crispRdesignR: Guide Sequence Design for CRISPR/Cas9
Designs guide sequences for CRISPR/Cas9 genome editing and
provides information on sequence features pertinent to guide
efficiency. Sequence features include annotated off-target
predictions in a user-selected genome and a predicted efficiency
score based on the model described in Doench et al. (2016)
<doi:10.1038/nbt.3437>. Users are able to import additional genomes
and genome annotation files to use when searching and annotating
off-target hits. All guide sequences and off-target data can be
generated through the 'R' console with sgRNA_Design() or through
'crispRdesignR's' user interface with crispRdesignRUI(). CRISPR
(Clustered Regularly Interspaced Short Palindromic Repeats) and the
associated protein Cas9 refer to a technique used in genome editing.
| Version: |
1.1.6 |
| Depends: |
R (≥ 2.10) |
| Imports: |
Biostrings, gbm, GenomicRanges, BiocGenerics, IRanges, GenomeInfoDb, S4Vectors, rtracklayer, stringr, vtreat, shiny, DT |
| Suggests: |
BSgenome.Scerevisiae.UCSC.sacCer2 |
| Published: |
2021-01-11 |
| Author: |
Dylan Beeber [aut, cre],
Frederic Chain [aut] |
| Maintainer: |
Dylan Beeber <dylan.beeber at gmail.com> |
| License: |
GPL-3 |
| URL: |
<https://github.com/dylanbeeber/crispRdesignR> |
| NeedsCompilation: |
no |
| Materials: |
README |
| CRAN checks: |
crispRdesignR results |
Documentation:
Downloads:
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