POINT: Protein Structure Guided Local Test
Provides an implementation of a rare variant association test that utilizes protein tertiary structure to increase signal and to identify likely causal variants. Performs structure-guided collapsing, which leads to local tests that borrow information from neighboring variants on a protein and that provide association information on a variant-specific level. For details of the implemented method see West, R. M., Lu, W., Rotroff, D. M., Kuenemann, M., Chang, S-M., Wagner M. J., Buse, J. B., Motsinger-Reif, A., Fourches, D., and Tzeng, J-Y. (2019) <doi:10.1371/journal.pcbi.1006722>.
| Version: |
1.2 |
| Depends: |
methods, stats, rARPACK, Matrix, CompQuadForm |
| Published: |
2022-06-06 |
| Author: |
Rachel Marceau West, Shannon T. Holloway |
| Maintainer: |
Shannon T. Holloway <shannon.t.holloway at gmail.com> |
| License: |
GPL-2 |
| NeedsCompilation: |
no |
| CRAN checks: |
POINT results |
Documentation:
Downloads:
Linking:
Please use the canonical form
https://CRAN.R-project.org/package=POINT
to link to this page.