 20.00] chol (median [range]) 315.50 [127.00, 1712.00] albumin (mean (SD)) 3.52 (0.44) copper (median [range]) 73.00 [9.00, 588.00] alk.phos (median [range]) 1214.50 [369.00, 11552.00] ast (mean (SD)) 120.21 (54.52) trig (median [range]) 106.00 [33.00, 598.00] platelet (mean (SD)) 258.75 (100.32) protime (mean (SD)) 10.65 (0.85) Stratified by trt 2 p test n 154 time (mean (SD)) 1996.86 (1155.93) 0.883 age (mean (SD)) 48.58 (9.96) 0.018 bili (median [range]) 1.30 [0.30, 28.00] 0.842 nonnorm chol (median [range]) 303.50 [120.00, 1775.00] 0.544 nonnorm albumin (mean (SD)) 3.52 (0.40) 0.874 copper (median [range]) 73.00 [4.00, 558.00] 0.717 nonnorm alk.phos (median [range]) 1283.00 [289.00, 13862.40] 0.812 nonnorm ast (mean (SD)) 124.97 (58.93) 0.460 trig (median [range]) 113.00 [44.00, 432.00] 0.370 nonnorm platelet (mean (SD)) 265.20 (90.73) 0.555 protime (mean (SD)) 10.80 (1.14) 0.197 Stratified by trt 1 n 158 time (mean (SD)) 2015.62 (1094.12) age (mean (SD)) 51.42 (11.01) bili (median [range]) 1.40 [0.30, 20.00] chol (median [range]) 315.50 [127.00, 1712.00] albumin (mean (SD)) 3.52 (0.44) copper (median [range]) 73.00 [9.00, 588.00] alk.phos (median [range]) 1214.50 [369.00, 11552.00] ast (mean (SD)) 120.21 (54.52) trig (median [range]) 106.00 [33.00, 598.00] platelet (mean (SD)) 258.75 (100.32) protime (mean (SD)) 10.65 (0.85) Stratified by trt 2 p test n 154 time (mean (SD)) 1996.86 (1155.93) 0.883 age (mean (SD)) 48.58 (9.96) 0.018 bili (median [range]) 1.30 [0.30, 28.00] 0.842 nonnorm chol (median [range]) 303.50 [120.00, 1775.00] 0.544 nonnorm albumin (mean (SD)) 3.52 (0.40) 0.874 copper (median [range]) 73.00 [4.00, 558.00] 0.717 nonnorm alk.phos (median [range]) 1283.00 [289.00, 13862.40] 0.812 nonnorm ast (mean (SD)) 124.97 (58.93) 0.460 trig (median [range]) 113.00 [44.00, 432.00] 0.370 nonnorm platelet (mean (SD)) 265.20 (90.73) 0.555 protime (mean (SD)) 10.80 (1.14) 0.197 Stratified by trt 1 2 p test n 158 154 time (mean (SD)) 2015.62 (1094.12) 1996.86 (1155.93) 0.883 age (mean (SD)) 51.42 (11.01) 48.58 (9.96) 0.018 bili (mean (SD)) 2.87 (3.63) 3.65 (5.28) 0.131 chol (mean (SD)) 365.01 (209.54) 373.88 (252.48) 0.748 albumin (mean (SD)) 3.52 (0.44) 3.52 (0.40) 0.874 copper (mean (SD)) 97.64 (90.59) 97.65 (80.49) 0.999 alk.phos (mean (SD)) 2021.30 (2183.44) 1943.01 (2101.69) 0.747 ast (mean (SD)) 120.21 (54.52) 124.97 (58.93) 0.460 trig (mean (SD)) 124.14 (71.54) 125.25 (58.52) 0.886 platelet (mean (SD)) 258.75 (100.32) 265.20 (90.73) 0.555 protime (mean (SD)) 10.65 (0.85) 10.80 (1.14) 0.197 Stratified by trt 1 2 p test n 158 154 time (mean (SD)) 2015.62 (1094.12) 1996.86 (1155.93) 0.883 age (mean (SD)) 51.42 (11.01) 48.58 (9.96) 0.018 bili (mean (SD)) 2.87 (3.63) 3.65 (5.28) 0.131 chol (mean (SD)) 365.01 (209.54) 373.88 (252.48) 0.748 albumin (mean (SD)) 3.52 (0.44) 3.52 (0.40) 0.874 copper (mean (SD)) 97.64 (90.59) 97.65 (80.49) 0.999 alk.phos (mean (SD)) 2021.30 (2183.44) 1943.01 (2101.69) 0.747 ast (mean (SD)) 120.21 (54.52) 124.97 (58.93) 0.460 trig (mean (SD)) 124.14 (71.54) 125.25 (58.52) 0.886 platelet (mean (SD)) 258.75 (100.32) 265.20 (90.73) 0.555 protime (mean (SD)) 10.65 (0.85) 10.80 (1.14) 0.197 Stratified by trt 1 2 p test n 158 154 time 2015.62 (1094.12) 1996.86 (1155.93) 0.883 age 51.42 (11.01) 48.58 (9.96) 0.018 bili 2.87 (3.63) 3.65 (5.28) 0.131 chol 365.01 (209.54) 373.88 (252.48) 0.748 albumin 3.52 (0.44) 3.52 (0.40) 0.874 copper 97.64 (90.59) 97.65 (80.49) 0.999 alk.phos 2021.30 (2183.44) 1943.01 (2101.69) 0.747 ast 120.21 (54.52) 124.97 (58.93) 0.460 trig 124.14 (71.54) 125.25 (58.52) 0.886 platelet 258.75 (100.32) 265.20 (90.73) 0.555 protime 10.65 (0.85) 10.80 (1.14) 0.197 Stratified by trt 1 2 p test n 158 154 time 2015.62 (1094.12) 1996.86 (1155.93) 0.883 age 51.42 (11.01) 48.58 (9.96) 0.018 bili 2.87 (3.63) 3.65 (5.28) 0.131 chol 365.01 (209.54) 373.88 (252.48) 0.748 albumin 3.52 (0.44) 3.52 (0.40) 0.874 copper 97.64 (90.59) 97.65 (80.49) 0.999 alk.phos 2021.30 (2183.44) 1943.01 (2101.69) 0.747 ast 120.21 (54.52) 124.97 (58.93) 0.460 trig 124.14 (71.54) 125.25 (58.52) 0.886 platelet 258.75 (100.32) 265.20 (90.73) 0.555 protime 10.65 (0.85) 10.80 (1.14) 0.197 "Stratified by trt" "" "1" "2" "p" "test" "n" "158" "154" "" "" "time (mean (SD))" "2015.62 (1094.12)" "1996.86 (1155.93)" "0.883" "" "age (mean (SD))" "51.42 (11.01)" "48.58 (9.96)" "0.018" "" "bili (mean (SD))" "2.87 (3.63)" "3.65 (5.28)" "0.131" "" "chol (mean (SD))" "365.01 (209.54)" "373.88 (252.48)" "0.748" "" "albumin (mean (SD))" "3.52 (0.44)" "3.52 (0.40)" "0.874" "" "copper (mean (SD))" "97.64 (90.59)" "97.65 (80.49)" "0.999" "" "alk.phos (mean (SD))" "2021.30 (2183.44)" "1943.01 (2101.69)" "0.747" "" "ast (mean (SD))" "120.21 (54.52)" "124.97 (58.93)" "0.460" "" "trig (mean (SD))" "124.14 (71.54)" "125.25 (58.52)" "0.886" "" "platelet (mean (SD))" "258.75 (100.32)" "265.20 (90.73)" "0.555" "" "protime (mean (SD))" "10.65 (0.85)" "10.80 (1.14)" "0.197" "" "Stratified by trt" "" "1" "2" "p" "test" "n" "158" "154" "" "" "time (mean (SD))" "2015.62 (1094.12)" "1996.86 (1155.93)" "0.883" "" "age (mean (SD))" "51.42 (11.01)" "48.58 (9.96)" "0.018" "" "bili (mean (SD))" "2.87 (3.63)" "3.65 (5.28)" "0.131" "" "chol (mean (SD))" "365.01 (209.54)" "373.88 (252.48)" "0.748" "" "albumin (mean (SD))" "3.52 (0.44)" "3.52 (0.40)" "0.874" "" "copper (mean (SD))" "97.64 (90.59)" "97.65 (80.49)" "0.999" "" "alk.phos (mean (SD))" "2021.30 (2183.44)" "1943.01 (2101.69)" "0.747" "" "ast (mean (SD))" "120.21 (54.52)" "124.97 (58.93)" "0.460" "" "trig (mean (SD))" "124.14 (71.54)" "125.25 (58.52)" "0.886" "" "platelet (mean (SD))" "258.75 (100.32)" "265.20 (90.73)" "0.555" "" "protime (mean (SD))" "10.65 (0.85)" "10.80 (1.14)" "0.197" "" "Stratified by trt" "" "Overall" "1" "n" "418" "158" "time (mean (SD))" "1917.78 (1104.67)" "2015.62 (1094.12)" "age (mean (SD))" "50.74 (10.45)" "51.42 (11.01)" "bili (mean (SD))" "3.22 (4.41)" "2.87 (3.63)" "chol (mean (SD))" "369.51 (231.94)" "365.01 (209.54)" "albumin (mean (SD))" "3.50 (0.42)" "3.52 (0.44)" "copper (mean (SD))" "97.65 (85.61)" "97.64 (90.59)" "alk.phos (mean (SD))" "1982.66 (2140.39)" "2021.30 (2183.44)" "ast (mean (SD))" "122.56 (56.70)" "120.21 (54.52)" "trig (mean (SD))" "124.70 (65.15)" "124.14 (71.54)" "platelet (mean (SD))" "257.02 (98.33)" "258.75 (100.32)" "protime (mean (SD))" "10.73 (1.02)" "10.65 (0.85)" "Stratified by trt" "" "2" "p" "test" "SMD" "n" "154" "" "" "" "time (mean (SD))" "1996.86 (1155.93)" "0.883" "" "0.017" "age (mean (SD))" "48.58 (9.96)" "0.018" "" "0.270" "bili (mean (SD))" "3.65 (5.28)" "0.131" "" "0.171" "chol (mean (SD))" "373.88 (252.48)" "0.748" "" "0.038" "albumin (mean (SD))" "3.52 (0.40)" "0.874" "" "0.018" "copper (mean (SD))" "97.65 (80.49)" "0.999" "" "<0.001" "alk.phos (mean (SD))" "1943.01 (2101.69)" "0.747" "" "0.037" "ast (mean (SD))" "124.97 (58.93)" "0.460" "" "0.084" "trig (mean (SD))" "125.25 (58.52)" "0.886" "" "0.017" "platelet (mean (SD))" "265.20 (90.73)" "0.555" "" "0.067" "protime (mean (SD))" "10.80 (1.14)" "0.197" "" "0.146" "Stratified by trt" "" "Overall" "1" "n" "418" "158" "time (mean (SD))" "1917.78 (1104.67)" "2015.62 (1094.12)" "age (mean (SD))" "50.74 (10.45)" "51.42 (11.01)" "bili (mean (SD))" "3.22 (4.41)" "2.87 (3.63)" "chol (mean (SD))" "369.51 (231.94)" "365.01 (209.54)" "albumin (mean (SD))" "3.50 (0.42)" "3.52 (0.44)" "copper (mean (SD))" "97.65 (85.61)" "97.64 (90.59)" "alk.phos (mean (SD))" "1982.66 (2140.39)" "2021.30 (2183.44)" "ast (mean (SD))" "122.56 (56.70)" "120.21 (54.52)" "trig (mean (SD))" "124.70 (65.15)" "124.14 (71.54)" "platelet (mean (SD))" "257.02 (98.33)" "258.75 (100.32)" "protime (mean (SD))" "10.73 (1.02)" "10.65 (0.85)" "Stratified by trt" "" "2" "p" "test" "SMD" "n" "154" "" "" "" "time (mean (SD))" "1996.86 (1155.93)" "0.883" "" "0.017" "age (mean (SD))" "48.58 (9.96)" "0.018" "" "0.270" "bili (mean (SD))" "3.65 (5.28)" "0.131" "" "0.171" "chol (mean (SD))" "373.88 (252.48)" "0.748" "" "0.038" "albumin (mean (SD))" "3.52 (0.40)" "0.874" "" "0.018" "copper (mean (SD))" "97.65 (80.49)" "0.999" "" "<0.001" "alk.phos (mean (SD))" "1943.01 (2101.69)" "0.747" "" "0.037" "ast (mean (SD))" "124.97 (58.93)" "0.460" "" "0.084" "trig (mean (SD))" "125.25 (58.52)" "0.886" "" "0.017" "platelet (mean (SD))" "265.20 (90.73)" "0.555" "" "0.067" "protime (mean (SD))" "10.80 (1.14)" "0.197" "" "0.146" Stratified by trt:sex Overall 1:m 2:m n 418 21 15 time (mean (SD)) 1917.78 (1104.67) 1793.48 (1244.70) 2156.33 (1428.56) age (mean (SD)) 50.74 (10.45) 55.57 (12.61) 57.09 (10.07) bili (mean (SD)) 3.22 (4.41) 2.98 (2.11) 2.72 (2.46) chol (mean (SD)) 369.51 (231.94) 403.43 (204.95) 301.00 (111.32) albumin (mean (SD)) 3.50 (0.42) 3.63 (0.43) 3.50 (0.49) copper (mean (SD)) 97.65 (85.61) 174.90 (105.33) 125.40 (89.18) alk.phos (mean (SD)) 1982.66 (2140.39) 2486.16 (2385.32) 1734.45 (2478.07) ast (mean (SD)) 122.56 (56.70) 128.71 (48.74) 112.58 (44.38) trig (mean (SD)) 124.70 (65.15) 145.81 (56.62) 114.86 (39.59) platelet (mean (SD)) 257.02 (98.33) 232.65 (97.38) 240.13 (73.93) protime (mean (SD)) 10.73 (1.02) 10.84 (0.94) 11.23 (0.97) Stratified by trt:sex 1:f 2:f p test n 137 139 time (mean (SD)) 2049.67 (1070.20) 1979.65 (1127.52) 0.730 age (mean (SD)) 50.78 (10.65) 47.66 (9.54) <0.001 bili (mean (SD)) 2.86 (3.81) 3.75 (5.50) 0.394 chol (mean (SD)) 358.24 (210.46) 381.73 (262.26) 0.512 albumin (mean (SD)) 3.50 (0.44) 3.53 (0.39) 0.585 copper (mean (SD)) 85.71 (82.27) 94.64 (79.25) <0.001 alk.phos (mean (SD)) 1950.04 (2151.35) 1965.52 (2066.15) 0.706 ast (mean (SD)) 118.91 (55.40) 126.30 (60.27) 0.598 trig (mean (SD)) 120.28 (73.41) 126.38 (60.22) 0.370 platelet (mean (SD)) 262.59 (100.53) 267.95 (92.20) 0.362 protime (mean (SD)) 10.62 (0.84) 10.75 (1.15) 0.137 Stratified by trt:sex Overall 1:m 2:m n 418 21 15 time (mean (SD)) 1917.78 (1104.67) 1793.48 (1244.70) 2156.33 (1428.56) age (mean (SD)) 50.74 (10.45) 55.57 (12.61) 57.09 (10.07) bili (mean (SD)) 3.22 (4.41) 2.98 (2.11) 2.72 (2.46) chol (mean (SD)) 369.51 (231.94) 403.43 (204.95) 301.00 (111.32) albumin (mean (SD)) 3.50 (0.42) 3.63 (0.43) 3.50 (0.49) copper (mean (SD)) 97.65 (85.61) 174.90 (105.33) 125.40 (89.18) alk.phos (mean (SD)) 1982.66 (2140.39) 2486.16 (2385.32) 1734.45 (2478.07) ast (mean (SD)) 122.56 (56.70) 128.71 (48.74) 112.58 (44.38) trig (mean (SD)) 124.70 (65.15) 145.81 (56.62) 114.86 (39.59) platelet (mean (SD)) 257.02 (98.33) 232.65 (97.38) 240.13 (73.93) protime (mean (SD)) 10.73 (1.02) 10.84 (0.94) 11.23 (0.97) Stratified by trt:sex 1:f 2:f p test n 137 139 time (mean (SD)) 2049.67 (1070.20) 1979.65 (1127.52) 0.730 age (mean (SD)) 50.78 (10.65) 47.66 (9.54) <0.001 bili (mean (SD)) 2.86 (3.81) 3.75 (5.50) 0.394 chol (mean (SD)) 358.24 (210.46) 381.73 (262.26) 0.512 albumin (mean (SD)) 3.50 (0.44) 3.53 (0.39) 0.585 copper (mean (SD)) 85.71 (82.27) 94.64 (79.25) <0.001 alk.phos (mean (SD)) 1950.04 (2151.35) 1965.52 (2066.15) 0.706 ast (mean (SD)) 118.91 (55.40) 126.30 (60.27) 0.598 trig (mean (SD)) 120.28 (73.41) 126.38 (60.22) 0.370 platelet (mean (SD)) 262.59 (100.53) 267.95 (92.20) 0.362 protime (mean (SD)) 10.62 (0.84) 10.75 (1.15) 0.137 ### Summary of continuous variables ### strata: Overall n miss p.miss mean sd median p25 p75 min max skew kurt time 418 0 0.0 1918 1e+03 1730 1e+03 2614 41.0 4795 0.47 -0.5 age 418 0 0.0 51 1e+01 51 4e+01 58 26.3 78 0.09 -0.6 bili 418 0 0.0 3 4e+00 1 8e-01 3 0.3 28 2.72 8.1 chol 418 134 32.1 370 2e+02 310 2e+02 400 120.0 1775 3.41 14.3 albumin 418 0 0.0 3 4e-01 4 3e+00 4 2.0 5 -0.47 0.6 copper 418 108 25.8 98 9e+01 73 4e+01 123 4.0 588 2.30 7.6 alk.phos 418 106 25.4 1983 2e+03 1259 9e+02 1980 289.0 13862 2.99 9.7 ast 418 106 25.4 123 6e+01 115 8e+01 152 26.4 457 1.45 4.3 trig 418 136 32.5 125 7e+01 108 8e+01 151 33.0 598 2.52 11.8 platelet 418 11 2.6 257 1e+02 251 2e+02 318 62.0 721 0.63 0.9 protime 418 2 0.5 11 1e+00 11 1e+01 11 9.0 18 2.22 10.0 ======================================================================================= ### Summary of categorical variables ### strata: Overall var n miss p.miss level freq percent cum.percent status 418 0 0.0 0 232 55.5 55.5 1 25 6.0 61.5 2 161 38.5 100.0 sex 418 0 0.0 m 44 10.5 10.5 f 374 89.5 100.0 ascites 418 106 25.4 0 288 92.3 92.3 1 24 7.7 100.0 hepato 418 106 25.4 0 152 48.7 48.7 1 160 51.3 100.0 spiders 418 106 25.4 0 222 71.2 71.2 1 90 28.8 100.0 edema 418 0 0.0 0 354 84.7 84.7 0.5 44 10.5 95.2 1 20 4.8 100.0 stage 418 6 1.4 1 21 5.1 5.1 2 92 22.3 27.4 3 155 37.6 65.0 4 144 35.0 100.0 ### Summary of continuous variables ### strata: Overall n miss p.miss mean sd median p25 p75 min max skew kurt time 418 0 0.0 1918 1e+03 1730 1e+03 2614 41.0 4795 0.47 -0.5 age 418 0 0.0 51 1e+01 51 4e+01 58 26.3 78 0.09 -0.6 bili 418 0 0.0 3 4e+00 1 8e-01 3 0.3 28 2.72 8.1 chol 418 134 32.1 370 2e+02 310 2e+02 400 120.0 1775 3.41 14.3 albumin 418 0 0.0 3 4e-01 4 3e+00 4 2.0 5 -0.47 0.6 copper 418 108 25.8 98 9e+01 73 4e+01 123 4.0 588 2.30 7.6 alk.phos 418 106 25.4 1983 2e+03 1259 9e+02 1980 289.0 13862 2.99 9.7 ast 418 106 25.4 123 6e+01 115 8e+01 152 26.4 457 1.45 4.3 trig 418 136 32.5 125 7e+01 108 8e+01 151 33.0 598 2.52 11.8 platelet 418 11 2.6 257 1e+02 251 2e+02 318 62.0 721 0.63 0.9 protime 418 2 0.5 11 1e+00 11 1e+01 11 9.0 18 2.22 10.0 ======================================================================================= ### Summary of categorical variables ### strata: Overall var n miss p.miss level freq percent cum.percent status 418 0 0.0 0 232 55.5 55.5 1 25 6.0 61.5 2 161 38.5 100.0 sex 418 0 0.0 m 44 10.5 10.5 f 374 89.5 100.0 ascites 418 0 0.0 0 288 68.9 68.9 1 24 5.7 74.6 106 25.4 100.0 hepato 418 0 0.0 0 152 36.4 36.4 1 160 38.3 74.6 106 25.4 100.0 spiders 418 0 0.0 0 222 53.1 53.1 1 90 21.5 74.6 106 25.4 100.0 edema 418 0 0.0 0 354 84.7 84.7 0.5 44 10.5 95.2 1 20 4.8 100.0 stage 418 0 0.0 1 21 5.0 5.0 2 92 22.0 27.0 3 155 37.1 64.1 4 144 34.4 98.6 6 1.4 100.0 ### Summary of continuous variables ### trt: 1 n miss p.miss mean sd median p25 p75 min max skew kurt time 158 0 0.0 2016 1e+03 1895 1e+03 2632 41.0 4556 0.41 -0.4 age 158 0 0.0 51 1e+01 52 4e+01 59 26.3 78 0.06 -0.5 bili 158 0 0.0 3 4e+00 1 8e-01 3 0.3 20 2.67 7.6 chol 158 18 11.4 365 2e+02 316 2e+02 417 127.0 1712 3.83 20.2 albumin 158 0 0.0 4 4e-01 4 3e+00 4 2.1 5 -0.40 0.3 copper 158 1 0.6 98 9e+01 73 4e+01 121 9.0 588 2.50 8.2 alk.phos 158 0 0.0 2021 2e+03 1214 8e+02 2028 369.0 11552 2.71 7.4 ast 158 0 0.0 120 5e+01 112 8e+01 152 26.4 338 1.09 1.6 trig 158 19 12.0 124 7e+01 106 8e+01 146 33.0 598 2.95 14.3 platelet 158 2 1.3 259 1e+02 255 2e+02 322 62.0 563 0.50 0.2 protime 158 0 0.0 11 9e-01 11 1e+01 11 9.0 14 1.10 1.6 ------------------------------------------------------------ trt: 2 n miss p.miss mean sd median p25 p75 min max skew kurt time 154 0 0.0 1997 1e+03 1811 1e+03 2771 51.0 4523 0.4 -0.7 age 154 0 0.0 49 1e+01 48 4e+01 56 30.6 75 0.2 -0.5 bili 154 0 0.0 4 5e+00 1 7e-01 4 0.3 28 2.7 7.3 chol 154 10 6.5 374 3e+02 304 3e+02 377 120.0 1775 3.1 11.1 albumin 154 0 0.0 4 4e-01 4 3e+00 4 2.0 4 -0.8 2.0 copper 154 1 0.6 98 8e+01 73 4e+01 139 4.0 558 2.0 6.6 alk.phos 154 0 0.0 1943 2e+03 1283 9e+02 1950 289.0 13862 3.3 12.8 ast 154 0 0.0 125 6e+01 117 8e+01 152 28.4 457 1.7 6.3 trig 154 11 7.1 125 6e+01 113 8e+01 155 44.0 432 1.7 5.5 platelet 154 2 1.3 265 9e+01 260 2e+02 322 71.0 487 0.2 -0.3 protime 154 0 0.0 11 1e+00 11 1e+01 11 9.2 17 1.9 6.4 p-values pNormal pNonNormal time 0.88304691 0.82661809 age 0.01767247 0.01962155 bili 0.13093942 0.84168460 chol 0.74799072 0.54433899 albumin 0.87388074 0.95045176 copper 0.99915849 0.71745444 alk.phos 0.74726165 0.81198200 ast 0.45969842 0.45892358 trig 0.88604213 0.36980434 platelet 0.55451136 0.45482564 protime 0.19714026 0.58802048 Standardize mean differences 1 vs 2 time 0.0166658751 age 0.2702619258 bili 0.1710905651 chol 0.0382210537 albumin 0.0180021838 copper 0.0001200022 alk.phos 0.0365323630 ast 0.0837836058 trig 0.0170615337 platelet 0.0674763888 protime 0.1460939117 ======================================================================================= ### Summary of categorical variables ### trt: 1 var n miss p.miss level freq percent cum.percent status 158 0 0.0 0 83 52.5 52.5 1 10 6.3 58.9 2 65 41.1 100.0 sex 158 0 0.0 m 21 13.3 13.3 f 137 86.7 100.0 ascites 158 0 0.0 0 144 91.1 91.1 1 14 8.9 100.0 hepato 158 0 0.0 0 85 53.8 53.8 1 73 46.2 100.0 spiders 158 0 0.0 0 113 71.5 71.5 1 45 28.5 100.0 edema 158 0 0.0 0 132 83.5 83.5 0.5 16 10.1 93.7 1 10 6.3 100.0 stage 158 0 0.0 1 12 7.6 7.6 2 35 22.2 29.7 3 56 35.4 65.2 4 55 34.8 100.0 ------------------------------------------------------------ trt: 2 var n miss p.miss level freq percent cum.percent status 154 0 0.0 0 85 55.2 55.2 1 9 5.8 61.0 2 60 39.0 100.0 sex 154 0 0.0 m 15 9.7 9.7 f 139 90.3 100.0 ascites 154 0 0.0 0 144 93.5 93.5 1 10 6.5 100.0 hepato 154 0 0.0 0 67 43.5 43.5 1 87 56.5 100.0 spiders 154 0 0.0 0 109 70.8 70.8 1 45 29.2 100.0 edema 154 0 0.0 0 131 85.1 85.1 0.5 13 8.4 93.5 1 10 6.5 100.0 stage 154 0 0.0 1 4 2.6 2.6 2 32 20.8 23.4 3 64 41.6 64.9 4 54 35.1 100.0 p-values pApprox pExact status 0.89350975 0.88422188 sex 0.42122610 0.37743235 ascites 0.56728647 0.52558267 hepato 0.08820884 0.07137522 spiders 0.98466036 0.90113734 edema 0.87681949 0.89370131 stage 0.20129629 0.20455558 Standardize mean differences 1 vs 2 status 0.05375763 sex 0.11141161 ascites 0.08900618 hepato 0.20699413 spiders 0.01632844 edema 0.05811659 stage 0.24600834 ### Summary of continuous variables ### trt: 1 sex: m n miss p.miss mean sd median p25 p75 min max skew kurt time 21 0 0 1793 1e+03 1302 999 2386 140.0 4459 1.04 0.1 age 21 0 0 56 1e+01 56 46 66 33.5 78 -0.20 -0.7 bili 21 0 0 3 2e+00 2 1 4 0.6 7 1.02 -0.1 chol 21 0 0 403 2e+02 376 251 456 168.0 1000 1.33 2.2 albumin 21 0 0 4 4e-01 4 3 4 2.6 4 -0.97 0.3 copper 21 0 0 175 1e+02 158 100 225 25.0 444 1.08 1.0 alk.phos 21 0 0 2486 2e+03 1664 983 2496 516.0 10165 2.05 4.5 ast 21 0 0 129 5e+01 127 86 158 56.8 222 0.31 -0.9 trig 21 0 0 146 6e+01 142 107 194 55.0 242 0.16 -1.0 platelet 21 1 5 233 1e+02 228 148 314 70.0 394 -0.05 -1.2 protime 21 0 0 11 9e-01 11 10 11 9.7 14 2.11 6.8 ------------------------------------------------------------ trt: 2 sex: m n miss p.miss mean sd median p25 p75 min max skew kurt time 15 0 0 2156 1e+03 1656 1054 3420 191.0 4427 0.3 -1.4 age 15 0 0 57 1e+01 53 49 66 43.9 75 0.5 -1.3 bili 15 0 0 3 2e+00 2 1 3 0.6 9 1.5 1.4 chol 15 1 7 301 1e+02 259 236 342 151.0 546 0.9 0.4 albumin 15 0 0 4 5e-01 4 3 4 2.3 4 -1.0 1.9 copper 15 0 0 125 9e+01 84 52 198 13.0 281 0.5 -1.1 alk.phos 15 0 0 1734 2e+03 1070 737 1212 577.0 10397 3.5 12.7 ast 15 0 0 113 4e+01 110 74 129 46.5 188 0.3 -0.8 trig 15 1 7 115 4e+01 108 90 137 49.0 188 0.4 -0.4 platelet 15 0 0 240 7e+01 214 190 294 119.0 360 0.2 -1.0 protime 15 0 0 11 1e+00 11 11 12 10.0 13 0.7 0.2 ------------------------------------------------------------ trt: 1 sex: f n miss p.miss mean sd median p25 p75 min max skew kurt time 137 0 0.0 2050 1e+03 1945 1e+03 2644 41.0 4556 0.32 -0.4 age 137 0 0.0 51 1e+01 51 4e+01 57 26.3 77 0.05 -0.5 bili 137 0 0.0 3 4e+00 1 8e-01 3 0.3 20 2.65 7.1 chol 137 18 13.1 358 2e+02 309 2e+02 400 127.0 1712 4.28 23.8 albumin 137 0 0.0 3 4e-01 4 3e+00 4 2.1 5 -0.33 0.4 copper 137 1 0.7 86 8e+01 67 4e+01 105 9.0 588 3.18 13.9 alk.phos 137 0 0.0 1950 2e+03 1212 8e+02 1877 369.0 11552 2.88 8.4 ast 137 0 0.0 119 6e+01 108 7e+01 150 26.4 338 1.20 1.9 trig 137 19 13.9 120 7e+01 101 8e+01 134 33.0 598 3.28 16.0 platelet 137 1 0.7 263 1e+02 258 2e+02 322 62.0 563 0.57 0.3 protime 137 0 0.0 11 8e-01 11 1e+01 11 9.0 13 0.92 0.6 ------------------------------------------------------------ trt: 2 sex: f n miss p.miss mean sd median p25 p75 min max skew kurt time 139 0 0.0 1980 1e+03 1832 1e+03 2717 51.0 4523 0.3 -0.6 age 139 0 0.0 48 1e+01 47 4e+01 55 30.6 71 0.2 -0.7 bili 139 0 0.0 4 5e+00 1 7e-01 4 0.3 28 2.6 6.5 chol 139 9 6.5 382 3e+02 306 3e+02 381 120.0 1775 3.0 10.1 albumin 139 0 0.0 4 4e-01 4 3e+00 4 2.0 4 -0.8 2.1 copper 139 1 0.7 95 8e+01 70 4e+01 127 4.0 558 2.2 8.3 alk.phos 139 0 0.0 1966 2e+03 1345 9e+02 1992 289.0 13862 3.4 13.6 ast 139 0 0.0 126 6e+01 118 8e+01 153 28.4 457 1.8 6.2 trig 139 10 7.2 126 6e+01 113 8e+01 157 44.0 432 1.7 5.3 platelet 139 2 1.4 268 9e+01 265 2e+02 324 71.0 487 0.2 -0.4 protime 139 0 0.0 11 1e+00 11 1e+01 11 9.2 17 2.0 7.2 p-values pNormal pNonNormal time 7.300496e-01 5.566440e-01 age 1.286381e-04 6.517437e-04 bili 3.937430e-01 2.049525e-01 chol 5.122223e-01 4.578773e-01 albumin 5.853926e-01 4.041206e-01 copper 6.237989e-05 4.712924e-05 alk.phos 7.063812e-01 1.801480e-01 ast 5.982898e-01 5.086616e-01 trig 3.701073e-01 5.827726e-02 platelet 3.624740e-01 4.451277e-01 protime 1.365463e-01 8.114383e-02 Standardize mean differences average 1 vs 2 1 vs 3 1 vs 4 2 vs 3 2 vs 4 time 0.1556365 0.27083134 0.22071813 0.15677410 0.08450703 0.13729269 age 0.5214974 0.13353519 0.40993004 0.70700091 0.60864596 0.96133382 bili 0.1352025 0.11373946 0.04023105 0.18444097 0.04265701 0.24158721 chol 0.2950579 0.62108339 0.21756422 0.09219212 0.33996564 0.40072828 albumin 0.1637683 0.28262444 0.30878937 0.26228013 0.01074465 0.05159074 copper 0.5416574 0.50727571 0.94378898 0.86116098 0.46259003 0.36464167 alk.phos 0.1633259 0.30907333 0.23603622 0.23332162 0.09290687 0.10128012 ast 0.1818681 0.34614452 0.18797132 0.04399580 0.12602823 0.25929154 trig 0.2940632 0.63360898 0.38944815 0.33242327 0.09194315 0.22610097 platelet 0.2340433 0.08655951 0.30251429 0.37226635 0.25448008 0.33286083 protime 0.3283721 0.40162254 0.24596092 0.08476002 0.66430044 0.44433997 3 vs 4 time 0.06369595 age 0.30853876 bili 0.18855913 chol 0.09881382 albumin 0.06658036 copper 0.11048709 alk.phos 0.00733728 ast 0.12777729 trig 0.09085446 platelet 0.05557853 protime 0.12924857 ======================================================================================= ### Summary of categorical variables ### trt: 1 sex: m var n miss p.miss level freq percent cum.percent status 21 0 0.0 0 4 19.0 19.0 1 3 14.3 33.3 2 14 66.7 100.0 sex 21 0 0.0 m 21 100.0 100.0 f 0 0.0 100.0 ascites 21 0 0.0 0 20 95.2 95.2 1 1 4.8 100.0 hepato 21 0 0.0 0 9 42.9 42.9 1 12 57.1 100.0 spiders 21 0 0.0 0 18 85.7 85.7 1 3 14.3 100.0 edema 21 0 0.0 0 17 81.0 81.0 0.5 3 14.3 95.2 1 1 4.8 100.0 stage 21 0 0.0 1 2 9.5 9.5 2 4 19.0 28.6 3 7 33.3 61.9 4 8 38.1 100.0 ------------------------------------------------------------ trt: 2 sex: m var n miss p.miss level freq percent cum.percent status 15 0 0.0 0 7 46.7 46.7 1 0 0.0 46.7 2 8 53.3 100.0 sex 15 0 0.0 m 15 100.0 100.0 f 0 0.0 100.0 ascites 15 0 0.0 0 13 86.7 86.7 1 2 13.3 100.0 hepato 15 0 0.0 0 6 40.0 40.0 1 9 60.0 100.0 spiders 15 0 0.0 0 14 93.3 93.3 1 1 6.7 100.0 edema 15 0 0.0 0 12 80.0 80.0 0.5 1 6.7 86.7 1 2 13.3 100.0 stage 15 0 0.0 1 1 6.7 6.7 2 2 13.3 20.0 3 5 33.3 53.3 4 7 46.7 100.0 ------------------------------------------------------------ trt: 1 sex: f var n miss p.miss level freq percent cum.percent status 137 0 0.0 0 79 57.7 57.7 1 7 5.1 62.8 2 51 37.2 100.0 sex 137 0 0.0 m 0 0.0 0.0 f 137 100.0 100.0 ascites 137 0 0.0 0 124 90.5 90.5 1 13 9.5 100.0 hepato 137 0 0.0 0 76 55.5 55.5 1 61 44.5 100.0 spiders 137 0 0.0 0 95 69.3 69.3 1 42 30.7 100.0 edema 137 0 0.0 0 115 83.9 83.9 0.5 13 9.5 93.4 1 9 6.6 100.0 stage 137 0 0.0 1 10 7.3 7.3 2 31 22.6 29.9 3 49 35.8 65.7 4 47 34.3 100.0 ------------------------------------------------------------ trt: 2 sex: f var n miss p.miss level freq percent cum.percent status 139 0 0.0 0 78 56.1 56.1 1 9 6.5 62.6 2 52 37.4 100.0 sex 139 0 0.0 m 0 0.0 0.0 f 139 100.0 100.0 ascites 139 0 0.0 0 131 94.2 94.2 1 8 5.8 100.0 hepato 139 0 0.0 0 61 43.9 43.9 1 78 56.1 100.0 spiders 139 0 0.0 0 95 68.3 68.3 1 44 31.7 100.0 edema 139 0 0.0 0 119 85.6 85.6 0.5 12 8.6 94.2 1 8 5.8 100.0 stage 139 0 0.0 1 3 2.2 2.2 2 30 21.6 23.7 3 59 42.4 66.2 4 47 33.8 100.0 p-values pApprox pExact status 3.269881e-02 2.420814e-02 sex 2.514569e-67 4.934035e-48 ascites 5.156942e-01 4.354075e-01 hepato 2.080568e-01 2.048012e-01 spiders 8.898575e-02 8.569292e-02 edema 9.058420e-01 8.483322e-01 stage 6.463005e-01 NA Standardize mean differences average 1 vs 2 1 vs 3 1 vs 4 2 vs 3 2 vs 4 status 0.5770647 0.79644734 0.8748771 0.83097631 0.4375075 0.46214324 sex NaN 0.00000000 NaN NaN NaN NaN ascites 0.1755851 0.30219043 0.1845375 0.04452096 0.1211310 0.26007640 hepato 0.1598214 0.05802589 0.2544151 0.02073917 0.3135916 0.07878788 spiders 0.4018377 0.25073566 0.3999925 0.42200838 0.6471968 0.66954801 edema 0.2122338 0.37625250 0.1624118 0.18063879 0.2420277 0.26502087 stage 0.2773411 0.21945509 0.1333844 0.35632272 0.3000785 0.39205566 3 vs 4 status 0.06043662 sex 0.00000000 ascites 0.14105454 hepato 0.23336861 spiders 0.02154469 edema 0.04705137 stage 0.26275030 ### Summary of continuous variables ### trt: 1 sex: m n miss p.miss mean sd median p25 p75 min max skew kurt time 21 0 0 1793 1e+03 1302 999 2386 140 4459 1.0 0.1 age 21 0 0 56 1e+01 56 46 66 33 78 -0.2 -0.7 protime 21 0 0 11 9e-01 11 10 11 10 14 2.1 6.8 ------------------------------------------------------------ trt: 2 sex: m n miss p.miss mean sd median p25 p75 min max skew kurt time 15 0 0 2156 1429 1656 1054 3420 191 4427 0.3 -1.4 age 15 0 0 57 10 53 49 66 44 75 0.5 -1.3 protime 15 0 0 11 1 11 11 12 10 13 0.7 0.2 ------------------------------------------------------------ trt: 1 sex: f n miss p.miss mean sd median p25 p75 min max skew kurt time 137 0 0 2050 1e+03 1945 1293 2644 41 4556 0.32 -0.4 age 137 0 0 51 1e+01 51 43 57 26 77 0.05 -0.5 protime 137 0 0 11 8e-01 11 10 11 9 13 0.92 0.6 ------------------------------------------------------------ trt: 2 sex: f n miss p.miss mean sd median p25 p75 min max skew kurt time 139 0 0 1980 1128 1832 1157 2717 51 4523 0.3 -0.6 age 139 0 0 48 10 47 41 55 31 71 0.2 -0.7 protime 139 0 0 11 1 11 10 11 9 17 2.0 7.2 p-values pNormal pNonNormal time 0.7300495976 0.5566439797 age 0.0001286381 0.0006517437 protime 0.1365463300 0.0811438294 Standardize mean differences average 1 vs 2 1 vs 3 1 vs 4 2 vs 3 2 vs 4 time 0.1556365 0.2708313 0.2207181 0.15677410 0.08450703 0.1372927 age 0.5214974 0.1335352 0.4099300 0.70700091 0.60864596 0.9613338 protime 0.3283721 0.4016225 0.2459609 0.08476002 0.66430044 0.4443400 3 vs 4 time 0.06369595 age 0.30853876 protime 0.12924857 ### Summary of categorical variables ### trt: 1 sex: m var n miss p.miss level freq percent cum.percent status 21 0 0.0 0 4 19.0 19.0 1 3 14.3 33.3 2 14 66.7 100.0 trt 21 0 0.0 1 21 100.0 100.0 2 0 0.0 100.0 sex 21 0 0.0 m 21 100.0 100.0 f 0 0.0 100.0 ------------------------------------------------------------ trt: 2 sex: m var n miss p.miss level freq percent cum.percent status 15 0 0.0 0 7 46.7 46.7 1 0 0.0 46.7 2 8 53.3 100.0 trt 15 0 0.0 1 0 0.0 0.0 2 15 100.0 100.0 sex 15 0 0.0 m 15 100.0 100.0 f 0 0.0 100.0 ------------------------------------------------------------ trt: 1 sex: f var n miss p.miss level freq percent cum.percent status 137 0 0.0 0 79 57.7 57.7 1 7 5.1 62.8 2 51 37.2 100.0 trt 137 0 0.0 1 137 100.0 100.0 2 0 0.0 100.0 sex 137 0 0.0 m 0 0.0 0.0 f 137 100.0 100.0 ------------------------------------------------------------ trt: 2 sex: f var n miss p.miss level freq percent cum.percent status 139 0 0.0 0 78 56.1 56.1 1 9 6.5 62.6 2 52 37.4 100.0 trt 139 0 0.0 1 0 0.0 0.0 2 139 100.0 100.0 sex 139 0 0.0 m 0 0.0 0.0 f 139 100.0 100.0 p-values pApprox pExact status 3.269881e-02 2.420814e-02 trt 2.514569e-67 2.724125e-93 sex 2.514569e-67 4.934035e-48 Standardize mean differences average 1 vs 2 1 vs 3 1 vs 4 2 vs 3 2 vs 4 3 vs 4 status 0.5770647 0.7964473 0.8748771 0.8309763 0.4375075 0.4621432 0.06043662 trt NaN NaN 0.0000000 NaN NaN 0.0000000 NaN sex NaN 0.0000000 NaN NaN NaN NaN 0.00000000 average 1 vs 2 1 vs 3 1 vs 4 2 vs 3 2 vs 4 time 0.1556365 0.27083134 0.22071813 0.15677410 0.08450703 0.13729269 status 0.5770647 0.79644734 0.87487707 0.83097631 0.43750751 0.46214324 age 0.5214974 0.13353519 0.40993004 0.70700091 0.60864596 0.96133382 sex NaN 0.00000000 NaN NaN NaN NaN ascites 0.1755851 0.30219043 0.18453749 0.04452096 0.12113103 0.26007640 hepato 0.1598214 0.05802589 0.25441512 0.02073917 0.31359163 0.07878788 spiders 0.4018377 0.25073566 0.39999254 0.42200838 0.64719678 0.66954801 edema 0.2122338 0.37625250 0.16241184 0.18063879 0.24202772 0.26502087 bili 0.1352025 0.11373946 0.04023105 0.18444097 0.04265701 0.24158721 chol 0.2950579 0.62108339 0.21756422 0.09219212 0.33996564 0.40072828 albumin 0.1637683 0.28262444 0.30878937 0.26228013 0.01074465 0.05159074 copper 0.5416574 0.50727571 0.94378898 0.86116098 0.46259003 0.36464167 alk.phos 0.1633259 0.30907333 0.23603622 0.23332162 0.09290687 0.10128012 ast 0.1818681 0.34614452 0.18797132 0.04399580 0.12602823 0.25929154 trig 0.2940632 0.63360898 0.38944815 0.33242327 0.09194315 0.22610097 platelet 0.2340433 0.08655951 0.30251429 0.37226635 0.25448008 0.33286083 protime 0.3283721 0.40162254 0.24596092 0.08476002 0.66430044 0.44433997 stage 0.2773411 0.21945509 0.13338440 0.35632272 0.30007852 0.39205566 3 vs 4 time 0.06369595 status 0.06043662 age 0.30853876 sex 0.00000000 ascites 0.14105454 hepato 0.23336861 spiders 0.02154469 edema 0.04705137 bili 0.18855913 chol 0.09881382 albumin 0.06658036 copper 0.11048709 alk.phos 0.00733728 ast 0.12777729 trig 0.09085446 platelet 0.05557853 protime 0.12924857 stage 0.26275030 average 1 vs 2 1 vs 3 1 vs 4 2 vs 3 2 vs 4 HI_CHOL 0.07290304 0.06404806 0.07986822 0.006024398 0.14361148 0.07003988 race NaN NaN NaN NaN NaN NaN agecat 0.26102029 0.47958417 0.21054511 0.163093544 0.26927031 0.33972601 RIAGENDR 0.06902841 0.04460885 0.11590734 0.111246698 0.07120651 0.06655532 3 vs 4 HI_CHOL 0.073826228 race NaN agecat 0.103902581 RIAGENDR 0.004645715 exp(coef) [confint] p trt 1.03 [0.72, 1.47] 0.891 age 1.03 [1.01, 1.05] 0.005 albumin 0.26 [0.17, 0.41] <0.001 ascites 2.93 [1.68, 5.11] <0.001 exp(coef) [confint] p trt 1.03 [0.72, 1.47] 0.891 age 1.03 [1.01, 1.05] 0.005 albumin 0.26 [0.17, 0.41] <0.001 ascites 2.93 [1.68, 5.11] <0.001 exp(coef) [confint] p (Intercept) 4.81558 [0.26099, 93.77267] 0.293 trt 1.05879 [0.63994, 1.75622] 0.824 age 1.03850 [1.01306, 1.06547] 0.003 albumin 0.31078 [0.15316, 0.60752] 0.001 ascites 19.05020 [3.69390, 349.54310] 0.005 exp(coef) [confint] p (Intercept) 4.81558 [0.25650, 90.40912] 0.293 trt 1.05879 [0.63975, 1.75230] 0.824 age 1.03850 [1.01271, 1.06494] 0.003 albumin 0.31078 [0.15640, 0.61757] 0.001 ascites 19.05020 [2.44625, 148.35373] 0.005 coef [confint] p (Intercept) -1194.06334 [-2499.63435, 111.50767] 0.073 trt -50.39655 [-275.96185, 175.16874] 0.661 age -2.97371 [-14.01246, 8.06504] 0.596 albumin 987.37770 [695.98678, 1278.76862] <0.001 ascites -664.69235 [-1126.85877, -202.52592] 0.005 coef [confint] p (Intercept) -1194.06334 [-2494.48743, 106.36074] 0.073 trt -50.39655 [-275.07261, 174.27950] 0.661 age -2.97371 [-13.96894, 8.02152] 0.596 albumin 987.37770 [697.13553, 1277.61988] <0.001 ascites -664.69235 [-1125.03679, -204.34791] 0.005 exp(coef) [confint] p (Intercept) 2.82698 [2.64169, 3.02526] <0.001 trt 0.82689 [0.75758, 0.90254] <0.001 day 0.96758 [0.96225, 0.97295] <0.001 coef [confint] p (Intercept) 2.70219 [2.51140, 2.89298] <0.001 trt -0.36806 [-0.57681, -0.15930] 0.001 day -0.06464 [-0.07910, -0.05017] <0.001 ### The lme4 version is 1.1-26 coef [confint] p (Intercept) 2.70219 [2.51320, 2.89118] NA trt -0.36806 [-0.57306, -0.16305] NA day -0.06464 [-0.07905, -0.05022] NA coef [confint] p (Intercept) 2.70219 [2.51320, 2.89118] <0.001 trt -0.36806 [-0.57306, -0.16305] 0.001 day -0.06464 [-0.07905, -0.05022] <0.001 exp(coef) [confint] p (Intercept) 2.82371 [2.31045, 3.43231] <0.001 trt 0.82903 [0.70232, 0.97777] 0.026 day 0.96758 [0.94787, 0.98762] 0.002 ### Summary of continuous variables ### HI_CHOL: 0 RIAGENDR: 1 n miss p.miss mean sd median p25 p75 min max skew kurt race 3526 0 0 2 0.9 2 1 2 1 4 0.6 -0.3 ------------------------------------------------------------ HI_CHOL: 1 RIAGENDR: 1 n miss p.miss mean sd median p25 p75 min max skew kurt race 363 0 0 2 0.9 2 1 2 1 4 0.8 -0.1 ------------------------------------------------------------ HI_CHOL: 0 RIAGENDR: 2 n miss p.miss mean sd median p25 p75 min max skew kurt race 3533 0 0 2 0.9 2 1 2 1 4 0.6 -0.4 ------------------------------------------------------------ HI_CHOL: 1 RIAGENDR: 2 n miss p.miss mean sd median p25 p75 min max skew kurt race 424 0 0 2 0.8 2 1 2 1 4 0.7 0.6 p-values pNormal pNonNormal race 0.5071597 0.5761282 Standardize mean differences average 1 vs 2 1 vs 3 1 vs 4 2 vs 3 2 vs 4 race 0.04247045 0.03492105 0.0006074061 0.07524267 0.03396878 0.03638678 3 vs 4 race 0.073696 ======================================================================================= ### Summary of categorical variables ### HI_CHOL: 0 RIAGENDR: 1 var n miss p.miss level freq percent cum.percent agecat 3526 0 0.0 (0,19] 1119 31.7 31.7 (19,39] 797 22.6 54.3 (39,59] 775 22.0 76.3 (59,Inf] 835 23.7 100.0 ------------------------------------------------------------ HI_CHOL: 1 RIAGENDR: 1 var n miss p.miss level freq percent cum.percent agecat 363 0 0.0 (0,19] 10 2.8 2.8 (19,39] 88 24.2 27.0 (39,59] 173 47.7 74.7 (59,Inf] 92 25.3 100.0 ------------------------------------------------------------ HI_CHOL: 0 RIAGENDR: 2 var n miss p.miss level freq percent cum.percent agecat 3533 0 0.0 (0,19] 1015 28.7 28.7 (19,39] 950 26.9 55.6 (39,59] 796 22.5 78.1 (59,Inf] 772 21.9 100.0 ------------------------------------------------------------ HI_CHOL: 1 RIAGENDR: 2 var n miss p.miss level freq percent cum.percent agecat 424 0 0.0 (0,19] 6 1.4 1.4 (19,39] 70 16.5 17.9 (39,59] 167 39.4 57.3 (59,Inf] 181 42.7 100.0 p-values pApprox pExact agecat 9.387606e-89 NA Standardize mean differences average 1 vs 2 1 vs 3 1 vs 4 2 vs 3 2 vs 4 3 vs 4 agecat 0.702331 0.9040822 0.109801 0.985333 0.8536402 0.3838583 0.9772713 Stratified by HI_CHOL:RIAGENDR 0:1 1:1 0:2 1:2 p test n 3526 363 3533 424 race (mean (SD)) 1.98 (0.85) 1.95 (0.90) 1.98 (0.87) 1.92 (0.76) 0.507 Stratified by HI_CHOL:RIAGENDR 0:1 1:1 0:2 1:2 p n 3526 363 3533 424 race (mean (SD)) 1.98 (0.85) 1.95 (0.90) 1.98 (0.87) 1.92 (0.76) 0.507 agecat (%) <0.001 (0,19] 1119 (31.7) 10 ( 2.8) 1015 (28.7) 6 ( 1.4) (19,39] 797 (22.6) 88 (24.2) 950 (26.9) 70 (16.5) (39,59] 775 (22.0) 173 (47.7) 796 (22.5) 167 (39.4) (59,Inf] 835 (23.7) 92 (25.3) 772 (21.9) 181 (42.7) Stratified by HI_CHOL:RIAGENDR test SMD n race (mean (SD)) 0.042 agecat (%) 0.702 (0,19] (19,39] (39,59] (59,Inf] Error in solve.default(Vmat) : Lapack routine dgesv: system is exactly singular: U[4,4] = 0 Overall Missing n 450.01 E (mean (SD)) 2.00 (0.82) 0.0 C (mean (SD)) 2.13 (0.88) 0.0 Y = 1 (%) 177.0 (39.4) 0.2 C1 = 1 (%) 150.0 (33.3) 0.0 C2 (mean (SD)) 0.47 (0.50) 0.0 Overall Missing n 450.01 E (mean (SD)) 2.00 (0.82) 0.0 C (mean (SD)) 2.13 (0.88) 0.0 Y (%) 0.2 0 272.7 (60.6) 1 177.0 (39.3) NA 0.3 ( 0.1) C1 = 1 (%) 150.0 (33.3) 0.0 C2 (mean (SD)) 0.47 (0.50) 0.0 Stratified by E 1 2 3 p test n 150.01 150.00 150.00 E (mean (SD)) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) <0.001 C (mean (SD)) 2.13 (0.89) 2.13 (0.89) 2.13 (0.89) 1.000 Y = 1 (%) 59.0 (39.4) 59.0 (39.3) 59.0 (39.3) 1.000 C1 = 1 (%) 50.0 (33.3) 50.0 (33.3) 50.0 (33.3) 1.000 C2 (mean (SD)) 0.47 (0.50) 0.47 (0.50) 0.47 (0.50) 1.000 Stratified by E Missing n E (mean (SD)) 0.0 C (mean (SD)) 0.0 Y = 1 (%) 0.2 C1 = 1 (%) 0.0 C2 (mean (SD)) 0.0 Stratified by E:C1 1:0 2:0 3:0 1:1 n 100.01 100.00 100.00 50.00 E (mean (SD)) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) 1.00 (0.00) C (mean (SD)) 1.60 (0.49) 1.60 (0.49) 1.60 (0.49) 3.20 (0.40) Y = 1 (%) 22.0 (22.1) 22.0 (22.0) 22.0 (22.0) 37.0 ( 74.0) C1 = 1 (%) 0.0 ( 0.0) 0.0 ( 0.0) 0.0 ( 0.0) 50.0 (100.0) C2 (mean (SD)) 0.60 (0.49) 0.60 (0.49) 0.60 (0.49) 0.20 (0.40) Stratified by E:C1 2:1 3:1 p test Missing n 50.00 50.00 E (mean (SD)) 2.00 (0.00) 3.00 (0.00) <0.001 0.0 C (mean (SD)) 3.20 (0.40) 3.20 (0.40) <0.001 0.0 Y = 1 (%) 37.0 ( 74.0) 37.0 ( 74.0) <0.001 0.2 C1 = 1 (%) 50.0 (100.0) 50.0 (100.0) <0.001 0.0 C2 (mean (SD)) 0.20 (0.40) 0.20 (0.40) <0.001 0.0 Stratified by E Overall 1 2 3 n 450.01 150.01 150.00 150.00 E (mean (SD)) 2.00 (0.82) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) C (mean (SD)) 2.13 (0.88) 2.13 (0.89) 2.13 (0.89) 2.13 (0.89) Y = 1 (%) 177.0 (39.4) 59.0 (39.4) 59.0 (39.3) 59.0 (39.3) C1 = 1 (%) 150.0 (33.3) 50.0 (33.3) 50.0 (33.3) 50.0 (33.3) C2 (mean (SD)) 0.47 (0.50) 0.47 (0.50) 0.47 (0.50) 0.47 (0.50) Stratified by E p test Missing n E (mean (SD)) <0.001 0.0 C (mean (SD)) 1.000 0.0 Y = 1 (%) 1.000 0.2 C1 = 1 (%) 1.000 0.0 C2 (mean (SD)) 1.000 0.0 Stratified by E:C1 Overall 1:0 2:0 3:0 n 450.01 100.01 100.00 100.00 E (mean (SD)) 2.00 (0.82) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) C (mean (SD)) 2.13 (0.88) 1.60 (0.49) 1.60 (0.49) 1.60 (0.49) Y = 1 (%) 177.0 (39.4) 22.0 (22.1) 22.0 (22.0) 22.0 (22.0) C1 = 1 (%) 150.0 (33.3) 0.0 ( 0.0) 0.0 ( 0.0) 0.0 ( 0.0) C2 (mean (SD)) 0.47 (0.50) 0.60 (0.49) 0.60 (0.49) 0.60 (0.49) Stratified by E:C1 1:1 2:1 3:1 p test n 50.00 50.00 50.00 E (mean (SD)) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) <0.001 C (mean (SD)) 3.20 (0.40) 3.20 (0.40) 3.20 (0.40) <0.001 Y = 1 (%) 37.0 ( 74.0) 37.0 ( 74.0) 37.0 ( 74.0) <0.001 C1 = 1 (%) 50.0 (100.0) 50.0 (100.0) 50.0 (100.0) <0.001 C2 (mean (SD)) 0.20 (0.40) 0.20 (0.40) 0.20 (0.40) <0.001 Stratified by E:C1 Missing n E (mean (SD)) 0.0 C (mean (SD)) 0.0 Y = 1 (%) 0.2 C1 = 1 (%) 0.0 C2 (mean (SD)) 0.0 Stratified by E 1 2 3 p test n 150.01 150.00 150.00 E (mean (SD)) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) <0.001 C (mean (SD)) 2.13 (0.89) 2.13 (0.89) 2.13 (0.89) 1.000 Y = 1 (%) 59.0 (39.4) 59.0 (39.3) 59.0 (39.3) 1.000 C1 = 1 (%) 50.0 (33.3) 50.0 (33.3) 50.0 (33.3) 1.000 C2 (mean (SD)) 0.47 (0.50) 0.47 (0.50) 0.47 (0.50) 1.000 Stratified by E 1 2 3 p test n 150.01 150.00 150.00 E (mean (SD)) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) <0.001 C (mean (SD)) 2.13 (0.89) 2.13 (0.89) 2.13 (0.89) 1.000 Y = 1 (%) 59.0 (39.4) 59.0 (39.3) 59.0 (39.3) 1.000 C1 = 1 (%) 50.0 (33.3) 50.0 (33.3) 50.0 (33.3) 1.000 C2 (mean (SD)) 0.47 (0.50) 0.47 (0.50) 0.47 (0.50) 1.000 Overall n 450.01 E (mean (SD)) 2.00 (0.82) C (mean (SD)) 2.13 (0.88) Y = 1 (%) 177.0 (39.4) C1 = 1 (%) 150.0 (33.3) C2 (mean (SD)) 0.47 (0.50) Overall n 450.01 E (mean (SD)) 2.00 (0.82) C (mean (SD)) 2.13 (0.88) Y = 1 (%) 177.0 (39.4) C1 = 1 (%) 150.0 (33.3) C2 (mean (SD)) 0.47 (0.50) Overall n 450.01 E (mean (SD)) 2.00 (0.82) C (mean (SD)) 2.13 (0.88) Y (%) 0 272.7 (60.6) 1 177.0 (39.3) NA 0.3 ( 0.1) C1 = 1 (%) 150.0 (33.3) C2 (mean (SD)) 0.47 (0.50) Overall n 450.01 E (mean (SD)) 2.00 (0.82) C (mean (SD)) 2.13 (0.88) Y (%) 0 272.7 (60.6) 1 177.0 (39.3) NA 0.3 ( 0.1) C1 = 1 (%) 150.0 (33.3) C2 (mean (SD)) 0.47 (0.50) Stratified by E:C1 1:0 2:0 3:0 1:1 n 100.01 100.00 100.00 50.00 E (mean (SD)) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) 1.00 (0.00) C (mean (SD)) 1.60 (0.49) 1.60 (0.49) 1.60 (0.49) 3.20 (0.40) Y = 1 (%) 22.0 (22.1) 22.0 (22.0) 22.0 (22.0) 37.0 ( 74.0) C1 = 1 (%) 0.0 ( 0.0) 0.0 ( 0.0) 0.0 ( 0.0) 50.0 (100.0) C2 (mean (SD)) 0.60 (0.49) 0.60 (0.49) 0.60 (0.49) 0.20 (0.40) Stratified by E:C1 2:1 3:1 p test n 50.00 50.00 E (mean (SD)) 2.00 (0.00) 3.00 (0.00) <0.001 C (mean (SD)) 3.20 (0.40) 3.20 (0.40) <0.001 Y = 1 (%) 37.0 ( 74.0) 37.0 ( 74.0) <0.001 C1 = 1 (%) 50.0 (100.0) 50.0 (100.0) <0.001 C2 (mean (SD)) 0.20 (0.40) 0.20 (0.40) <0.001 Stratified by E:C1 1:0 2:0 3:0 1:1 n 100.01 100.00 100.00 50.00 E (mean (SD)) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) 1.00 (0.00) C (mean (SD)) 1.60 (0.49) 1.60 (0.49) 1.60 (0.49) 3.20 (0.40) Y = 1 (%) 22.0 (22.1) 22.0 (22.0) 22.0 (22.0) 37.0 ( 74.0) C1 = 1 (%) 0.0 ( 0.0) 0.0 ( 0.0) 0.0 ( 0.0) 50.0 (100.0) C2 (mean (SD)) 0.60 (0.49) 0.60 (0.49) 0.60 (0.49) 0.20 (0.40) Stratified by E:C1 2:1 3:1 p test n 50.00 50.00 E (mean (SD)) 2.00 (0.00) 3.00 (0.00) <0.001 C (mean (SD)) 3.20 (0.40) 3.20 (0.40) <0.001 Y = 1 (%) 37.0 ( 74.0) 37.0 ( 74.0) <0.001 C1 = 1 (%) 50.0 (100.0) 50.0 (100.0) <0.001 C2 (mean (SD)) 0.20 (0.40) 0.20 (0.40) <0.001 Stratified by E 1 2 3 n 150.0120 150.0030 150.0000 E (mean (SD)) 1.0000 (0.0000) 2.0000 (0.0000) 3.0000 (0.0000) C (mean (SD)) 2.1332 (0.8854) 2.1333 (0.8861) 2.1333 (0.8861) Y = 1 (%) 59.001 (39.406) 59.001 (39.333) 59.000 (39.333) C1 = 1 (%) 50.000 (33.331) 50.000 (33.333) 50.000 (33.333) C2 (mean (SD)) 0.4666 (0.4994) 0.4667 (0.4999) 0.4667 (0.4998) Stratified by E p test n E (mean (SD)) <0.00001 C (mean (SD)) 1.00000 Y = 1 (%) 0.99982 C1 = 1 (%) 1.00000 C2 (mean (SD)) 1.00000 Stratified by E 1 2 3 n 150.0120 150.0030 150.0000 E (mean (SD)) 1.0000 (0.0000) 2.0000 (0.0000) 3.0000 (0.0000) C (mean (SD)) 2.1332 (0.8854) 2.1333 (0.8861) 2.1333 (0.8861) Y = 1 (%) 59.001 (39.406) 59.001 (39.333) 59.000 (39.333) C1 = 1 (%) 50.000 (33.331) 50.000 (33.333) 50.000 (33.333) C2 (mean (SD)) 0.4666 (0.4994) 0.4667 (0.4999) 0.4667 (0.4998) Stratified by E p test n E (mean (SD)) <0.00001 C (mean (SD)) 1.00000 Y = 1 (%) 0.99982 C1 = 1 (%) 1.00000 C2 (mean (SD)) 1.00000 Stratified by E 1 2 3 n 150.01 150.00 150.00 E (mean (SD)) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) C (mean (SD)) 2.13 (0.89) 2.13 (0.89) 2.13 (0.89) Y = 1 (%) 59.0 (39.4) 59.0 (39.3) 59.0 (39.3) C1 = 1 (%) 50.0 (33.3) 50.0 (33.3) 50.0 (33.3) C2 (mean (SD)) 0.47 (0.50) 0.47 (0.50) 0.47 (0.50) Stratified by E 1 2 3 n 150.01 150.00 150.00 E (mean (SD)) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) C (mean (SD)) 2.13 (0.89) 2.13 (0.89) 2.13 (0.89) Y = 1 (%) 59.0 (39.4) 59.0 (39.3) 59.0 (39.3) C1 = 1 (%) 50.0 (33.3) 50.0 (33.3) 50.0 (33.3) C2 (mean (SD)) 0.47 (0.50) 0.47 (0.50) 0.47 (0.50) Stratified by E 1 2 3 n 150.01 150.00 150.00 E (mean (SD)) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) C (median [IQR]) 2.00 [1.00, 3.00] 2.00 [1.00, 3.00] 2.00 [1.00, 3.00] Y = 1 (%) 59.0 (39.4) 59.0 (39.3) 59.0 (39.3) C1 = 1 (%) 50.0 (33.3) 50.0 (33.3) 50.0 (33.3) C2 (mean (SD)) 0.47 (0.50) 0.47 (0.50) 0.47 (0.50) Stratified by E p test n E (mean (SD)) <0.001 C (median [IQR]) 1.000 nonnorm Y = 1 (%) NA exact C1 = 1 (%) 1.000 C2 (mean (SD)) 1.000 Stratified by E 1 2 3 n 150.01 150.00 150.00 E (mean (SD)) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) C (median [IQR]) 2.00 [1.00, 3.00] 2.00 [1.00, 3.00] 2.00 [1.00, 3.00] Y = 1 (%) 59.0 (39.4) 59.0 (39.3) 59.0 (39.3) C1 = 1 (%) 50.0 (33.3) 50.0 (33.3) 50.0 (33.3) C2 (mean (SD)) 0.47 (0.50) 0.47 (0.50) 0.47 (0.50) Stratified by E p test n E (mean (SD)) <0.001 C (median [IQR]) 1.000 nonnorm Y = 1 (%) NA exact C1 = 1 (%) 1.000 C2 (mean (SD)) 1.000 Stratified by E 1 2 n 150.01 150.00 E (mean (SD)) 1.00 (0.00) 2.00 (0.00) C (median [range]) 2.00 [1.00, 4.00] 2.00 [1.00, 4.00] Y = 1 (%) 59.0 (39.4) 59.0 (39.3) C1 = 1 (%) 50.0 (33.3) 50.0 (33.3) C2 (mean (SD)) 0.47 (0.50) 0.47 (0.50) Stratified by E 3 p test n 150.00 E (mean (SD)) 3.00 (0.00) <0.001 C (median [range]) 2.00 [1.00, 4.00] 1.000 nonnorm Y = 1 (%) 59.0 (39.3) 1.000 C1 = 1 (%) 50.0 (33.3) 1.000 C2 (mean (SD)) 0.47 (0.50) 1.000 Stratified by E 1 2 n 150.01 150.00 E (mean (SD)) 1.00 (0.00) 2.00 (0.00) C (median [range]) 2.00 [1.00, 4.00] 2.00 [1.00, 4.00] Y = 1 (%) 59.0 (39.4) 59.0 (39.3) C1 = 1 (%) 50.0 (33.3) 50.0 (33.3) C2 (mean (SD)) 0.47 (0.50) 0.47 (0.50) Stratified by E 3 p test n 150.00 E (mean (SD)) 3.00 (0.00) <0.001 C (median [range]) 2.00 [1.00, 4.00] 1.000 nonnorm Y = 1 (%) 59.0 (39.3) 1.000 C1 = 1 (%) 50.0 (33.3) 1.000 C2 (mean (SD)) 0.47 (0.50) 1.000 Stratified by E 1 2 3 p test n 150.01 150.00 150.00 E (mean (SD)) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) <0.001 C (mean (SD)) 2.13 (0.89) 2.13 (0.89) 2.13 (0.89) 1.000 Y = 1 (%) 59.001 (39.406) 59.001 (39.333) 59.000 (39.333) 1.000 C1 = 1 (%) 50.000 (33.331) 50.000 (33.333) 50.000 (33.333) 1.000 C2 (mean (SD)) 0.47 (0.50) 0.47 (0.50) 0.47 (0.50) 1.000 Stratified by E 1 2 3 p test n 150.01 150.00 150.00 E (mean (SD)) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) <0.001 C (mean (SD)) 2.13 (0.89) 2.13 (0.89) 2.13 (0.89) 1.000 Y = 1 (%) 59.001 (39.406) 59.001 (39.333) 59.000 (39.333) 1.000 C1 = 1 (%) 50.000 (33.331) 50.000 (33.333) 50.000 (33.333) 1.000 C2 (mean (SD)) 0.47 (0.50) 0.47 (0.50) 0.47 (0.50) 1.000 Stratified by E level 1 2 n 150.01 150.00 E (mean (SD)) 1.00 (0.00) 2.00 (0.00) C (median [IQR]) 2.00 [1.00, 3.00] 2.00 [1.00, 3.00] Y (%) 0 90.7 (60.6) 91.0 (60.7) 1 59.0 (39.4) 59.0 (39.3) C1 (%) 0 100.0 (66.7) 100.0 (66.7) 1 50.0 (33.3) 50.0 (33.3) C2 (mean (SD)) 0.47 (0.50) 0.47 (0.50) Stratified by E 3 p test n 150.00 E (mean (SD)) 3.00 (0.00) <0.001 C (median [IQR]) 2.00 [1.00, 3.00] 1.000 nonnorm Y (%) 91.0 (60.7) NA exact 59.0 (39.3) C1 (%) 100.0 (66.7) 1.000 50.0 (33.3) C2 (mean (SD)) 0.47 (0.50) 1.000 Stratified by E level 1 2 n 150.01 150.00 E (mean (SD)) 1.00 (0.00) 2.00 (0.00) C (median [IQR]) 2.00 [1.00, 3.00] 2.00 [1.00, 3.00] Y (%) 0 90.7 (60.6) 91.0 (60.7) 1 59.0 (39.4) 59.0 (39.3) C1 (%) 0 100.0 (66.7) 100.0 (66.7) 1 50.0 (33.3) 50.0 (33.3) C2 (mean (SD)) 0.47 (0.50) 0.47 (0.50) Stratified by E 3 p test n 150.00 E (mean (SD)) 3.00 (0.00) <0.001 C (median [IQR]) 2.00 [1.00, 3.00] 1.000 nonnorm Y (%) 91.0 (60.7) NA exact 59.0 (39.3) C1 (%) 100.0 (66.7) 1.000 50.0 (33.3) C2 (mean (SD)) 0.47 (0.50) 1.000 "Stratified by E" "" "1" "2" "n" "150.01" "150.00" "E (mean (SD))" "1.00 (0.00)" "2.00 (0.00)" "C (median [IQR])" "2.00 [1.00, 3.00]" "2.00 [1.00, 3.00]" "Y = 1 (%)" "59.001 (39.406)" "59.001 (39.333)" "C1 = 1 (%)" "50.000 (33.331)" "50.000 (33.333)" "C2 (mean (SD))" "0.47 (0.50)" "0.47 (0.50)" "Stratified by E" "" "3" "p" "test" "n" "150.00" "" "" "E (mean (SD))" "3.00 (0.00)" "<0.001" "" "C (median [IQR])" "2.00 [1.00, 3.00]" "1.000" "nonnorm" "Y = 1 (%)" "59.000 (39.333)" "NA" "exact" "C1 = 1 (%)" "50.000 (33.333)" "1.000" "" "C2 (mean (SD))" "0.47 (0.50)" "1.000" "" "Stratified by E" "" "1" "2" "n" "150.01" "150.00" "E (mean (SD))" "1.00 (0.00)" "2.00 (0.00)" "C (median [IQR])" "2.00 [1.00, 3.00]" "2.00 [1.00, 3.00]" "Y = 1 (%)" "59.001 (39.406)" "59.001 (39.333)" "C1 = 1 (%)" "50.000 (33.331)" "50.000 (33.333)" "C2 (mean (SD))" "0.47 (0.50)" "0.47 (0.50)" "Stratified by E" "" "3" "p" "test" "n" "150.00" "" "" "E (mean (SD))" "3.00 (0.00)" "<0.001" "" "C (median [IQR])" "2.00 [1.00, 3.00]" "1.000" "nonnorm" "Y = 1 (%)" "59.000 (39.333)" "NA" "exact" "C1 = 1 (%)" "50.000 (33.333)" "1.000" "" "C2 (mean (SD))" "0.47 (0.50)" "1.000" "" Stratified by E:C1 1:0 2:0 3:0 1:1 n 100.01 100.00 100.00 50.00 E (mean (SD)) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) 1.00 (0.00) C (mean (SD)) 1.60 (0.49) 1.60 (0.49) 1.60 (0.49) 3.20 (0.40) Stratified by E:C1 2:1 3:1 p test n 50.00 50.00 E (mean (SD)) 2.00 (0.00) 3.00 (0.00) <0.001 C (mean (SD)) 3.20 (0.40) 3.20 (0.40) <0.001 Stratified by E:C1 1:0 2:0 3:0 1:1 n 100.01 100.00 100.00 50.00 E (mean (SD)) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) 1.00 (0.00) C (mean (SD)) 1.60 (0.49) 1.60 (0.49) 1.60 (0.49) 3.20 (0.40) Stratified by E:C1 2:1 3:1 p test n 50.00 50.00 E (mean (SD)) 2.00 (0.00) 3.00 (0.00) <0.001 C (mean (SD)) 3.20 (0.40) 3.20 (0.40) <0.001 Stratified by E:C1 1:0 2:0 3:0 1:1 n 100.0 100.0 100.0 50.0 Y = 1 (%) 22.0 (22.1) 22.0 (22.0) 22.0 (22.0) 37.0 ( 74.0) C1 = 1 (%) 0.0 ( 0.0) 0.0 ( 0.0) 0.0 ( 0.0) 50.0 (100.0) Stratified by E:C1 2:1 3:1 p test n 50.0 50.0 Y = 1 (%) 37.0 ( 74.0) 37.0 ( 74.0) <0.001 C1 = 1 (%) 50.0 (100.0) 50.0 (100.0) <0.001 Stratified by E:C1 1:0 2:0 3:0 1:1 n 100.0 100.0 100.0 50.0 Y = 1 (%) 22.0 (22.1) 22.0 (22.0) 22.0 (22.0) 37.0 ( 74.0) C1 = 1 (%) 0.0 ( 0.0) 0.0 ( 0.0) 0.0 ( 0.0) 50.0 (100.0) Stratified by E:C1 2:1 3:1 p test n 50.0 50.0 Y = 1 (%) 37.0 ( 74.0) 37.0 ( 74.0) <0.001 C1 = 1 (%) 50.0 (100.0) 50.0 (100.0) <0.001 Stratified by E Overall 1 2 3 n 450.01 150.01 150.00 150.00 E (mean (SD)) 2.00 (0.82) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) C (mean (SD)) 2.13 (0.88) 2.13 (0.89) 2.13 (0.89) 2.13 (0.89) Y = 1 (%) 177.0 (39.4) 59.0 (39.4) 59.0 (39.3) 59.0 (39.3) C1 = 1 (%) 150.0 (33.3) 50.0 (33.3) 50.0 (33.3) 50.0 (33.3) C2 (mean (SD)) 0.47 (0.50) 0.47 (0.50) 0.47 (0.50) 0.47 (0.50) Stratified by E p test SMD n E (mean (SD)) <0.001 Inf C (mean (SD)) 1.000 <0.001 Y = 1 (%) 1.000 0.001 C1 = 1 (%) 1.000 <0.001 C2 (mean (SD)) 1.000 <0.001 Stratified by E Overall 1 2 3 n 450.01 150.01 150.00 150.00 E (mean (SD)) 2.00 (0.82) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) C (mean (SD)) 2.13 (0.88) 2.13 (0.89) 2.13 (0.89) 2.13 (0.89) Y = 1 (%) 177.0 (39.4) 59.0 (39.4) 59.0 (39.3) 59.0 (39.3) C1 = 1 (%) 150.0 (33.3) 50.0 (33.3) 50.0 (33.3) 50.0 (33.3) C2 (mean (SD)) 0.47 (0.50) 0.47 (0.50) 0.47 (0.50) 0.47 (0.50) Stratified by E p test SMD n E (mean (SD)) <0.001 Inf C (mean (SD)) 1.000 <0.001 Y = 1 (%) 1.000 0.001 C1 = 1 (%) 1.000 <0.001 C2 (mean (SD)) 1.000 <0.001 Stratified by E:C1 Overall 1:0 2:0 3:0 n 450.01 100.01 100.00 100.00 E (mean (SD)) 2.00 (0.82) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) C (mean (SD)) 2.13 (0.88) 1.60 (0.49) 1.60 (0.49) 1.60 (0.49) Y = 1 (%) 177.0 (39.4) 22.0 (22.1) 22.0 (22.0) 22.0 (22.0) C1 = 1 (%) 150.0 (33.3) 0.0 ( 0.0) 0.0 ( 0.0) 0.0 ( 0.0) C2 (mean (SD)) 0.47 (0.50) 0.60 (0.49) 0.60 (0.49) 0.60 (0.49) Stratified by E:C1 1:1 2:1 3:1 p test n 50.00 50.00 50.00 E (mean (SD)) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) <0.001 C (mean (SD)) 3.20 (0.40) 3.20 (0.40) 3.20 (0.40) <0.001 Y = 1 (%) 37.0 ( 74.0) 37.0 ( 74.0) 37.0 ( 74.0) <0.001 C1 = 1 (%) 50.0 (100.0) 50.0 (100.0) 50.0 (100.0) <0.001 C2 (mean (SD)) 0.20 (0.40) 0.20 (0.40) 0.20 (0.40) <0.001 Stratified by E:C1 SMD n E (mean (SD)) Inf C (mean (SD)) 2.137 Y = 1 (%) 0.731 C1 = 1 (%) NaN C2 (mean (SD)) 0.534 Stratified by E:C1 Overall 1:0 2:0 3:0 n 450.01 100.01 100.00 100.00 E (mean (SD)) 2.00 (0.82) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) C (mean (SD)) 2.13 (0.88) 1.60 (0.49) 1.60 (0.49) 1.60 (0.49) Y = 1 (%) 177.0 (39.4) 22.0 (22.1) 22.0 (22.0) 22.0 (22.0) C1 = 1 (%) 150.0 (33.3) 0.0 ( 0.0) 0.0 ( 0.0) 0.0 ( 0.0) C2 (mean (SD)) 0.47 (0.50) 0.60 (0.49) 0.60 (0.49) 0.60 (0.49) Stratified by E:C1 1:1 2:1 3:1 p test n 50.00 50.00 50.00 E (mean (SD)) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) <0.001 C (mean (SD)) 3.20 (0.40) 3.20 (0.40) 3.20 (0.40) <0.001 Y = 1 (%) 37.0 ( 74.0) 37.0 ( 74.0) 37.0 ( 74.0) <0.001 C1 = 1 (%) 50.0 (100.0) 50.0 (100.0) 50.0 (100.0) <0.001 C2 (mean (SD)) 0.20 (0.40) 0.20 (0.40) 0.20 (0.40) <0.001 Stratified by E:C1 SMD n E (mean (SD)) Inf C (mean (SD)) 2.137 Y = 1 (%) 0.731 C1 = 1 (%) NaN C2 (mean (SD)) 0.534 Stratified by E Overall 1 2 n 4,50D01 1,50D01 1,50D00 E (mean (SD)) 2D00 (0D82) 1D00 (0D00) 2D00 (0D00) C (mean (SD)) 2D13 (0D88) 2D13 (0D89) 2D13 (0D89) Y = 1 (%) 1,77D0 (39D4) 59D0 (39D4) 59D0 (39D3) C1 = 1 (%) 1,50D0 (33D3) 50D0 (33D3) 50D0 (33D3) C2 (mean (SD)) 0D47 (0D50) 0D47 (0D50) 0D47 (0D50) Stratified by E 3 p test SMD n 1,50D00 E (mean (SD)) 3D00 (0D00) <0D001 Inf C (mean (SD)) 2D13 (0D89) 1D000 <0D001 Y = 1 (%) 59D0 (39D3) 1D000 0D001 C1 = 1 (%) 50D0 (33D3) 1D000 <0D001 C2 (mean (SD)) 0D47 (0D50) 1D000 <0D001 Stratified by E Overall 1 2 n 4,50D01 1,50D01 1,50D00 E (mean (SD)) 2D00 (0D82) 1D00 (0D00) 2D00 (0D00) C (mean (SD)) 2D13 (0D88) 2D13 (0D89) 2D13 (0D89) Y = 1 (%) 1,77D0 (39D4) 59D0 (39D4) 59D0 (39D3) C1 = 1 (%) 1,50D0 (33D3) 50D0 (33D3) 50D0 (33D3) C2 (mean (SD)) 0D47 (0D50) 0D47 (0D50) 0D47 (0D50) Stratified by E 3 p test SMD n 1,50D00 E (mean (SD)) 3D00 (0D00) <0D001 Inf C (mean (SD)) 2D13 (0D89) 1D000 <0D001 Y = 1 (%) 59D0 (39D3) 1D000 0D001 C1 = 1 (%) 50D0 (33D3) 1D000 <0D001 C2 (mean (SD)) 0D47 (0D50) 1D000 <0D001 Stratified by E:C1 Overall 1:0 2:0 n 4,50D01 1,00D01 1,00D00 E (mean (SD)) 2D00 (0D82) 1D00 (0D00) 2D00 (0D00) C (mean (SD)) 2D13 (0D88) 1D60 (0D49) 1D60 (0D49) Y = 1 (%) 1,77D0 (39D4) 22D0 (22D1) 22D0 (22D0) C1 = 1 (%) 1,50D0 (33D3) 0D0 ( 0D0) 0D0 ( 0D0) C2 (mean (SD)) 0D47 (0D50) 0D60 (0D49) 0D60 (0D49) Stratified by E:C1 3:0 1:1 2:1 n 1,00D00 50D00 50D00 E (mean (SD)) 3D00 (0D00) 1D00 (0D00) 2D00 (0D00) C (mean (SD)) 1D60 (0D49) 3D20 (0D40) 3D20 (0D40) Y = 1 (%) 22D0 (22D0) 37D0 ( 74D0) 37D0 ( 74D0) C1 = 1 (%) 0D0 ( 0D0) 50D0 (1,00D0) 50D0 (1,00D0) C2 (mean (SD)) 0D60 (0D49) 0D20 (0D40) 0D20 (0D40) Stratified by E:C1 3:1 p test SMD n 50D00 E (mean (SD)) 3D00 (0D00) <0D001 Inf C (mean (SD)) 3D20 (0D40) <0D001 2D137 Y = 1 (%) 37D0 ( 74D0) <0D001 0D731 C1 = 1 (%) 50D0 (1,00D0) <0D001 NaN C2 (mean (SD)) 0D20 (0D40) <0D001 0D534 Stratified by E:C1 Overall 1:0 2:0 n 4,50D01 1,00D01 1,00D00 E (mean (SD)) 2D00 (0D82) 1D00 (0D00) 2D00 (0D00) C (mean (SD)) 2D13 (0D88) 1D60 (0D49) 1D60 (0D49) Y = 1 (%) 1,77D0 (39D4) 22D0 (22D1) 22D0 (22D0) C1 = 1 (%) 1,50D0 (33D3) 0D0 ( 0D0) 0D0 ( 0D0) C2 (mean (SD)) 0D47 (0D50) 0D60 (0D49) 0D60 (0D49) Stratified by E:C1 3:0 1:1 2:1 n 1,00D00 50D00 50D00 E (mean (SD)) 3D00 (0D00) 1D00 (0D00) 2D00 (0D00) C (mean (SD)) 1D60 (0D49) 3D20 (0D40) 3D20 (0D40) Y = 1 (%) 22D0 (22D0) 37D0 ( 74D0) 37D0 ( 74D0) C1 = 1 (%) 0D0 ( 0D0) 50D0 (1,00D0) 50D0 (1,00D0) C2 (mean (SD)) 0D60 (0D49) 0D20 (0D40) 0D20 (0D40) Stratified by E:C1 3:1 p test SMD n 50D00 E (mean (SD)) 3D00 (0D00) <0D001 Inf C (mean (SD)) 3D20 (0D40) <0D001 2D137 Y = 1 (%) 37D0 ( 74D0) <0D001 0D731 C1 = 1 (%) 50D0 (1,00D0) <0D001 NaN C2 (mean (SD)) 0D20 (0D40) <0D001 0D534 Stratified by E 1 2 3 p test n 150.0 150.0 150.0 Y = 1 (%) 59.0 (39.4) 59.0 (39.3) 59.0 (39.3) 1.000 C1 = 1 (%) 50.0 (33.3) 50.0 (33.3) 50.0 (33.3) 1.000 Stratified by E 1 2 3 p test n 150.0 150.0 150.0 Y = 1 (%) 59.0 (39.4) 59.0 (39.3) 59.0 (39.3) 1.000 C1 = 1 (%) 50.0 (33.3) 50.0 (33.3) 50.0 (33.3) 1.000 Stratified by Overall n 450.0 Y = 1 (%) 177.0 (39.4) C1 = 1 (%) 150.0 (33.3) Stratified by Overall n 450.0 Y = 1 (%) 177.0 (39.4) C1 = 1 (%) 150.0 (33.3) Stratified by Overall n 450.0 Y (%) 0 272.7 (60.6) 1 177.0 (39.3) NA 0.3 ( 0.1) C1 = 1 (%) 150.0 (33.3) Stratified by Overall n 450.0 Y (%) 0 272.7 (60.6) 1 177.0 (39.3) NA 0.3 ( 0.1) C1 = 1 (%) 150.0 (33.3) Stratified by E:C1 1:0 2:0 3:0 1:1 2:1 n 100.0 100.0 100.0 50.0 50.0 Y = 1 (%) 22.0 (22.1) 22.0 (22.0) 22.0 (22.0) 37.0 ( 74.0) 37.0 ( 74.0) C1 = 1 (%) 0.0 ( 0.0) 0.0 ( 0.0) 0.0 ( 0.0) 50.0 (100.0) 50.0 (100.0) Stratified by E:C1 3:1 p test n 50.0 Y = 1 (%) 37.0 ( 74.0) <0.001 C1 = 1 (%) 50.0 (100.0) <0.001 Stratified by E:C1 1:0 2:0 3:0 1:1 2:1 n 100.0 100.0 100.0 50.0 50.0 Y = 1 (%) 22.0 (22.1) 22.0 (22.0) 22.0 (22.0) 37.0 ( 74.0) 37.0 ( 74.0) C1 = 1 (%) 0.0 ( 0.0) 0.0 ( 0.0) 0.0 ( 0.0) 50.0 (100.0) 50.0 (100.0) Stratified by E:C1 3:1 p test n 50.0 Y = 1 (%) 37.0 ( 74.0) <0.001 C1 = 1 (%) 50.0 (100.0) <0.001 Stratified by E:C1 1:0 2:0 3:0 n 100.012 100.003 100.000 Y = 1 (%) 22.001 (22.062) 22.001 (22.000) 22.000 (22.000) C1 = 1 (%) 0.000 ( 0.000) 0.000 ( 0.000) 0.000 ( 0.000) Stratified by E:C1 1:1 2:1 3:1 p n 50.000 50.000 50.000 Y = 1 (%) 37.000 ( 74.000) 37.000 ( 74.000) 37.000 ( 74.000) <0.00001 C1 = 1 (%) 50.000 (100.000) 50.000 (100.000) 50.000 (100.000) <0.00001 Stratified by E:C1 test n Y = 1 (%) C1 = 1 (%) Stratified by E:C1 1:0 2:0 3:0 n 100.012 100.003 100.000 Y = 1 (%) 22.001 (22.062) 22.001 (22.000) 22.000 (22.000) C1 = 1 (%) 0.000 ( 0.000) 0.000 ( 0.000) 0.000 ( 0.000) Stratified by E:C1 1:1 2:1 3:1 p n 50.000 50.000 50.000 Y = 1 (%) 37.000 ( 74.000) 37.000 ( 74.000) 37.000 ( 74.000) <0.00001 C1 = 1 (%) 50.000 (100.000) 50.000 (100.000) 50.000 (100.000) <0.00001 Stratified by E:C1 test n Y = 1 (%) C1 = 1 (%) Stratified by E:C1 1:0 2:0 3:0 1:1 2:1 n 100.0 100.0 100.0 50.0 50.0 Y = 1 (%) 22.0 (22.1) 22.0 (22.0) 22.0 (22.0) 37.0 ( 74.0) 37.0 ( 74.0) C1 = 1 (%) 0.0 ( 0.0) 0.0 ( 0.0) 0.0 ( 0.0) 50.0 (100.0) 50.0 (100.0) Stratified by E:C1 3:1 n 50.0 Y = 1 (%) 37.0 ( 74.0) C1 = 1 (%) 50.0 (100.0) Stratified by E:C1 1:0 2:0 3:0 1:1 2:1 n 100.0 100.0 100.0 50.0 50.0 Y = 1 (%) 22.0 (22.1) 22.0 (22.0) 22.0 (22.0) 37.0 ( 74.0) 37.0 ( 74.0) C1 = 1 (%) 0.0 ( 0.0) 0.0 ( 0.0) 0.0 ( 0.0) 50.0 (100.0) 50.0 (100.0) Stratified by E:C1 3:1 n 50.0 Y = 1 (%) 37.0 ( 74.0) C1 = 1 (%) 50.0 (100.0) Stratified by E 1 2 3 p test n 150.012 150.003 150.000 Y = 1 (%) 59.001 (39.406) 59.001 (39.333) 59.000 (39.333) 1.000 C1 = 1 (%) 50.000 (33.331) 50.000 (33.333) 50.000 (33.333) 1.000 Stratified by E 1 2 3 p test n 150.012 150.003 150.000 Y = 1 (%) 59.001 (39.406) 59.001 (39.333) 59.000 (39.333) 1.000 C1 = 1 (%) 50.000 (33.331) 50.000 (33.333) 50.000 (33.333) 1.000 Stratified by E level 1 2 3 p test n 150.0 150.0 150.0 Y (%) 0 90.7 (60.6) 91.0 (60.7) 91.0 (60.7) 1.000 1 59.0 (39.4) 59.0 (39.3) 59.0 (39.3) C1 (%) 0 100.0 (66.7) 100.0 (66.7) 100.0 (66.7) 1.000 1 50.0 (33.3) 50.0 (33.3) 50.0 (33.3) Stratified by E level 1 2 3 p test n 150.0 150.0 150.0 Y (%) 0 90.7 (60.6) 91.0 (60.7) 91.0 (60.7) 1.000 1 59.0 (39.4) 59.0 (39.3) 59.0 (39.3) C1 (%) 0 100.0 (66.7) 100.0 (66.7) 100.0 (66.7) 1.000 1 50.0 (33.3) 50.0 (33.3) 50.0 (33.3) Stratified by E 1 2 3 p test n 150.0 150.0 150.0 Y = 1 59.0 (39.4) 59.0 (39.3) 59.0 (39.3) 1.000 C1 = 1 50.0 (33.3) 50.0 (33.3) 50.0 (33.3) 1.000 Stratified by E 1 2 3 p test n 150.0 150.0 150.0 Y = 1 59.0 (39.4) 59.0 (39.3) 59.0 (39.3) 1.000 C1 = 1 50.0 (33.3) 50.0 (33.3) 50.0 (33.3) 1.000 Stratified by E 1 2 3 p test n 150.0 150.0 150.0 Y = 1 59.0 59.0 59.0 1.000 C1 = 1 50.0 50.0 50.0 1.000 Stratified by E 1 2 3 p test n 150.0 150.0 150.0 Y = 1 59.0 59.0 59.0 1.000 C1 = 1 50.0 50.0 50.0 1.000 Stratified by E 1 2 3 p test n 150.0 150.0 150.0 Y = 1 (%) 39.4 39.3 39.3 1.000 C1 = 1 (%) 33.3 33.3 33.3 1.000 Stratified by E 1 2 3 p test n 150.0 150.0 150.0 Y = 1 (%) 39.4 39.3 39.3 1.000 C1 = 1 (%) 33.3 33.3 33.3 1.000 Stratified by E 1 2 3 p test n 150.0 150.0 150.0 Y = 1 % (freq) 39.4 (59.0) 39.3 (59.0) 39.3 (59.0) 1.000 C1 = 1 % (freq) 33.3 (50.0) 33.3 (50.0) 33.3 (50.0) 1.000 Stratified by E 1 2 3 p test n 150.0 150.0 150.0 Y = 1 % (freq) 39.4 (59.0) 39.3 (59.0) 39.3 (59.0) 1.000 C1 = 1 % (freq) 33.3 (50.0) 33.3 (50.0) 33.3 (50.0) 1.000 Stratified by E 1 2 n 150.0 150.0 Y = 0/1 (%) 90.7/59.0 (60.6/39.4) 91.0/59.0 (60.7/39.3) C1 = 1 (%) 50.0 (33.3) 50.0 (33.3) Stratified by E 3 p test n 150.0 Y = 0/1 (%) 91.0/59.0 (60.7/39.3) 1.000 C1 = 1 (%) 50.0 (33.3) 1.000 Stratified by E 1 2 n 150.0 150.0 Y = 0/1 (%) 90.7/59.0 (60.6/39.4) 91.0/59.0 (60.7/39.3) C1 = 1 (%) 50.0 (33.3) 50.0 (33.3) Stratified by E 3 p test n 150.0 Y = 0/1 (%) 91.0/59.0 (60.7/39.3) 1.000 C1 = 1 (%) 50.0 (33.3) 1.000 "Stratified by E" "" "level" "1" "2" "3" "p" "test" "n" "" "150.0" "150.0" "150.0" "" "" "Y (%)" "0" "90.7 (60.6)" "91.0 (60.7)" "91.0 (60.7)" "1.000" "" "" "1" "59.0 (39.4)" "59.0 (39.3)" "59.0 (39.3)" "" "" "C1 (%)" "0" "100.0 (66.7)" "100.0 (66.7)" "100.0 (66.7)" "1.000" "" "" "1" "50.0 (33.3)" "50.0 (33.3)" "50.0 (33.3)" "" "" "Stratified by E" "" "level" "1" "2" "3" "p" "test" "n" "" "150.0" "150.0" "150.0" "" "" "Y (%)" "0" "90.7 (60.6)" "91.0 (60.7)" "91.0 (60.7)" "1.000" "" "" "1" "59.0 (39.4)" "59.0 (39.3)" "59.0 (39.3)" "" "" "C1 (%)" "0" "100.0 (66.7)" "100.0 (66.7)" "100.0 (66.7)" "1.000" "" "" "1" "50.0 (33.3)" "50.0 (33.3)" "50.0 (33.3)" "" "" Stratified by E Overall 1 2 3 p test n 450.0 150.0 150.0 150.0 Y = 1 (%) 177.0 (39.4) 59.0 (39.4) 59.0 (39.3) 59.0 (39.3) 1.000 C1 = 1 (%) 150.0 (33.3) 50.0 (33.3) 50.0 (33.3) 50.0 (33.3) 1.000 Stratified by E SMD n Y = 1 (%) 0.001 C1 = 1 (%) <0.001 Stratified by E Overall 1 2 3 p test n 450.0 150.0 150.0 150.0 Y = 1 (%) 177.0 (39.4) 59.0 (39.4) 59.0 (39.3) 59.0 (39.3) 1.000 C1 = 1 (%) 150.0 (33.3) 50.0 (33.3) 50.0 (33.3) 50.0 (33.3) 1.000 Stratified by E SMD n Y = 1 (%) 0.001 C1 = 1 (%) <0.001 Stratified by E:C1 Overall 1:0 2:0 3:0 1:1 n 450.0 100.0 100.0 100.0 50.0 Y = 1 (%) 177.0 (39.4) 22.0 (22.1) 22.0 (22.0) 22.0 (22.0) 37.0 ( 74.0) C1 = 1 (%) 150.0 (33.3) 0.0 ( 0.0) 0.0 ( 0.0) 0.0 ( 0.0) 50.0 (100.0) Stratified by E:C1 2:1 3:1 p test SMD n 50.0 50.0 Y = 1 (%) 37.0 ( 74.0) 37.0 ( 74.0) <0.001 0.731 C1 = 1 (%) 50.0 (100.0) 50.0 (100.0) <0.001 NaN Stratified by E:C1 Overall 1:0 2:0 3:0 1:1 n 450.0 100.0 100.0 100.0 50.0 Y = 1 (%) 177.0 (39.4) 22.0 (22.1) 22.0 (22.0) 22.0 (22.0) 37.0 ( 74.0) C1 = 1 (%) 150.0 (33.3) 0.0 ( 0.0) 0.0 ( 0.0) 0.0 ( 0.0) 50.0 (100.0) Stratified by E:C1 2:1 3:1 p test SMD n 50.0 50.0 Y = 1 (%) 37.0 ( 74.0) 37.0 ( 74.0) <0.001 0.731 C1 = 1 (%) 50.0 (100.0) 50.0 (100.0) <0.001 NaN Stratified by E:C1 1:0 2:0 3:0 1:1 2:1 n 100.0 100.0 100.0 50.0 50.0 Y = 1 (%) 22.0 (22.1) 22.0 (22.0) 22.0 (22.0) 37.0 ( 74.0) 37.0 ( 74.0) C1 = 1 (%) 0.0 ( 0.0) 0.0 ( 0.0) 0.0 ( 0.0) 50.0 (100.0) 50.0 (100.0) Stratified by E:C1 3:1 p test n 50.0 Y = 1 (%) 37.0 ( 74.0) <0.001 C1 = 1 (%) 50.0 (100.0) <0.001 Cell Contents |-------------------------| | N | | Chi-square contribution | | N / Row Total | | N / Col Total | | N / Table Total | |-------------------------| Total Observations in Table: 449.7292 | E:C1 Y | 1:0 | 2:0 | 3:0 | 1:1 | 2:1 | 3:1 | Row Total | -------------|-----------|-----------|-----------|-----------|-----------|-----------|-----------| 0 | 77 | 78 | 78 | 13 | 13 | 13 | 272 | | 4.919 | 4.968 | 4.968 | 9.895 | 9.895 | 9.895 | | | 0.285 | 0.286 | 0.286 | 0.048 | 0.048 | 0.048 | 0.606 | | 0.779 | 0.780 | 0.780 | 0.260 | 0.260 | 0.260 | | | 0.173 | 0.173 | 0.173 | 0.029 | 0.029 | 0.029 | | -------------|-----------|-----------|-----------|-----------|-----------|-----------|-----------| 1 | 22 | 22 | 22 | 37 | 37 | 37 | 177 | | 7.580 | 7.655 | 7.655 | 15.246 | 15.246 | 15.246 | | | 0.124 | 0.124 | 0.124 | 0.209 | 0.209 | 0.209 | 0.394 | | 0.221 | 0.220 | 0.220 | 0.740 | 0.740 | 0.740 | | | 0.049 | 0.049 | 0.049 | 0.082 | 0.082 | 0.082 | | -------------|-----------|-----------|-----------|-----------|-----------|-----------|-----------| Column Total | 99 | 100 | 100 | 50 | 50 | 50 | 449 | | 0.222 | 0.222 | 0.222 | 0.111 | 0.111 | 0.111 | | -------------|-----------|-----------|-----------|-----------|-----------|-----------|-----------| Cell Contents |-------------------------| | N | | Chi-square contribution | | N / Row Total | | N / Col Total | | N / Table Total | |-------------------------| Total Observations in Table: 450.015 | E:C1 C1 | 1:0 | 2:0 | 3:0 | 1:1 | 2:1 | 3:1 | Row Total | -------------|-----------|-----------|-----------|-----------|-----------|-----------|-----------| 0 | 100 | 100 | 100 | 0 | 0 | 0 | 300 | | 16.667 | 16.666 | 16.665 | 33.334 | 33.334 | 33.334 | | | 0.333 | 0.333 | 0.333 | 0.000 | 0.000 | 0.000 | 0.667 | | 1.000 | 1.000 | 1.000 | 0.000 | 0.000 | 0.000 | | | 0.222 | 0.222 | 0.222 | 0.000 | 0.000 | 0.000 | | -------------|-----------|-----------|-----------|-----------|-----------|-----------|-----------| 1 | 0 | 0 | 0 | 50 | 50 | 50 | 150 | | 33.336 | 33.333 | 33.332 | 66.671 | 66.671 | 66.671 | | | 0.000 | 0.000 | 0.000 | 0.333 | 0.333 | 0.333 | 0.333 | | 0.000 | 0.000 | 0.000 | 1.000 | 1.000 | 1.000 | | | 0.000 | 0.000 | 0.000 | 0.111 | 0.111 | 0.111 | | -------------|-----------|-----------|-----------|-----------|-----------|-----------|-----------| Column Total | 100 | 100 | 100 | 50 | 50 | 50 | 450 | | 0.222 | 0.222 | 0.222 | 0.111 | 0.111 | 0.111 | | -------------|-----------|-----------|-----------|-----------|-----------|-----------|-----------| Stratified by E 1 2 3 p test n 150.01 150.00 150.00 E (mean (SD)) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) <0.001 C (mean (SD)) 2.13 (0.89) 2.13 (0.89) 2.13 (0.89) 1.000 C2 (mean (SD)) 0.47 (0.50) 0.47 (0.50) 0.47 (0.50) 1.000 Stratified by E 1 2 3 p test n 150.01 150.00 150.00 E (mean (SD)) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) <0.001 C (mean (SD)) 2.13 (0.89) 2.13 (0.89) 2.13 (0.89) 1.000 C2 (mean (SD)) 0.47 (0.50) 0.47 (0.50) 0.47 (0.50) 1.000 Stratified by Overall n 450.01 E (mean (SD)) 2.00 (0.82) C (mean (SD)) 2.13 (0.88) C2 (mean (SD)) 0.47 (0.50) Stratified by Overall n 450.01 E (mean (SD)) 2.00 (0.82) C (mean (SD)) 2.13 (0.88) C2 (mean (SD)) 0.47 (0.50) Stratified by E:C1 1:0 2:0 3:0 1:1 2:1 n 100.01 100.00 100.00 50.00 50.00 E (mean (SD)) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) 1.00 (0.00) 2.00 (0.00) C (mean (SD)) 1.60 (0.49) 1.60 (0.49) 1.60 (0.49) 3.20 (0.40) 3.20 (0.40) C2 (mean (SD)) 0.60 (0.49) 0.60 (0.49) 0.60 (0.49) 0.20 (0.40) 0.20 (0.40) Stratified by E:C1 3:1 p test n 50.00 E (mean (SD)) 3.00 (0.00) <0.001 C (mean (SD)) 3.20 (0.40) <0.001 C2 (mean (SD)) 0.20 (0.40) <0.001 Stratified by E:C1 1:0 2:0 3:0 1:1 2:1 n 100.01 100.00 100.00 50.00 50.00 E (mean (SD)) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) 1.00 (0.00) 2.00 (0.00) C (mean (SD)) 1.60 (0.49) 1.60 (0.49) 1.60 (0.49) 3.20 (0.40) 3.20 (0.40) C2 (mean (SD)) 0.60 (0.49) 0.60 (0.49) 0.60 (0.49) 0.20 (0.40) 0.20 (0.40) Stratified by E:C1 3:1 p test n 50.00 E (mean (SD)) 3.00 (0.00) <0.001 C (mean (SD)) 3.20 (0.40) <0.001 C2 (mean (SD)) 0.20 (0.40) <0.001 Stratified by E 1 2 3 p test n 150.012 150.003 150.000 E (mean (SD)) 1.000 (0.000) 2.000 (0.000) 3.000 (0.000) <0.00001 C (mean (SD)) 2.133 (0.885) 2.133 (0.886) 2.133 (0.886) 1.00000 C2 (mean (SD)) 0.467 (0.499) 0.467 (0.500) 0.467 (0.500) 1.00000 Stratified by E 1 2 3 p test n 150.012 150.003 150.000 E (mean (SD)) 1.000 (0.000) 2.000 (0.000) 3.000 (0.000) <0.00001 C (mean (SD)) 2.133 (0.885) 2.133 (0.886) 2.133 (0.886) 1.00000 C2 (mean (SD)) 0.467 (0.499) 0.467 (0.500) 0.467 (0.500) 1.00000 Stratified by E 1 2 3 n 150.01 150.00 150.00 E (mean (SD)) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) C (mean (SD)) 2.13 (0.89) 2.13 (0.89) 2.13 (0.89) C2 (mean (SD)) 0.47 (0.50) 0.47 (0.50) 0.47 (0.50) Stratified by E 1 2 3 n 150.01 150.00 150.00 E (mean (SD)) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) C (mean (SD)) 2.13 (0.89) 2.13 (0.89) 2.13 (0.89) C2 (mean (SD)) 0.47 (0.50) 0.47 (0.50) 0.47 (0.50) Stratified by E 1 2 3 p n 150.01 150.00 150.00 E (mean (SD)) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) <0.001 C (median [IQR]) 2.00 [1.00, 3.00] 2.00 [1.00, 3.00] 2.00 [1.00, 3.00] 1.000 C2 (mean (SD)) 0.47 (0.50) 0.47 (0.50) 0.47 (0.50) 1.000 Stratified by E test n E (mean (SD)) C (median [IQR]) nonnorm C2 (mean (SD)) Stratified by E 1 2 3 p n 150.01 150.00 150.00 E (mean (SD)) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) <0.001 C (median [IQR]) 2.00 [1.00, 3.00] 2.00 [1.00, 3.00] 2.00 [1.00, 3.00] 1.000 C2 (mean (SD)) 0.47 (0.50) 0.47 (0.50) 0.47 (0.50) 1.000 Stratified by E test n E (mean (SD)) C (median [IQR]) nonnorm C2 (mean (SD)) Stratified by E 1 2 3 n 150.01 150.00 150.00 E (mean (SD)) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) C (median [range]) 2.00 [1.00, 4.00] 2.00 [1.00, 4.00] 2.00 [1.00, 4.00] C2 (mean (SD)) 0.47 (0.50) 0.47 (0.50) 0.47 (0.50) Stratified by E p test n E (mean (SD)) <0.001 C (median [range]) 1.000 nonnorm C2 (mean (SD)) 1.000 Stratified by E 1 2 3 n 150.01 150.00 150.00 E (mean (SD)) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) C (median [range]) 2.00 [1.00, 4.00] 2.00 [1.00, 4.00] 2.00 [1.00, 4.00] C2 (mean (SD)) 0.47 (0.50) 0.47 (0.50) 0.47 (0.50) Stratified by E p test n E (mean (SD)) <0.001 C (median [range]) 1.000 nonnorm C2 (mean (SD)) 1.000 Stratified by E 1 2 3 p test n 150.01 150.00 150.00 E (mean (SD)) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) <0.001 C (mean (SD)) 2.13 (0.89) 2.13 (0.89) 2.13 (0.89) 1.000 C2 (mean (SD)) 0.47 (0.50) 0.47 (0.50) 0.47 (0.50) 1.000 Stratified by E 1 2 3 p test n 150.01 150.00 150.00 E (mean (SD)) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) <0.001 C (mean (SD)) 2.13 (0.89) 2.13 (0.89) 2.13 (0.89) 1.000 C2 (mean (SD)) 0.47 (0.50) 0.47 (0.50) 0.47 (0.50) 1.000 Stratified by E 1 2 3 p test n 150.01 150.00 150.00 E 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) <0.001 C 2.13 (0.89) 2.13 (0.89) 2.13 (0.89) 1.000 C2 0.47 (0.50) 0.47 (0.50) 0.47 (0.50) 1.000 Stratified by E 1 2 3 p test n 150.01 150.00 150.00 E 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) <0.001 C 2.13 (0.89) 2.13 (0.89) 2.13 (0.89) 1.000 C2 0.47 (0.50) 0.47 (0.50) 0.47 (0.50) 1.000 "Stratified by E" "" "1" "2" "3" "p" "test" "n" "150.01" "150.00" "150.00" "" "" "E (mean (SD))" "1.00 (0.00)" "2.00 (0.00)" "3.00 (0.00)" "<0.001" "" "C (mean (SD))" "2.13 (0.89)" "2.13 (0.89)" "2.13 (0.89)" "1.000" "" "C2 (mean (SD))" "0.47 (0.50)" "0.47 (0.50)" "0.47 (0.50)" "1.000" "" "Stratified by E" "" "1" "2" "3" "p" "test" "n" "150.01" "150.00" "150.00" "" "" "E (mean (SD))" "1.00 (0.00)" "2.00 (0.00)" "3.00 (0.00)" "<0.001" "" "C (mean (SD))" "2.13 (0.89)" "2.13 (0.89)" "2.13 (0.89)" "1.000" "" "C2 (mean (SD))" "0.47 (0.50)" "0.47 (0.50)" "0.47 (0.50)" "1.000" "" Stratified by E Overall 1 2 3 p test n 450.01 150.01 150.00 150.00 E (mean (SD)) 2.00 (0.82) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) <0.001 C (mean (SD)) 2.13 (0.88) 2.13 (0.89) 2.13 (0.89) 2.13 (0.89) 1.000 C2 (mean (SD)) 0.47 (0.50) 0.47 (0.50) 0.47 (0.50) 0.47 (0.50) 1.000 Stratified by E SMD n E (mean (SD)) Inf C (mean (SD)) <0.001 C2 (mean (SD)) <0.001 Stratified by E Overall 1 2 3 p test n 450.01 150.01 150.00 150.00 E (mean (SD)) 2.00 (0.82) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) <0.001 C (mean (SD)) 2.13 (0.88) 2.13 (0.89) 2.13 (0.89) 2.13 (0.89) 1.000 C2 (mean (SD)) 0.47 (0.50) 0.47 (0.50) 0.47 (0.50) 0.47 (0.50) 1.000 Stratified by E SMD n E (mean (SD)) Inf C (mean (SD)) <0.001 C2 (mean (SD)) <0.001 Stratified by E:C1 Overall 1:0 2:0 3:0 1:1 n 450.01 100.01 100.00 100.00 50.00 E (mean (SD)) 2.00 (0.82) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) 1.00 (0.00) C (mean (SD)) 2.13 (0.88) 1.60 (0.49) 1.60 (0.49) 1.60 (0.49) 3.20 (0.40) C2 (mean (SD)) 0.47 (0.50) 0.60 (0.49) 0.60 (0.49) 0.60 (0.49) 0.20 (0.40) Stratified by E:C1 2:1 3:1 p test SMD n 50.00 50.00 E (mean (SD)) 2.00 (0.00) 3.00 (0.00) <0.001 Inf C (mean (SD)) 3.20 (0.40) 3.20 (0.40) <0.001 2.137 C2 (mean (SD)) 0.20 (0.40) 0.20 (0.40) <0.001 0.534 Stratified by E:C1 Overall 1:0 2:0 3:0 1:1 n 450.01 100.01 100.00 100.00 50.00 E (mean (SD)) 2.00 (0.82) 1.00 (0.00) 2.00 (0.00) 3.00 (0.00) 1.00 (0.00) C (mean (SD)) 2.13 (0.88) 1.60 (0.49) 1.60 (0.49) 1.60 (0.49) 3.20 (0.40) C2 (mean (SD)) 0.47 (0.50) 0.60 (0.49) 0.60 (0.49) 0.60 (0.49) 0.20 (0.40) Stratified by E:C1 2:1 3:1 p test SMD n 50.00 50.00 E (mean (SD)) 2.00 (0.00) 3.00 (0.00) <0.001 Inf C (mean (SD)) 3.20 (0.40) 3.20 (0.40) <0.001 2.137 C2 (mean (SD)) 0.20 (0.40) 0.20 (0.40) <0.001 0.534 Stratified by RIAGENDR 1 2 p test n 134944553.92 141591892.00 HI_CHOL (mean (SD)) 0.10 (0.30) 0.12 (0.33) 0.009 Stratified by RIAGENDR 1 2 p test n 134944553.92 141591892.00 HI_CHOL (mean (SD)) 0.10 (0.30) 0.12 (0.33) 0.009 Stratified by RIAGENDR 1 2 p test n 134944553.92 141591892.00 HI_CHOL (median [IQR]) 0.00 [0.00, 0.00] 0.00 [0.00, 0.00] 0.009 nonnorm Stratified by RIAGENDR 1 2 p test n 134944553.92 141591892.00 HI_CHOL (median [range]) 0.00 [0.00, 1.00] 0.00 [0.00, 1.00] 0.009 nonnorm Stratified by RIAGENDR 1 2 p test n 134944553.92 141591892.00 HI_CHOL (mean (SD)) 0.10 (0.30) 0.12 (0.33) 0.0092211 Stratified by RIAGENDR 1 2 p test n 134944553.92 141591892.00 HI_CHOL (median [IQR]) 0.00 [0.00, 0.00] 0.00 [0.00, 0.00] 0.0092211 nonnorm Stratified by RIAGENDR 1 2 p test n 134944553.923 141591891.998 race (%) 0.042 1 21381884.189 (15.845) 20251367.389 ( 14.303) 2 89315751.415 (66.187) 92486945.142 ( 65.319) 3 15045455.461 (11.149) 17967228.319 ( 12.689) 4 9201462.858 ( 6.819) 10886351.148 ( 7.689) agecat (%) 0.001 (0,19] 29299546.109 (21.712) 28150760.544 ( 19.882) (19,39] 40497613.070 (30.011) 40640361.534 ( 28.702) (39,59] 41053579.409 (30.423) 42817044.014 ( 30.240) (59,Inf] 24093815.335 (17.855) 29983725.904 ( 21.176) RIAGENDR = 2 (%) 0.000 ( 0.000) 141591891.998 (100.000) <0.001 Stratified by RIAGENDR 1 2 p test n 134944553.923 141591891.998 race (%) 0.042 1 21381884.189 (15.845) 20251367.389 ( 14.303) 2 89315751.415 (66.187) 92486945.142 ( 65.319) 3 15045455.461 (11.149) 17967228.319 ( 12.689) 4 9201462.858 ( 6.819) 10886351.148 ( 7.689) agecat (%) 0.001 (0,19] 29299546.109 (21.712) 28150760.544 ( 19.882) (19,39] 40497613.070 (30.011) 40640361.534 ( 28.702) (39,59] 41053579.409 (30.423) 42817044.014 ( 30.240) (59,Inf] 24093815.335 (17.855) 29983725.904 ( 21.176) RIAGENDR = 2 (%) 0.000 ( 0.000) 141591891.998 (100.000) <0.001 Stratified by RIAGENDR 1 2 p test n 134944553.9 141591892.0 race (%) 0.0416288 1 21381884.2 (15.8) 20251367.4 ( 14.3) 2 89315751.4 (66.2) 92486945.1 ( 65.3) 3 15045455.5 (11.1) 17967228.3 ( 12.7) 4 9201462.9 ( 6.8) 10886351.1 ( 7.7) agecat (%) 0.0011757 (0,19] 29299546.1 (21.7) 28150760.5 ( 19.9) (19,39] 40497613.1 (30.0) 40640361.5 ( 28.7) (39,59] 41053579.4 (30.4) 42817044.0 ( 30.2) (59,Inf] 24093815.3 (17.9) 29983725.9 ( 21.2) RIAGENDR = 2 (%) 0.0 ( 0.0) 141591892.0 (100.0) <0.0000001 Stratified by RIAGENDR 1 2 p n 134944553.92 141591892.00 HI_CHOL (mean (SD)) 0.10 (0.30) 0.12 (0.33) 0.0092211 race (%) 0.0416288 1 21381884.2 (15.8) 20251367.4 ( 14.3) 2 89315751.4 (66.2) 92486945.1 ( 65.3) 3 15045455.5 (11.1) 17967228.3 ( 12.7) 4 9201462.9 ( 6.8) 10886351.1 ( 7.7) agecat (%) 0.0011757 (0,19] 29299546.1 (21.7) 28150760.5 ( 19.9) (19,39] 40497613.1 (30.0) 40640361.5 ( 28.7) (39,59] 41053579.4 (30.4) 42817044.0 ( 30.2) (59,Inf] 24093815.3 (17.9) 29983725.9 ( 21.2) RIAGENDR = 2 (%) 0.0 ( 0.0) 141591892.0 (100.0) <0.0000001 Stratified by RIAGENDR test n HI_CHOL (mean (SD)) race (%) 1 2 3 4 agecat (%) (0,19] (19,39] (39,59] (59,Inf] RIAGENDR = 2 (%) Stratified by RIAGENDR 1 2 p n 134944553.92 141591892.00 HI_CHOL (mean (SD)) 0.10 (0.30) 0.12 (0.33) 0.0092211 race (%) 0.0416288 1 21381884.2 (15.8) 20251367.4 ( 14.3) 2 89315751.4 (66.2) 92486945.1 ( 65.3) 3 15045455.5 (11.1) 17967228.3 ( 12.7) 4 9201462.9 ( 6.8) 10886351.1 ( 7.7) agecat (%) 0.0011757 (0,19] 29299546.1 (21.7) 28150760.5 ( 19.9) (19,39] 40497613.1 (30.0) 40640361.5 ( 28.7) (39,59] 41053579.4 (30.4) 42817044.0 ( 30.2) (59,Inf] 24093815.3 (17.9) 29983725.9 ( 21.2) RIAGENDR = 2 (%) 0.0 ( 0.0) 141591892.0 (100.0) <0.0000001 Stratified by RIAGENDR test n HI_CHOL (mean (SD)) race (%) 1 2 3 4 agecat (%) (0,19] (19,39] (39,59] (59,Inf] RIAGENDR = 2 (%) Stratified by RIAGENDR 1 2 n 134944553.92 141591892.00 HI_CHOL (median [IQR]) 0.00 [0.00, 0.00] 0.00 [0.00, 0.00] race (%) 1 21381884.2 (15.8) 20251367.4 ( 14.3) 2 89315751.4 (66.2) 92486945.1 ( 65.3) 3 15045455.5 (11.1) 17967228.3 ( 12.7) 4 9201462.9 ( 6.8) 10886351.1 ( 7.7) agecat (%) (0,19] 29299546.1 (21.7) 28150760.5 ( 19.9) (19,39] 40497613.1 (30.0) 40640361.5 ( 28.7) (39,59] 41053579.4 (30.4) 42817044.0 ( 30.2) (59,Inf] 24093815.3 (17.9) 29983725.9 ( 21.2) RIAGENDR = 2 (%) 0.0 ( 0.0) 141591892.0 (100.0) Stratified by RIAGENDR p test n HI_CHOL (median [IQR]) 0.0092211 nonnorm race (%) 0.0416288 1 2 3 4 agecat (%) 0.0011757 (0,19] (19,39] (39,59] (59,Inf] RIAGENDR = 2 (%) <0.0000001 Stratified by RIAGENDR 1 2 p n 134944553.92 141591892.00 HI_CHOL (mean (SD)) 0.10 (0.30) 0.12 (0.33) 0.009 race (%) 0.042 1 21381884.189 (15.845) 20251367.389 ( 14.303) 2 89315751.415 (66.187) 92486945.142 ( 65.319) 3 15045455.461 (11.149) 17967228.319 ( 12.689) 4 9201462.858 ( 6.819) 10886351.148 ( 7.689) agecat (%) 0.001 (0,19] 29299546.109 (21.712) 28150760.544 ( 19.882) (19,39] 40497613.070 (30.011) 40640361.534 ( 28.702) (39,59] 41053579.409 (30.423) 42817044.014 ( 30.240) (59,Inf] 24093815.335 (17.855) 29983725.904 ( 21.176) RIAGENDR = 2 (%) 0.000 ( 0.000) 141591891.998 (100.000) <0.001 Stratified by RIAGENDR test n HI_CHOL (mean (SD)) race (%) 1 2 3 4 agecat (%) (0,19] (19,39] (39,59] (59,Inf] RIAGENDR = 2 (%) Stratified by RIAGENDR 1 2 n 134944553.92 141591892.00 HI_CHOL (median [IQR]) 0.00 [0.00, 0.00] 0.00 [0.00, 0.00] race (%) 1 21381884.2 (15.8) 20251367.4 ( 14.3) 2 89315751.4 (66.2) 92486945.1 ( 65.3) 3 15045455.5 (11.1) 17967228.3 ( 12.7) 4 9201462.9 ( 6.8) 10886351.1 ( 7.7) agecat (%) (0,19] 29299546.1 (21.7) 28150760.5 ( 19.9) (19,39] 40497613.1 (30.0) 40640361.5 ( 28.7) (39,59] 41053579.4 (30.4) 42817044.0 ( 30.2) (59,Inf] 24093815.3 (17.9) 29983725.9 ( 21.2) RIAGENDR = 2 (%) 0.0 ( 0.0) 141591892.0 (100.0) Stratified by RIAGENDR p test n HI_CHOL (median [IQR]) 0.0092211 nonnorm race (%) 0.0416288 1 2 3 4 agecat (%) 0.0011757 (0,19] (19,39] (39,59] (59,Inf] RIAGENDR = 2 (%) <0.0000001 ### Summary of continuous variables ### : Overall n miss p.miss mean sd median p25 p75 min max E 450 0 0 2.0 0.8 2 1 3 1 3 C 450 0 0 2.1 0.9 2 1 3 1 4 C2 450 0 0 0.5 0.5 0 0 1 0 1 ======================================================================================= ### Summary of categorical variables ### : Overall var n miss p.miss level freq percent cum.percent Y 450.0 0.3 0.1 0 272.7 60.6 60.6 1 177.0 39.4 100.0 C1 450.0 0.0 0.0 0 300.0 66.7 66.7 1 150.0 33.3 100.0 ### Summary of continuous variables ### : Overall n miss p.miss mean sd median p25 p75 min max E 450 0 0 2.0 0.8 2 1 3 1 3 C 450 0 0 2.1 0.9 2 1 3 1 4 C2 450 0 0 0.5 0.5 0 0 1 0 1 ======================================================================================= ### Summary of categorical variables ### : Overall var n miss p.miss level freq percent cum.percent Y 450.0 0.0 0.0 0 272.7 60.6 60.6 1 177.0 39.3 99.9 0.3 0.1 100.0 C1 450.0 0.0 0.0 0 300.0 66.7 66.7 1 150.0 33.3 100.0 ### Summary of continuous variables ### E: 1 n miss p.miss mean sd median p25 p75 min max E 150 0 0 1.0 0.0 1 1 1 1 1 C 150 0 0 2.1 0.9 2 1 3 1 4 C2 150 0 0 0.5 0.5 0 0 1 0 1 ------------------------------------------------------------ E: 2 n miss p.miss mean sd median p25 p75 min max E 150 0 0 2.0 0.0 2 2 2 2 2 C 150 0 0 2.1 0.9 2 1 3 1 4 C2 150 0 0 0.5 0.5 0 0 1 0 1 ------------------------------------------------------------ E: 3 n miss p.miss mean sd median p25 p75 min max E 150 0 0 3.0 0.0 3 3 3 3 3 C 150 0 0 2.1 0.9 2 1 3 1 4 C2 150 0 0 0.5 0.5 0 0 1 0 1 p-values pNormal pNonNormal E 0.0000000 0.0000000 C 0.9999992 0.9999991 C2 0.9999993 0.9999993 Standardize mean differences average 1 vs 2 1 vs 3 2 vs 3 E Inf Inf Inf Inf C 6.823456e-05 9.934218e-05 1.023522e-04 3.009264e-06 C2 6.404022e-05 9.606505e-05 7.471632e-05 2.133930e-05 ======================================================================================= ### Summary of categorical variables ### E: 1 var n miss p.miss level freq percent cum.percent Y 150.0 0.3 0.2 0 90.7 60.6 60.6 1 59.0 39.4 100.0 C1 150.0 0.0 0.0 0 100.0 66.7 66.7 1 50.0 33.3 100.0 ------------------------------------------------------------ E: 2 var n miss p.miss level freq percent cum.percent Y 150.0 0.0 0.0 0 91.0 60.7 60.7 1 59.0 39.3 100.0 C1 150.0 0.0 0.0 0 100.0 66.7 66.7 1 50.0 33.3 100.0 ------------------------------------------------------------ E: 3 var n miss p.miss level freq percent cum.percent Y 150.0 0.0 0.0 0 91.0 60.7 60.7 1 59.0 39.3 100.0 C1 150.0 0.0 0.0 0 100.0 66.7 66.7 1 50.0 33.3 100.0 p-values pApprox pExact Y 0.9998243 NA C1 0.9999998 NA Standardize mean differences average 1 vs 2 1 vs 3 2 vs 3 Y 9.949589e-04 1.492438e-03 1.488617e-03 3.821227e-06 C1 3.770972e-05 4.242269e-05 5.656458e-05 1.414189e-05 ### Summary of continuous variables ### E:C1: 1:0 n miss p.miss mean sd median p25 p75 min max E 100 0 0 1.0 0.0 1 1 1 1 1 C 100 0 0 1.6 0.5 2 1 2 1 2 C2 100 0 0 0.6 0.5 1 0 1 0 1 ------------------------------------------------------------ E:C1: 2:0 n miss p.miss mean sd median p25 p75 min max E 100 0 0 2.0 2e-16 2 2 2 2 2 C 100 0 0 1.6 5e-01 2 1 2 1 2 C2 100 0 0 0.6 5e-01 1 0 1 0 1 ------------------------------------------------------------ E:C1: 3:0 n miss p.miss mean sd median p25 p75 min max E 100 0 0 3.0 0.0 3 3 3 3 3 C 100 0 0 1.6 0.5 2 1 2 1 2 C2 100 0 0 0.6 0.5 1 0 1 0 1 ------------------------------------------------------------ E:C1: 1:1 n miss p.miss mean sd median p25 p75 min max E 50 0 0 1.0 0.0 1 1 1 1 1 C 50 0 0 3.2 0.4 3 3 3 3 4 C2 50 0 0 0.2 0.4 0 0 0 0 1 ------------------------------------------------------------ E:C1: 2:1 n miss p.miss mean sd median p25 p75 min max E 50 0 0 2.0 0.0 2 2 2 2 2 C 50 0 0 3.2 0.4 3 3 3 3 4 C2 50 0 0 0.2 0.4 0 0 0 0 1 ------------------------------------------------------------ E:C1: 3:1 n miss p.miss mean sd median p25 p75 min max E 50 0 0 3.0 0.0 3 3 3 3 3 C 50 0 0 3.2 0.4 3 3 3 3 4 C2 50 0 0 0.2 0.4 0 0 0 0 1 p-values pNormal pNonNormal E 0.000000e+00 0.00000e+00 C 2.518377e-307 0.00000e+00 C2 1.950910e-37 1.95091e-37 Standardize mean differences average 1 vs 2 1 vs 3 1 vs 4 1 vs 5 1 vs 6 E Inf 6.350292e+15 Inf 0.0000000 Inf Inf C 2.1373647 1.710913e-04 0.000146495 3.5608223 3.5673100 3.5708236 C2 0.5343248 1.710913e-04 0.000146495 0.8900053 0.8916269 0.8925051 2 vs 3 2 vs 4 2 vs 5 2 vs 6 3 vs 4 3 vs 5 E 6.350292e+15 6.350292e+15 1.4100480 6.350292e+15 Inf Inf C 2.439672e-05 3.556921e+00 3.5633882 3.566891e+00 3.5525326 3.5589756 C2 2.439672e-05 8.892636e-01 0.8908805 8.917561e-01 0.8881331 0.8897439 3 vs 6 4 vs 5 4 vs 6 5 vs 6 E 0.0000000 Inf Inf Inf C 3.5624649 0 0 0 C2 0.8906162 0 0 0 ======================================================================================= ### Summary of categorical variables ### E:C1: 1:0 var n miss p.miss level freq percent cum.percent Y 100.0 0.3 0.3 0 77.7 77.9 77.9 1 22.0 22.1 100.0 C1 100.0 0.0 0.0 0 100.0 100.0 100.0 1 0.0 0.0 100.0 ------------------------------------------------------------ E:C1: 2:0 var n miss p.miss level freq percent cum.percent Y 100.0 0.0 0.0 0 78.0 78.0 78.0 1 22.0 22.0 100.0 C1 100.0 0.0 0.0 0 100.0 100.0 100.0 1 0.0 0.0 100.0 ------------------------------------------------------------ E:C1: 3:0 var n miss p.miss level freq percent cum.percent Y 100.0 0.0 0.0 0 78.0 78.0 78.0 1 22.0 22.0 100.0 C1 100.0 0.0 0.0 0 100.0 100.0 100.0 1 0.0 0.0 100.0 ------------------------------------------------------------ E:C1: 1:1 var n miss p.miss level freq percent cum.percent Y 50.0 0.0 0.0 0 13.0 26.0 26.0 1 37.0 74.0 100.0 C1 50.0 0.0 0.0 0 0.0 0.0 0.0 1 50.0 100.0 100.0 ------------------------------------------------------------ E:C1: 2:1 var n miss p.miss level freq percent cum.percent Y 50.0 0.0 0.0 0 13.0 26.0 26.0 1 37.0 74.0 100.0 C1 50.0 0.0 0.0 0 0.0 0.0 0.0 1 50.0 100.0 100.0 ------------------------------------------------------------ E:C1: 3:1 var n miss p.miss level freq percent cum.percent Y 50.0 0.0 0.0 0 13.0 26.0 26.0 1 37.0 74.0 100.0 C1 50.0 0.0 0.0 0 0.0 0.0 0.0 1 50.0 100.0 100.0 p-values pApprox pExact Y 4.540885e-31 NA C1 4.640660e-128 NA Standardize mean differences average 1 vs 2 1 vs 3 1 vs 4 1 vs 5 1 vs 6 2 vs 3 Y 0.7311319 0.001480611 0.001486405 1.216879 1.216879 1.216879 5.793469e-06 C1 NaN 0.000000000 0.000000000 NaN NaN NaN 0.000000e+00 2 vs 4 2 vs 5 2 vs 6 3 vs 4 3 vs 5 3 vs 6 4 vs 5 4 vs 6 5 vs 6 Y 1.218891 1.218891 1.218891 1.218899 1.218899 1.218899 0 0 0 C1 NaN NaN NaN NaN NaN NaN 0 0 0 ### Summary of continuous variables ### E:C1: 1:0 n miss p.miss mean sd median p25 p75 min max E 100 0 0 1 0.0 1 1 1 1 1 C 100 0 0 2 0.5 2 1 2 1 2 ------------------------------------------------------------ E:C1: 2:0 n miss p.miss mean sd median p25 p75 min max E 100 0 0 2 2e-16 2 2 2 2 2 C 100 0 0 2 5e-01 2 1 2 1 2 ------------------------------------------------------------ E:C1: 3:0 n miss p.miss mean sd median p25 p75 min max E 100 0 0 3 0.0 3 3 3 3 3 C 100 0 0 2 0.5 2 1 2 1 2 ------------------------------------------------------------ E:C1: 1:1 n miss p.miss mean sd median p25 p75 min max E 50 0 0 1 0.0 1 1 1 1 1 C 50 0 0 3 0.4 3 3 3 3 4 ------------------------------------------------------------ E:C1: 2:1 n miss p.miss mean sd median p25 p75 min max E 50 0 0 2 0.0 2 2 2 2 2 C 50 0 0 3 0.4 3 3 3 3 4 ------------------------------------------------------------ E:C1: 3:1 n miss p.miss mean sd median p25 p75 min max E 50 0 0 3 0.0 3 3 3 3 3 C 50 0 0 3 0.4 3 3 3 3 4 p-values pNormal pNonNormal E 0.000000e+00 0 C 2.518377e-307 0 Standardize mean differences average 1 vs 2 1 vs 3 1 vs 4 1 vs 5 1 vs 6 2 vs 3 E Inf 6.350292e+15 Inf 0.000000 Inf Inf 6.350292e+15 C 2.137365 1.710913e-04 0.000146495 3.560822 3.56731 3.570824 2.439672e-05 2 vs 4 2 vs 5 2 vs 6 3 vs 4 3 vs 5 3 vs 6 4 vs 5 4 vs 6 E 6.350292e+15 1.410048 6.350292e+15 Inf Inf 0.000000 Inf Inf C 3.556921e+00 3.563388 3.566891e+00 3.552533 3.558976 3.562465 0 0 5 vs 6 E Inf C 0 ### Summary of categorical variables ### E:C1: 1:0 var n miss p.miss level freq percent cum.percent Y 100.0 0.3 0.3 0 77.7 77.9 77.9 1 22.0 22.1 100.0 C1 100.0 0.0 0.0 0 100.0 100.0 100.0 1 0.0 0.0 100.0 ------------------------------------------------------------ E:C1: 2:0 var n miss p.miss level freq percent cum.percent Y 100.0 0.0 0.0 0 78.0 78.0 78.0 1 22.0 22.0 100.0 C1 100.0 0.0 0.0 0 100.0 100.0 100.0 1 0.0 0.0 100.0 ------------------------------------------------------------ E:C1: 3:0 var n miss p.miss level freq percent cum.percent Y 100.0 0.0 0.0 0 78.0 78.0 78.0 1 22.0 22.0 100.0 C1 100.0 0.0 0.0 0 100.0 100.0 100.0 1 0.0 0.0 100.0 ------------------------------------------------------------ E:C1: 1:1 var n miss p.miss level freq percent cum.percent Y 50.0 0.0 0.0 0 13.0 26.0 26.0 1 37.0 74.0 100.0 C1 50.0 0.0 0.0 0 0.0 0.0 0.0 1 50.0 100.0 100.0 ------------------------------------------------------------ E:C1: 2:1 var n miss p.miss level freq percent cum.percent Y 50.0 0.0 0.0 0 13.0 26.0 26.0 1 37.0 74.0 100.0 C1 50.0 0.0 0.0 0 0.0 0.0 0.0 1 50.0 100.0 100.0 ------------------------------------------------------------ E:C1: 3:1 var n miss p.miss level freq percent cum.percent Y 50.0 0.0 0.0 0 13.0 26.0 26.0 1 37.0 74.0 100.0 C1 50.0 0.0 0.0 0 0.0 0.0 0.0 1 50.0 100.0 100.0 p-values pApprox pExact Y 4.540885e-31 NA C1 4.640660e-128 NA Standardize mean differences average 1 vs 2 1 vs 3 1 vs 4 1 vs 5 1 vs 6 2 vs 3 Y 0.7311319 0.001480611 0.001486405 1.216879 1.216879 1.216879 5.793469e-06 C1 NaN 0.000000000 0.000000000 NaN NaN NaN 0.000000e+00 2 vs 4 2 vs 5 2 vs 6 3 vs 4 3 vs 5 3 vs 6 4 vs 5 4 vs 6 5 vs 6 Y 1.218891 1.218891 1.218891 1.218899 1.218899 1.218899 0 0 0 C1 NaN NaN NaN NaN NaN NaN 0 0 0 Stratified by ESA 1 2 3 p test n 2.00 2.00 2.00 alive (mean (SD)) 24.50 (0.71) 39.50 (13.44) 75.00 (7.07) 0.098 ambulance = 2 (%) 50.0 50.0 50.0 1.000 == Failed tests ================================================================ -- Failure (test-modules-print.R:343:9): ModuleFormatPValues: alignes output vertically -- ModuleFormatPValues(pValues = eg_p, pDigits = 1) not equal to c("<0.1", " 0.1", " 0.1", " 0.9", " 1.0", " 1.0", " NA", " NaN"). 1/8 mismatches x[3]: " 0.2" y[3]: " 0.1" -- Failure (test-modules-print.R:447:9): ModuleConvertNormal: returns a column of numeric mean and a formatted column of character (SD) -- ModuleConvertNormal(eg_mat, digits = 0) not equal to data.frame(col1 = eg_mean, col2 = " (2140)"). Component "col2": Modes: character, numeric Component "col2": Attributes: < target is NULL, current is list > Component "col2": target is character, current is factor -- Failure (test-modules-print.R:451:9): ModuleConvertNormal: returns a column of numeric mean and a formatted column of character (SD) -- ModuleConvertNormal(eg_mat, digits = 1) not equal to data.frame(col1 = eg_mean, col2 = " (2140.4)"). Component "col2": Modes: character, numeric Component "col2": Attributes: < target is NULL, current is list > Component "col2": target is character, current is factor -- Failure (test-modules-print.R:455:9): ModuleConvertNormal: returns a column of numeric mean and a formatted column of character (SD) -- ModuleConvertNormal(eg_mat, digits = 2) not equal to data.frame(col1 = eg_mean, col2 = " (2140.39)"). Component "col2": Modes: character, numeric Component "col2": Attributes: < target is NULL, current is list > Component "col2": target is character, current is factor -- Failure (test-modules-print.R:459:9): ModuleConvertNormal: returns a column of numeric mean and a formatted column of character (SD) -- ModuleConvertNormal(eg_mat, digits = 3) not equal to data.frame(col1 = eg_mean, col2 = " (2140.389)"). Component "col2": Modes: character, numeric Component "col2": Attributes: < target is NULL, current is list > Component "col2": target is character, current is factor -- Failure (test-modules-print.R:466:9): ModuleConvertNormal: respects formatOptions -- ModuleConvertNormal(...) not equal to data.frame(col1 = eg_mean, col2 = " (2,140)"). Component "col2": Modes: character, numeric Component "col2": Attributes: < target is NULL, current is list > Component "col2": target is character, current is factor -- Failure (test-modules-print.R:471:9): ModuleConvertNormal: respects formatOptions -- ModuleConvertNormal(...) not equal to data.frame(col1 = eg_mean, col2 = " (2,140D4)"). Component "col2": Modes: character, numeric Component "col2": Attributes: < target is NULL, current is list > Component "col2": target is character, current is factor -- Failure (test-modules-print.R:476:9): ModuleConvertNormal: respects formatOptions -- ModuleConvertNormal(...) not equal to data.frame(col1 = eg_mean, col2 = " (2,140D39)"). Component "col2": Modes: character, numeric Component "col2": Attributes: < target is NULL, current is list > Component "col2": target is character, current is factor -- Failure (test-modules-print.R:481:9): ModuleConvertNormal: respects formatOptions -- ModuleConvertNormal(...) not equal to data.frame(col1 = eg_mean, col2 = " (2,140D389)"). Component "col2": Modes: character, numeric Component "col2": Attributes: < target is NULL, current is list > Component "col2": target is character, current is factor -- Failure (test-modules-print.R:519:9): ModuleConvertNonNormal: returns a column of numeric mean and a formatted column of character (SD) -- ModuleConvertNonNormal(eg_mat, digits = 0) not equal to data.frame(col1 = eg_median, col2 = " [872, 1980]"). Component "col2": Modes: character, numeric Component "col2": Attributes: < target is NULL, current is list > Component "col2": target is character, current is factor -- Failure (test-modules-print.R:523:9): ModuleConvertNonNormal: returns a column of numeric mean and a formatted column of character (SD) -- ModuleConvertNonNormal(eg_mat, digits = 1) not equal to data.frame(col1 = eg_median, col2 = " [871.5, 1980.0]"). Component "col2": Modes: character, numeric Component "col2": Attributes: < target is NULL, current is list > Component "col2": target is character, current is factor -- Failure (test-modules-print.R:527:9): ModuleConvertNonNormal: returns a column of numeric mean and a formatted column of character (SD) -- ModuleConvertNonNormal(eg_mat, digits = 2) not equal to data.frame(col1 = eg_median, col2 = " [871.50, 1980.00]"). Component "col2": Modes: character, numeric Component "col2": Attributes: < target is NULL, current is list > Component "col2": target is character, current is factor -- Failure (test-modules-print.R:531:9): ModuleConvertNonNormal: returns a column of numeric mean and a formatted column of character (SD) -- ModuleConvertNonNormal(eg_mat, digits = 3) not equal to data.frame(col1 = eg_median, col2 = " [871.500, 1980.000]"). Component "col2": Modes: character, numeric Component "col2": Attributes: < target is NULL, current is list > Component "col2": target is character, current is factor -- Failure (test-modules-print.R:538:9): ModuleConvertNonNormal: respects formatOptions -- ModuleConvertNonNormal(...) not equal to data.frame(col1 = eg_median, col2 = " [872, 1,980]"). Component "col2": Modes: character, numeric Component "col2": Attributes: < target is NULL, current is list > Component "col2": target is character, current is factor -- Failure (test-modules-print.R:543:9): ModuleConvertNonNormal: respects formatOptions -- ModuleConvertNonNormal(...) not equal to data.frame(col1 = eg_median, col2 = " [871D5, 1,980D0]"). Component "col2": Modes: character, numeric Component "col2": Attributes: < target is NULL, current is list > Component "col2": target is character, current is factor -- Failure (test-modules-print.R:548:9): ModuleConvertNonNormal: respects formatOptions -- ModuleConvertNonNormal(...) not equal to data.frame(col1 = eg_median, col2 = " [871D50, 1,980D00]"). Component "col2": Modes: character, numeric Component "col2": Attributes: < target is NULL, current is list > Component "col2": target is character, current is factor -- Failure (test-modules-print.R:553:9): ModuleConvertNonNormal: respects formatOptions -- ModuleConvertNonNormal(...) not equal to data.frame(col1 = eg_median, col2 = " [871D500, 1,980D000]"). Component "col2": Modes: character, numeric Component "col2": Attributes: < target is NULL, current is list > Component "col2": target is character, current is factor [ FAIL 17 | WARN 135 | SKIP 0 | PASS 542 ] Error: Test failures Execution halted * checking for unstated dependencies in vignettes ... OK * checking package vignettes in 'inst/doc' ... OK * checking re-building of vignette outputs ... [13s] OK * checking PDF version of manual ... OK * DONE Status: 1 ERROR