SmoothHazard: Estimation of Smooth Hazard Models for Interval-Censored Data
with Applications to Survival and Illness-Death Models
Estimation of two-state (survival) models and irreversible illness-
death models with possibly interval-censored,left-truncated and right-censored
data. Proportional intensities regression models can be specified to allow for
covariates effects separately for each transition. We use either a parametric
approach with Weibull baseline intensities or a semi-parametric approach with
M-splines approximation of baseline intensities in order to obtain smooth
estimates of the hazard functions. Parameter estimates are obtained by maximum
likelihood in the parametric approach and by penalized maximum likelihood in the
semi-parametric approach.
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